ISCA1

ISCA1
Identifiers
Aliases	ISCA1, HBLD2, ISA1, hIscA, iron-sulfur cluster assembly 1, MMDS5
External IDs	OMIM: 611006; MGI: 1916296; HomoloGene: 87862; GeneCards: ISCA1; OMA:ISCA1 - orthologs
Gene location (Human)
Chr.	Chromosome 9 (human)
End	86,283,102 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	59,917,624 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; biceps brachii; ; Skeletal muscle tissue of biceps brachii; ; right ventricle; ; trabecular bone; ; kidney tubule; ; Epithelium of choroid plexus; ; pons; ; myocardium; ; Brodmann area 23;
	Top expressed in
	bone marrow; ; brown adipose tissue; ; tibialis anterior muscle; ; soleus muscle; ; quadriceps femoris muscle; ; masseter muscle; ; extraocular muscle; ; myocardium of ventricle; ; muscle of thigh; ; cardiac muscles;
	More reference expression data
	n/a
Gene ontology
Molecular function	iron-sulfur cluster binding; ferrous iron binding; structural molecule activity; metal ion binding; 2 iron, 2 sulfur cluster binding;
Cellular component	mitochondrion; mitochondrial matrix;
Biological process	iron-sulfur cluster assembly; protein maturation by iron-sulfur cluster transfer; small molecule metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	81689
	69046
	ENSG00000135070
	ENSMUSG00000044792
	Q9BUE6
	Q9D924
	NM_030940
	NM_026921
	NP_112202
	NP_081197
	Wikidata
View/Edit Human	View/Edit Mouse

Iron-sulfur cluster assembly 1 homolog, mitochondrial is an evolutionarily highly conserved protein for the biogenesis of iron-sulfur cluster across species.^[5] In humans it is encoded by the ISCA1 gene.^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000135070 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000044792 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Beilschmidt LK, Puccio HM (May 2014). "Mammalian Fe-S cluster biogenesis and its implication in disease". Biochimie. 100: 48–60. doi:10.1016/j.biochi.2014.01.009. PMID 24440636.
^ Cózar-Castellano I, del Valle Machargo M, Trujillo E, Arteaga MF, González T, Martín-Vasallo P, Avila J (Aug 2004). "hIscA: a protein implicated in the biogenesis of iron-sulfur clusters". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1700 (2): 179–88. doi:10.1016/j.bbapap.2004.05.004. PMID 15262227.
^ "Entrez Gene: ISCA1 iron-sulfur cluster assembly 1 homolog (S. cerevisiae)".

Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (Apr 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000135070 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000044792 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Beil14-5] Beilschmidt LK, Puccio HM (May 2014). "Mammalian Fe-S cluster biogenesis and its implication in disease". Biochimie. 100: 48–60. doi:10.1016/j.biochi.2014.01.009. PMID 24440636.

[pmid15262227-6] Cózar-Castellano I, del Valle Machargo M, Trujillo E, Arteaga MF, González T, Martín-Vasallo P, Avila J (Aug 2004). "hIscA: a protein implicated in the biogenesis of iron-sulfur clusters". Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics. 1700 (2): 179–88. doi:10.1016/j.bbapap.2004.05.004. PMID 15262227.

[entrez-7] "Entrez Gene: ISCA1 iron-sulfur cluster assembly 1 homolog (S. cerevisiae)".

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References

Further reading