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Hexaminolevulinate

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Hexaminolevulinate
Clinical data
Trade namesCysview, Hexvix
License data
ATC code
Legal status
Legal status
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CAS Number
PubChem CID
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KEGG
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CompTox Dashboard (EPA)

Hexaminolevulinate, sold under the brand name Cysview among others, is an imaging agent that lights up under blue light during a blue light cystoscopy. It is used to help detect non-muscle invasive bladder cancer (NMIBC), in particular papillary tumors and carcinoma in situ (CIS).

It made by Photocure ASA, a Norwegian pharmaceutical company.

Hexaminolevulinate is a structural analogue to 5-aminolevulinic acid (a precursor to the porphyrin ring of heme), and is internalized and processed into the photoactive protoporphyrin IX at a high rate by tumor cells. After exposure to 360-450 nm light, the porphyrin will fluoresce red.[1]

References

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  1. ^ "Prescription medicines: registration of new chemical entities in Australia, 2016". Therapeutic Goods Administration (TGA). 21 June 2022. Retrieved 10 April 2023.
  2. ^ "Cysview- hexaminolevulinate hydrochloride kit". DailyMed. 15 November 2022. Retrieved 10 April 2023.