Histone cluster 2 h3 family member d

H3C13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2IIJ, 2X4W, 2X4X, 2X4Y, 3AV1, 3DB3, 3MO8, 3R93, 4MZF, 4MZG, 4MZH, 4OUC, 5BO0, 2HIO, 5B0Z, 2ARO, 1EQZ, 1HQ3, 4KGC, 1TZY, 4UUZ, 2F8N, 5B0Y, 4LD9, 5B40, 5CIU
Identifiers
Aliases	H3C13, histone cluster 2 H3 family member d, H3 clustered histone 13, HIST2H3D, H3C15, H3C14
External IDs	MGI: 2448320; HomoloGene: 134489; GeneCards: H3C13; OMA:H3C13 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	149,813,693 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	23,929,585 bp
RNA expression pattern
	Top expressed in
	bone marrow cells; ; testicle; ; Achilles tendon; ; blood; ; right ovary; ; granulocyte; ; left ovary; ; fundus; ; corpus callosum; ; right adrenal cortex;
	Top expressed in
	uterus; ; embryo; ; ventricular zone; ; spermatid; ; embryo; ; spermatocyte; ; bone marrow; ; Mesencephalon; ; yolk sac; ; tail of embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein heterodimerization activity; DNA binding; histone binding; protein binding; chromatin binding; nucleosomal DNA binding;
Cellular component	extracellular exosome; extracellular region; nucleoplasm; chromosome; nucleosome; nucleus; chromatin;
Biological process	epigenetic maintenance of chromatin in transcription-competent conformation; blood coagulation; rDNA heterochromatin assembly; nucleosome assembly; negative regulation of gene expression, epigenetic; negative regulation of transcription by RNA polymerase II; chromatin organization; regulation of gene silencing by miRNA; interleukin-7-mediated signaling pathway; regulation of megakaryocyte differentiation; regulation of hematopoietic stem cell differentiation;
	Sources:Amigo / QuickGO
Orthologs
	653604
	319148
	ENSG00000183598
	ENSMUSG00000069310
	Q71DI3
	P84228
	NM_001123375
	NM_175653
	NP_066403; NP_001116847
NP_473386; NP_835734; NP_783584; NP_835510; NP_835587;
	NP_038576; NP_835511; NP_835512
	Wikidata
View/Edit Human	View/Edit Mouse

Histone cluster 2 H3 family member d is a protein that in humans is encoded by the HIST2H3D gene. ^[5]

Function

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. [provided by RefSeq, Aug 2015].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183598 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000069310 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Histone cluster 2 H3 family member d". Retrieved 2018-05-17.

Function

References

Further reading