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Igor Meglinski

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Igor Meglinski
Igor Meglinski in April 2015
BornApril 3, 1968 (1968-04-03) (age 56)
USSR
CitizenshipUnited Kingdom
Alma mater
Known for
Awards
Scientific career
FieldsMedical optical imaging, Diffusing-wave spectroscopy, Dynamic light scattering, Monte Carlo method for photon transport, Coherent backscattering, Orbital angular momentum of light, Optical vortex
InstitutionsAston University
Doctoral advisorsBritton Chance and Valery Tuchin
Other academic advisorsArjun Yodh

Igor Meglinski is a British, New Zealand and Finnish scientist serving as a principal investigator at the College of Engineering & Physical Sciences at Aston University, where he is a Professor in Quantum Biophotonics and Biomedical Engineering. He is a Faculty member in the School of Engineering and Technology at the Department of Mechanical, Biomedical & Design Engineering, and is also associated with the Aston Institute of Photonic Technologies (AIPT) and Aston Research Centre for Health in Ageing (ARCHA).

Background and Education

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Meglinski obtained his BSc/MSc in Laser Physics from Saratov State University. In 1994, he became the first inaugural recipient of the 'Presidential Boris Yeltsin Award,' the most prestigious award for young scientists in the Russian Federation, supporting overseas study. This accolade facilitated his pursuit of a PhD degree in 1997, which he completed at the interface between Saratov State University and the University of Pennsylvania under the supervision of Professor Britton Chance, Professor Arjun Yodh, and Professor Valery V. Tuchin. His master's research involved the development of one of the earliest versions of the Monte Carlo method for simulating the propagation of laser radiation in tissue-like highly scattering environment, including the consideration of 3D macroinhomogeneities.[1] In the PhD studies he contributed to the invention and early development of Diffusing-wave spectroscopy (DWS) and its pioneering application for non-invasive monitoring of blood flow and superficial blood microcirculation in vivo.[2]

Research

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After a few years of postdoctoral research at the School of Physics at the University of Exeter, Igor Meglinski joined Cranfield University in 2001 as a Lecturer and Director of the Biomedical Optical Diagnostics Laboratory within the School of Engineering. In 2007, he became the Head of Bio-Photonics & Bio-Medical Optical Diagnostics in the School of Health at Cranfield University. His research has primarily focused on a quantitative assessment of transdermal penetration of pharmaceutical and skin care product, and skin tissues chromophores and pigmentation by optical and near-infrared spectroscopy (NIR). He developed computational model of human skin for reflected spectra simulation,.[3][4] He also made significant contributions to the development of Optical Coherence Tomography (OCT), particularly in its application for skin and skin tissue diagnosis.[5] Additionally, he has conducted studies applying the Monte Carlo method for simulating coherent effects in multiple scattering.[6] He was involved in the invention of an optical method designed for analysis and monitoring.[7] This method can be applied to detect and monitor various changes in physico-chemical parameters, concentrations of analytes, and chemical and biological processes.[8]

Since 2009, while at the University of Otago (New Zealand), Prof. Meglinski's research has expanded to include the development of a medical device combining multispectral optoacoustic tomography and ultrasound-modulated optical tomography.[9] This innovative device is designed to provide clear, accurate images of tissue, with the ultimate goal of enabling cancer cell analysis at much earlier stages than currently possible with existing technology, and at a significantly reduced cost. As a Node leader in the World Consortium Biophotonics4Life (BP4L), representing New Zealand on the global stage of biophotonics-based research, Prof. Meglinski actively engages in the exploration of the fundamental properties of light and ultrasound in cancer diagnostics, collaborating with clinicians at the University of Otago Dunedin School of Medicine,[10][11] and with leading international scientists,[12] while also being involved in the investigation of brain activity.[13] He pioneered the application of circularly polarized light to distinguish between successive grades of cancer.[14] This work demonstrated that the phase shift of polarized light backscattered from biological tissue samples carries important information about the presence of cervical intraepithelial neoplasia. In addition, in collaboration with his colleague, he developed a cloud-based online computational toolbox for the Biophotonics and Biomedical Optics scientific community,.[15][16] Nowadays, this toolbox is hosted at www.biophotonics.fi and is used extensively by a global audience of over 7500 users, including PhD students and young researchers.

