INPP5A

INPP5A
Identifiers
Aliases	INPP5A, 5PTASE, inositol polyphosphate-5-phosphatase A
External IDs	OMIM: 600106; MGI: 2686961; HomoloGene: 4045; GeneCards: INPP5A; OMA:INPP5A - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	132,783,480 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	139,159,568 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; saphenous vein; ; myocardium of left ventricle; ; middle temporal gyrus; ; popliteal artery; ; tibial arteries; ; sperm; ; external globus pallidus; ; right ventricle; ; gastric mucosa;
	Top expressed in
	Ileal epithelium; ; cardiac muscle tissue of left ventricle; ; lobe of cerebellum; ; right ventricle; ; cerebellar vermis; ; interventricular septum; ; plantaris muscle; ; ascending aorta; ; extensor digitorum longus muscle; ; soleus muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	PH domain binding; inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity; protein binding; hydrolase activity; inositol-1,4,5-trisphosphate 5-phosphatase activity; inositol-polyphosphate 5-phosphatase activity;
Cellular component	plasma membrane; membrane; intracellular anatomical structure;
Biological process	inositol phosphate metabolic process; phosphatidylinositol dephosphorylation; inositol phosphate-mediated signaling; inositol phosphate dephosphorylation; dephosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	3632
	212111
	ENSG00000068383
	ENSMUSG00000025477
	Q14642; Q5T1B3
	Q7TNC9
	NM_005539; NM_001321042
	NM_001127363; NM_183144; NM_001355162
	NP_001307971; NP_005530
	NP_001120835; NP_001342091; NP_898967
	Wikidata
View/Edit Human	View/Edit Mouse

Type I inositol-1,4,5-trisphosphate 5-phosphatase is an enzyme that in humans is encoded by the INPP5A gene.^[5]^[6]

The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000068383 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025477 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ De Smedt F, Verjans B, Mailleux P, Erneux C (Jul 1994). "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells". FEBS Lett. 347 (1): 69–72. doi:10.1016/0014-5793(94)00509-5. PMID 8013665. S2CID 4936881.
^ ^a ^b "Entrez Gene: INPP5A inositol polyphosphate-5-phosphatase, 40kDa".

Laxminarayan KM, Chan BK, Tetaz T, et al. (1994). "Characterization of a cDNA encoding the 43-kDa membrane-associated inositol-polyphosphate 5-phosphatase". J. Biol. Chem. 269 (25): 17305–10. doi:10.1016/S0021-9258(17)32555-3. PMID 8006039.
Mitchell CA, Speed CJ, Nicholl J, Sutherland GR (1996). "Chromosomal mapping of the gene (INPP5A) encoding the 43-kDa membrane-associated inositol polyphosphate 5-phosphatase to 10q26.3 by fluorescence in situ hybridization". Genomics. 31 (1): 139–40. doi:10.1006/geno.1996.0023. PMID 8808294.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Auethavekiat V, Abrams CS, Majerus PW (1997). "Phosphorylation of platelet pleckstrin activates inositol polyphosphate 5-phosphatase I." J. Biol. Chem. 272 (3): 1786–90. doi:10.1074/jbc.272.3.1786. PMID 8999861.
Campbell JK, Gurung R, Romero S, et al. (1998). "Activation of the 43 kDa inositol polyphosphate 5-phosphatase by 14-3-3zeta". Biochemistry. 36 (49): 15363–70. doi:10.1021/bi9708085. PMID 9398266.
Lee SH, Davison JA, Vidal SM, Belouchi A (2001). "Cloning, expression and chromosomal location of NKX6B TO 10Q26, a region frequently deleted in brain tumors". Mamm. Genome. 12 (2): 157–62. doi:10.1007/s003350010247. PMID 11210186. S2CID 22368753.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hartmann TB, Thiel D, Dummer R, et al. (2004). "SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma". Br. J. Dermatol. 150 (2): 252–8. doi:10.1111/j.1365-2133.2004.05651.x. PMID 14996095. S2CID 42495130.
Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 10 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000068383 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025477 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8013665-5] De Smedt F, Verjans B, Mailleux P, Erneux C (Jul 1994). "Cloning and expression of human brain type I inositol 1,4,5-trisphosphate 5-phosphatase. High levels of mRNA in cerebellar Purkinje cells". FEBS Lett. 347 (1): 69–72. doi:10.1016/0014-5793(94)00509-5. PMID 8013665. S2CID 4936881.

[entrez-6] "Entrez Gene: INPP5A inositol polyphosphate-5-phosphatase, 40kDa".

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References

Further reading