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HLA-A32

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HLA-A32
(MHC Class I, A cell surface antigen)
HLA-A32
About
Proteintransmembrane receptor/ligand
Structureαβ heterodimer
SubunitsHLA-A*3201, β2-microglobulin
Older names"A19"
Subtypes
Subtype
allele
Available structures
A19 *3201
{{{cNick2}}} *32{{{cAllele2}}}
{{{cNick3}}} *32{{{cAllele3}}}
{{{cNick4}}} *32{{{cAllele4}}}
Alleles link-out to IMGT/HLA database at EBI

HLA-A32 (A32) is a human leukocyte antigen serotype within HLA-A serotype group. The serotype is determined by the antibody recognition of α32 subset of HLA-A α-chains. For A32, the alpha "A" chain are encoded by the HLA-A*32 allele group and the β-chain are encoded by B2M locus.[1] This group currently is dominated by A*3201. A32 and A*32 are almost synonymous in meaning. A32 is a split antigen of the broad antigen serotype A19. A32 is a sister serotype of A29, A30, A31, A33, and A74.

Further information: History and naming of human leukocyte antigens


Serotype

[edit]
A32 recognition of some HLA A*32 gene products[2]
A*32 A32 Sample
allele % size (N)
*3201 94 3441

A32 Serotyping efficiency for the predominant allele is good. There are 16 known alleles that result in 15 isoforms of HLA-A32. One isoform may be poorly expressed.[3].

Distribution

[edit]
HLA A*3201 frequencies
Study populationFreq.
 (in %)[4]
Oman11.4
Pakistan Brahui9.2
Italy Sardinia8.7
Bulgaria8.2
Burkina Faso Fulani8.2
Pakistan Karachi Parsi7.8
Pakistan Kalash7.5
France South East7.2
Pakistan Baloch7.1
Greece North7.0
Georgia Tbilisi Kurds6.7
Iran Baloch6.7
Spain North Cantabrian6.0
Italy Bergamo5.9
India North Hindus5.8
Croatia5.7
France Corsica5.5
Scotland Orkney5.5
Sudanese5.5
Spain Eastern Andalusia5.4
Algeria15.1
Azores Santa Maria and Sa…5.1
Pakistan Pathan5.1
Pakistan Sindhi5.1
Romanian5.0
Macedonia4.9
Cape Verde Northwestern I…4.8
Georgia Tbilisi Georgian…4.8
Serbia4.6
Ireland South4.4
England Lancaster4.4
Azores Terceira Island4.3
USA Caucasian pop24.3
Bulgaria Gipsy4.2
Cape Verde Southeastern I…4.0
Israel Arab Druse4.0
Portugal Centre4.0
Burkina Faso Mossi3.8
Guinea Bissau3.8
Spain North Cabuernigo3.8
Belgium3.7
Russia Chuvash3.7
Sweden Stockholm3.5
Wales3.5
England Sheffield3.5
England Leeds3.4
Australia New South Wales3.4
Morocco Berber Nador Meta…3.4
Ireland Northern3.2
Jordan Amman3.1
India Khandesh Pawra3.0
India New Delhi3.0
India West Coast Parsis3.0
USA Hispanic3.0
Turkey2.8
Sweden Uppsala County2.7
India North Delhi2.7
Morocco2.7
Pakistan Burusho2.7
Kenya Luo2.6
South African Natal Zulu2.5
China North Han2.4
Czech Republic2.4
London Ashkenazi Jews2.4
Mexico Mestizos2.4
Saudi Arabia Guraiat and …2.4
China Beijing2.2
Finland2.2
Uganda Kampala2.2
Russia Tuva pop 22.1
USA North American Native…2.1
Brazil2.0
Cameroon Beti2.0
Peru Arequipa2.0
Russia Arkhangelsk Pomors2.0
Italy North pop 11.9
Russia Northwest1.8
German Essen1.8
Spain Pas Valley1.6
USA African America1.6
Tunisia1.5
Georgia Svaneti Svans1.3
New Caledonia1.2
South Africa Tswana1.2
Allele frequencies presented, only

A32 is most common around the Persian Gulf and the Mediterranean Basin. It has a consistent presence in Europe. The A32 frequencies in the more isolated (genetically) peoples of Europe suggests that the A32 rise in the Mediterranean may only be partially attributable to recent migrations from the middle eastern region. There is a node in southern Europe around the Ionian Sea in which specific, European, A32-haplotypes are elevated.

Haplotypes

[edit]
HLA A32 haplotype frequencies
freq
ref. Population (%)
A32-B7
(A*3201:B*0702)
Albanian 2.2
Cuban 1.9
[5] Natal Zulu (S. Africa) 1.0
Cretan 0.7
Cretan 0.2
A32-B8
(A*3201:B*0801)
N. Portugal 2.2
Oman 1.8
A32-B14
(A*3201:B*14)
!kung 1.9
Tunis 1.8
Natal Zulu (S. Africa) 1.0
Portugal 1.1
Irish 0.7
Italian 0.6
A32-B27
(A*3201:B27)
Gypsy(Spanish) 6.0
E Black Sea (Turkey) 2.3
German 0.3
A32-B35
(A*3201:C*0401:B*3501)
Greek 3.5
UA Emirates 2.8
Sardinian 2.6
Brahui (Pakistan) 2.5
Tunisia 1.8
Armenian 1.7
Italian 1.5
Oman 1.3
Portugal 1.1
German 0.3
A32-B61(40)
(A*3201:B*40)
Tunis 1.2
Greek 1.2
French 0.6
German 0.4
A32-B44
(A*3201:B*4402)
Austrian 2.4
Belgium 2.0
Albanian 1.8
S. Portugal 1.0
Irish 0.7
German 0.6
Dutch 0.6
Senegal 0.5
Italian 0.4
A32-B51
(A*3201:C*1201:B*5101)
Bulgarian 1.8
German 0.3
(A*3201:C*1502:B*5101)
Oman 5.0
Baloch (Pakistan) 3.2
Kalash 2.9
UA Emirates 1.9
Baloch (Iran) 1.1
(A*3201:C*1401:B*5101)
Parsis (Karachi) 4.9
Kalash 2.9

A common A32 haplotype A*3201-B*5101 can be found in Oman, United Arab Emirates, SE Iran, Bulgaria, and Portugal. A second, A*3201-B*3501 can be in the Omani, UAE, and Portugal.

References

[edit]
  1. ^ Arce-Gomez B, Jones EA, Barnstable CJ, Solomon E, Bodmer WF (February 1978). "The genetic control of HLA-A and B antigens in somatic cell hybrids: requirement for beta2 microglobulin". Tissue Antigens. 11 (2): 96–112. doi:10.1111/j.1399-0039.1978.tb01233.x. PMID 77067.
  2. ^ Allele Query Form IMGT/HLA - European Bioinformatics Institute
  3. ^ Tang TF, Hou L, Tu B, et al. (2006). "Identification of nine new HLA class I alleles in volunteers from the Singapore stem cell donor registries". Tissue Antigens. 68 (6): 518–20. doi:10.1111/j.1399-0039.2006.00707.x. PMID 17176443.
  4. ^ Middleton, D.; Menchaca, L.; Rood, H.; Komerofsky, R. (2003). "New allele frequency database: http://www.allelefrequencies.net". Tissue Antigens. 61 (5): 403–407. doi:10.1034/j.1399-0039.2003.00062.x. PMID 12753660.
  5. ^ B*0705
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