Immunoglobulin domain

Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

Immunoglobulin domain
Immunoglobulin domain
	Structure of an antigen binding fragment of an antibody.
Identifiers
Symbol	ig
Pfam	PF00047
Pfam clan	CL0159
InterPro	IPR013151
PROSITE	PDOC00262
SCOP2	8fab / SCOPe / SUPFAM
OPM superfamily	193
OPM protein	5f71
CDD	cd00096
Membranome	2
Pfam
Available protein structures:
Pfam	structures / ECOD
PDB	RCSB PDB; PDBe; PDBj
PDBsum	structure summary

The immunoglobulin domain, also known as the immunoglobulin fold, is a type of protein domain that consists of a 2-layer sandwich of 7-9 antiparallel β-strands arranged in two β-sheets with a Greek key topology,^[1]^[2] consisting of about 125 amino acids.

The backbone switches repeatedly between the two β-sheets. Typically, the pattern is (N-terminal β-hairpin in sheet 1)-(β-hairpin in sheet 2)-(β-strand in sheet 1)-(C-terminal β-hairpin in sheet 2). The cross-overs between sheets form an "X", so that the N- and C-terminal hairpins are facing each other.

Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin, and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein–protein and protein–ligand interactions.^[3]

Examples

Human genes encoding proteins containing the immunoglobulin domain include:

References

^ Bork P, Holm L, Sander C (September 1994). "The immunoglobulin fold. Structural classification, sequence patterns and common core". J. Mol. Biol. 242 (4): 309–20. doi:10.1006/jmbi.1994.1582. PMID 7932691.
^ Brümmendorf T, Rathjen FG (1995). "Cell adhesion molecules 1: immunoglobulin superfamily". Protein Profile. 2 (9): 963–1108. PMID 8574878.
^ Williams AF, Barclay AN (1988). "The immunoglobulin superfamily—domains for cell surface recognition". Annu. Rev. Immunol. 6: 381–405. doi:10.1146/annurev.iy.06.040188.002121. PMID 3289571.

External links

SCOP listing of immunoglobulin domains of known structure

This article incorporates text from the public domain Pfam and InterPro: IPR013151

[pmid7932691-1] Bork P, Holm L, Sander C (September 1994). "The immunoglobulin fold. Structural classification, sequence patterns and common core". J. Mol. Biol. 242 (4): 309–20. doi:10.1006/jmbi.1994.1582. PMID 7932691.

[pmid8574878-2] Brümmendorf T, Rathjen FG (1995). "Cell adhesion molecules 1: immunoglobulin superfamily". Protein Profile. 2 (9): 963–1108. PMID 8574878.

[pmid3289571-3] Williams AF, Barclay AN (1988). "The immunoglobulin superfamily—domains for cell surface recognition". Annu. Rev. Immunol. 6: 381–405. doi:10.1146/annurev.iy.06.040188.002121. PMID 3289571.

[1]

[2]

[3]

v t e Protein tertiary structure
General	Structural domain Protein folding Structure determination methods
All-α folds:	Helix bundle Globin fold Homeodomain fold Alpha solenoid Death fold
All-β folds:	Immunoglobulin domain Beta barrel Beta-propeller Beta helix
α/β folds:	TIM barrel Leucine-rich repeat Flavodoxin fold Rossmann fold Thioredoxin fold Trefoil knot fold
α+β folds:	DNA clamp Ferredoxin fold Ribonuclease A SH2-like fold
Irregular folds:	Conotoxin

Examples

See also

References

External links