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Protein-coding gene in humans
Hepatocyte growth factor activator is a protein that in humans is encoded by the HGFAC gene .[ 5] [ 6] [ 7]
The protein encoded by this gene, belongs to peptidase family S1. It is first synthesized as an inactive single-chain precursor before being activated to a heterodimeric form by endoproteolytic processing. It acts as serine protease that converts hepatocyte growth factor to the active form.[ 7]
^ a b c GRCh38: Ensembl release 89: ENSG00000109758 – Ensembl , May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029102 – Ensembl , May 2017
^ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
^ Miyazawa K, Shimomura T, Kitamura A, Kondo J, Morimoto Y, Kitamura N (Jun 1993). "Molecular Cloning and Sequence Analysis of the cDNA for a Human Serine Protease Responsible for Activation of Hepatocyte Growth Factor. Structural similarity of the protease precursor to blood coagulation factor XII" . J Biol Chem . 268 (14): 10024–8. doi :10.1016/S0021-9258(18)82167-6 . PMID 7683665 .
^ Shimomura T, Kondo J, Ochiai M, Naka D, Miyazawa K, Morimoto Y, Kitamura N (Dec 1993). "Activation of the zymogen of hepatocyte growth factor activator by thrombin" . J Biol Chem . 268 (30): 22927–32. doi :10.1016/S0021-9258(18)41615-8 . PMID 8226803 .
^ a b "Entrez Gene: HGFAC HGF activator" .
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