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Integrin alpha 6

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ITGA6
Identifiers
AliasesITGA6, CD49f, ITGA6B, VLA-6, integrin subunit alpha 6, JEB6
External IDsOMIM: 147556; MGI: 96605; HomoloGene: 20091; GeneCards: ITGA6; OMA:ITGA6 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001277970
NM_008397

RefSeq (protein)

NP_000201
NP_001073286
NP_001303235
NP_001352458
NP_001352459

NP_001264899
NP_032423
NP_001393187

Location (UCSC)Chr 2: 172.43 – 172.51 MbChr 2: 71.58 – 71.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

Function

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The ITGA6 protein product is the integrin alpha chain alpha 6. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, alpha 6 may combine with beta 4 in the integrin referred to as TSP180, or with beta 1 in the integrin VLA-6. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. Two transcript variants encoding different isoforms have been found for this gene.[5] Specific loss of this integrin chain in the intestinal epithelium, and thus of their hemidesmosomes, induces long-standing colitis and infiltrating adenocarcinomas.[6]

Interactions

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ITGA6 has been shown to interact with TSPAN4[7] and GIPC1.[8]

See also

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References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000091409Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027111Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: ITGA6 integrin, alpha 6".
  6. ^ De Arcangelis A, Hamade H, Alpy F, Normand S, Bruyère E, Lefebvre O, et al. (October 2017). "Hemidesmosome integrity protects the colon against colitis and colorectal cancer". Gut. 66 (10): 1748–1760. doi:10.1136/gutjnl-2015-310847. PMC 5595104. PMID 27371534.
  7. ^ Tachibana I, Bodorova J, Berditchevski F, Zutter MM, Hemler ME (November 1997). "NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins". The Journal of Biological Chemistry. 272 (46): 29181–9. doi:10.1074/jbc.272.46.29181. PMID 9360996.
  8. ^ Tani TT, Mercurio AM (September 2001). "PDZ interaction sites in integrin alpha subunits. T14853, TIP/GIPC binds to a type I recognition sequence in alpha 6A/alpha 5 and a novel sequence in alpha 6B". The Journal of Biological Chemistry. 276 (39): 36535–42. doi:10.1074/jbc.M105785200. PMID 11479315.

Further reading

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  • Lipscomb EA, Mercurio AM (September 2005). "Mobilization and activation of a signaling competent alpha6beta4integrin underlies its contribution to carcinoma progression". Cancer and Metastasis Reviews. 24 (3): 413–23. doi:10.1007/s10555-005-5133-4. PMID 16258729. S2CID 26150860.
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