In 2014, Meglinski returned back to Europe, heading the Department of Opto-Electronic and Measurement Techniques at the Faculty of Information Technology and Electrical Engineering (ITEE) at the University of Oulu in Finland. Utilizing advanced photonics-based technologies, emerging paradigms in machine learning, and new concepts in computational modeling of light-tissue interaction, Prof. Meglinski and his team at the University of Oulu developed 'Polarization Sensitive Optical Biopsy'.[17] This technique facilitates advanced diagnosis in cell cultures and screening of tissue samples, incorporating definitive pathology methods.Additionally, Prof. Meglinski and his team developed an Optical Tweezers (OT) based technology to investigate the impact of various nanoparticles on the mutual interaction of red blood cells.[18][19] This research demonstrates the potential of OT in studying targeted drug delivery systems, providing crucial insights into how nanoparticles can influence red blood cell behavior — a key factor in the development of effective and efficient drug delivery carriers.[20]

Since 2019 he is Professor in Quantum Biophotonics & Biomedical Engineering in Aston University, working at the interface between College of Engineering & Physical Sciences and College of Life & Health Sciences. His research focuses on quantum biophotonics and biomedical engineering, where he has pioneered the application of Orbital angular momentum of light (OAM) for the quantification of exosomes and the exploration of intracellular communication.[21] Continuing his research and development of Dynamic light scattering based imaging of blood flow,[22] he is exploring hemodynamic patterns in postmortem mice brains.[23] In addition, he discovered more accurate way of checking blood flow in the feet of type 2 diabetes patients,[24][25][26] and pioneered using art to bridge the gap between complex scientific findings and the public.[27][28]

Publications

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Professor Meglinski is author and co-author of over 450 scientific publications.[29] His h-index is 51.[30]

