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IHPK2

From Wikipedia, the free encyclopedia
IP6K2
Identifiers
AliasesIP6K2, IHPK2, PIUS, inositol hexakisphosphate kinase 2, InsP6K2
External IDsOMIM: 606992; MGI: 1923750; HomoloGene: 56929; GeneCards: IP6K2; OMA:IP6K2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_029634

RefSeq (protein)

NP_083910
NP_001366529
NP_001366530
NP_001366531
NP_001366532

Location (UCSC)Chr 3: 48.69 – 48.74 Mbn/a
PubMed search[2][3]
Wikidata
View/Edit HumanView/Edit Mouse

Inositol hexakisphosphate kinase 2 is an enzyme that in humans is encoded by the IP6K2 gene.[4][5]

This gene encodes a protein that belongs to the inositol phosphokinase (IPK) family. This protein is likely responsible for the conversion of inositol hexakisphosphate (InsP6) to diphosphoinositol pentakisphosphate (InsP7/PP-InsP5). It may also convert 1,3,4,5,6-pentakisphosphate (InsP5) to PP-InsP4 and affect the growth suppressive and apoptotic activities of interferon-beta in some ovarian cancers. Alternative splicing results in multiple transcript variants encoding different isoforms.[5]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000068745Ensembl, May 2017
  2. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ Saiardi A, Erdjument-Bromage H, Snowman AM, Tempst P, Snyder SH (May 2000). "Synthesis of diphosphoinositol pentakisphosphate by a newly identified family of higher inositol polyphosphate kinases". Curr Biol. 9 (22): 1323–6. doi:10.1016/S0960-9822(00)80055-X. PMID 10574768. S2CID 15311443.
  5. ^ a b "Entrez Gene: IHPK2 inositol hexaphosphate kinase 2".

Further reading

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See also

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