Heme arginate

Heme arginate
Identifiers
CAS Number	100438-92-4 ;
3D model (JSmol)	Interactive image;
DrugBank	DB17310;
MeSH	Heme+arginate
PubChem CID	3086464;
UNII	R1B526117P ;
	InChI InChI=1S/C34H34N4O4.C6H14N4O2.Fe/c1-7-21-17(3)25-13-26-19(5)23(9-11-33(39)40)31(37-26)16-32-24(10-12-34(41)42)20(6)28(38-32)15-30-22(8-2)18(4)27(36-30)14-29(21)35-25;7-4(5(11)12)2-1-3-10-6(8)9;/h7-8,13-16,35-36H,1-2,9-12H2,3-6H3,(H,39,40)(H,41,42);4H,1-3,7H2,(H,11,12)(H4,8,9,10);/q;;+2/t;4-;/m.0./s1 Key: MGQITOFVXOEWNL-INZIHYEWSA-N;
	SMILES CC1=C(C2=CC3=NC(=CC4=NC(=CC5=C(C(=C(N5)C=C1N2)C=C)C)C(=C4CCC(=O)O)C)C(=C3C)CCC(=O)O)C=C.C(C[C@@H](C(=O)O)N)CN=C(N)N.[Fe+2];
Properties
Chemical formula	C40H48FeN8O6+2
Molar mass	792.704
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). verify (what is ?) Infobox references

Heme arginate (or haem arginate) is a compound of heme and arginine used in the treatment of acute porphyrias.^[1]^[2] This heme product is only available outside the United States and is equivalent to hematin.^[3]

Heme arginate is a heme compound, whereby L-arginine is added to prevent rapid degradation. It is given intravenously, and its action of mechanism is to reduce the overproduction of δ-aminolevulinic acid, which can cause the acute symptoms in an attack of the acute porphyrias.^[4]

References

^ "HAEM ARGINATE FOR THE ACUTE ATTACK OF PORPHYRIA". Porphyria South Africa. Archived from the original on 2012-03-05.
^ "Treatment of the Acute Attack". European Porphyria Network. Archived from the original on 5 October 2011. Retrieved 28 August 2011.
^ "Panhematin for Acute Porphyria". American Porphyria Foundation. Archived from the original on 12 March 2018. Retrieved 8 July 2016.
^ Volin, L; V Rasi; E Vahtera; R Tenhunen (1988). "Heme arginate: effects on hemostasis" (PDF). Blood. 71 (3): 625–628. doi:10.1182/blood.V71.3.625.625. PMID 3345341. Retrieved 28 August 2011.

[1] "HAEM ARGINATE FOR THE ACUTE ATTACK OF PORPHYRIA". Porphyria South Africa. Archived from the original on 2012-03-05.

[2] "Treatment of the Acute Attack". European Porphyria Network. Archived from the original on 5 October 2011. Retrieved 28 August 2011.

[3] "Panhematin for Acute Porphyria". American Porphyria Foundation. Archived from the original on 12 March 2018. Retrieved 8 July 2016.

[4] Volin, L; V Rasi; E Vahtera; R Tenhunen (1988). "Heme arginate: effects on hemostasis" (PDF). Blood. 71 (3): 625–628. doi:10.1182/blood.V71.3.625.625. PMID 3345341. Retrieved 28 August 2011.

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See also

References