Honours, awards and professional recognition

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References

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  1. ^ Meglinski, Igor (1992). "Calculation of radiation intensity within biotissue with macroinhomogeneities using a Monte Carlo method". Proc SPIE. 1981: 234–239. doi:10.1117/12.146473.
  2. ^ Meglinski, Igor; Boas, David; Yodh, Arjun; Chance, Britton (1996). "In vivo Measuring of Blood Flow Changes using Diffusing Wave Correlation Techniques". OSA Trends in Optics and Photonics Series. 3: CM2. doi:10.1364/BOSD.1996.CM2. ISBN 1-55752-427-0.
  3. ^ Meglinski, Igor; Matcher, Stephen (2002). "Quantitative assessment of skin layers absorption and skin reflectance spectra simulation in the visible and near-infrared spectral regions". Physiological Measurement. 23 (4): 741–753. doi:10.1088/0967-3334/23/4/312. hdl:1826/885. PMID 12450273.
  4. ^ Meglinski, Igor; Matcher, Stephen (2003). "Computer simulation of the skin reflectance spectra". Computer Methods and Programs in Biomedicine. 70 (2): 179–186. doi:10.1016/S0169-2607(02)00099-8. hdl:1826/884. PMID 12507793.
  5. ^ Proscurin, Sergei; Meglinski, Igor (2007). "Optical coherence tomography imaging depth enhancement by superficial skin optical clearing". Laser Physics Letters. 4 (11): 824–826. Bibcode:2007LaPhL...4..824P. doi:10.1002/lapl.200710056. S2CID 119375085.
  6. ^ Meglinski, Igor; Kuzmin, Vladimir; Churmakov, Dmitry; Greenhalgh, Douglas (2005). "Monte Carlo simulation of coherent effects in multiple scattering". Proceedings of the Royal Society A. 461 (2053): 43–53. Bibcode:2005RSPSA.461...43M. doi:10.1098/rspa.2004.1369. hdl:1826/896. S2CID 53600398.
  7. ^ US 20100304421, S.A. Piletsky, I. Meglinski, E. Moczko, "OPTICAL MONITORING METHOD", published 2010-12-02, field 2008-11-06
  8. ^ Moczko, Ewa; Meglinski, Igor; Bessant, Conrad; Piletsky, Sergey (2009). "Dyes Assay for Measuring Physicochemical Parameters". Analytical Chemistry. 81 (6): 2311–2316. doi:10.1021/ac802482h. PMID 19220044.
  9. ^ An excerpt from He Kitenga Horizons, a University of Otago publication (December 2013)
  10. ^ Centre for Translational Cancer Research
  11. ^ Grant allows cancer research
  12. ^ Dr Chen, of the University of Central Oklahoma, in the United States
  13. ^ Biophotonics potential, University of Otago MAGAZINE, February 2010, page 31
  14. ^ Kunnen, Britt; Macdonald, Callum; Doronin, Alexander; Jacques, Steven; Meglinski, Igor (2015). "Application of circularly polarized light for non-invasive diagnosis of cancerous tissues and turbid tissue-like scattering media". Journal of Biophotonics. 8 (4): 317–323. doi:10.1002/jbio.201400104. PMID 25328034.
  15. ^ Doronin, Alexander; Meglinski, Igor (2011). "Online Monte Carlo for biomedical optics". SPIE Newsroom. doi:10.1117/2.1201110.003879.
  16. ^ Doronin, Alexander; Meglinski, Igor (2011). "Online object oriented Monte Carlo computational tool for the needs of biomedical optics". Biomedical Optics Express. 2 (9): 2461–2469. doi:10.1364/BOE.2.002461. PMC 3184856. PMID 21991540.
  17. ^ Finnish Biobanks and Biomedical Research News: Polarization Sensitive Optical Biopsy with Diffusely Reflected Light
  18. ^ Researchers experiment with tools to 'maneuver' medicine-carrying red blood cells, Science X, Phys.org
  19. ^ Avsievich, Tatiana; Popov, Alexey; Bykov, Alexander; Meglinski, Igor (2019). "Mutual interaction of red blood cells influenced by nanoparticles". Scientific Reports. 9 (1): 5147. Bibcode:2019NatSR...9.5147A. doi:10.1038/s41598-019-41643-x. PMC 6435805. PMID 30914741.
  20. ^ Zhu, Ruixue; Avsievich, Tatiana; Popov, Alexey; Bykov, Alexander; Meglinski, Igor (2021). "In vivo nano-biosensing element of red blood cell-mediated delivery". Biosensors & Bioelectronics. 175: 112845. doi:10.1016/j.bios.2020.112845. PMID 33262059.
  21. ^ Orbital Angular Momentum of Light for Exosomes Quantification and Intracellular Communication, Interdisciplinary APEX Awards (2021)
  22. ^ Sdobnov, Anton; Piavchenko, Gennadii; Bykov, Alexander; Meglinski, Igor (2024). "Advances in Dynamic Light Scattering Imaging of Blood Flow". Lasers & Photonics Reviews. 18 (12): e202100216. doi:10.1002/jbio.202100216. PMID 34534405.
  23. ^ Piavchenko, Gennadii; Kozlov, Igor; Dremin, Victor; Meglinski, Igor (2021). "Impairments of cerebral blood flow microcirculation in rats brought on by cardiac cessation and respiratory arrest". Journal of Biophotonics. 14 (12): e202100216. doi:10.1002/jbio.202100216. PMID 34534405.
  24. ^ "Laser Method Boosts Accuracy of Blood Flow Measurements in Feet", PHOTONICS Spectra (February 2023)
  25. ^ Aston University scientists discover more accurate way of checking blood flow in the feet of type 2 diabetes patients
  26. ^ Aston devises more accurate method to check blood flow in diabetes patients
  27. ^ Aston University researcher uses art to help demystify complex science
  28. ^ Aston University researcher uses art to help demystify complex science
  29. ^ Igor Meglinski Research Gate
  30. ^ "Google Scholar: Igor Meglinski".
  31. ^ EurekAlert! American Association for the Advancement of Science (AAAS): Top 100 in Photonics
  32. ^ Igor Meglinski Top 100 in Photonics
  33. ^ Igor Meglinski Photonics Top 100 in life sciences, biophotonics, and biomedical optics
  34. ^ Aston University professor elected Fellow of Royal Microscopical Society
  35. ^ The Optical Society Elected Fellows
  36. ^ The Royal Society APEX Award
  37. ^ Complete List of SPIE Fellows
  38. ^ Fellows of Institute of Physics
  39. ^ Senior Member of IEEE
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