HES5

HES5
Identifiers
Aliases	HES5, bHLHb38, hes family bHLH transcription factor 5
External IDs	OMIM: 607348; MGI: 104876; HomoloGene: 7755; GeneCards: HES5; OMA:HES5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p36.32 Start 2,528,745 bp End 2,530,263 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4 E2|4 86.01 cM Start 155,045,380 bp End 155,046,828 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad ventricular zone ganglionic eminence nucleus accumbens amygdala hypothalamus apex of heart anterior cingulate cortex caudate nucleus putamen Top expressed in medial ganglionic eminence Rostral migratory stream ventricular zone somite neural tube substantia nigra thin ascending limb of loop of Henle supraoptic nucleus olfactory bulb lateral septal nucleus More reference expression data BioGPS n/a
Gene ontology Molecular function DNA binding protein dimerization activity transcription factor binding chromatin binding DNA-binding transcription repressor activity, RNA polymerase II-specific double-stranded DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription corepressor activity sequence-specific DNA binding sequence-specific double-stranded DNA binding Cellular component nucleoplasm nucleus cellular component Biological process Notch signaling pathway auditory receptor cell fate determination establishment of epithelial cell polarity cell differentiation negative regulation of astrocyte differentiation regulation of inner ear auditory receptor cell differentiation regulation of transcription, DNA-templated negative regulation of neuron differentiation inner ear receptor cell stereocilium organization comma-shaped body morphogenesis metanephric nephron tubule morphogenesis chondrocyte differentiation central nervous system myelination negative regulation of transcription by RNA polymerase II cell maturation negative regulation of forebrain neuron differentiation transcription, DNA-templated nervous system development negative regulation of stem cell differentiation neuronal stem cell population maintenance positive regulation of transcription, DNA-templated multicellular organism development glial cell fate commitment telencephalon development brain development inner ear auditory receptor cell differentiation cell adhesion astrocyte differentiation cartilage development forebrain radial glial cell differentiation regulation of myelination negative regulation of oligodendrocyte differentiation S-shaped body morphogenesis neural tube development neuron differentiation positive regulation of cell population proliferation positive regulation of BMP signaling pathway negative regulation of pro-B cell differentiation regulation of cell differentiation smoothened signaling pathway oligodendrocyte development camera-type eye development specification of loop of Henle identity regulation of epithelial cell proliferation negative regulation of transcription, DNA-templated negative regulation of inner ear receptor cell differentiation regulation of neurogenesis positive regulation of receptor signaling pathway via JAK-STAT positive regulation of Notch signaling pathway positive regulation of transcription by RNA polymerase II positive regulation of smooth muscle cell proliferation positive regulation of tyrosine phosphorylation of STAT protein protein-containing complex assembly somitogenesis central nervous system development anterior/posterior pattern specification negative regulation of inner ear auditory receptor cell differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 388585 15208 Ensembl ENSG00000273529 ENSG00000197921 ENSMUSG00000048001 UniProt Q5TA89 P70120 RefSeq (mRNA) NM_001010926 NM_010419 NM_001370755 RefSeq (protein) NP_001010926 NP_034549 NP_001357684 Location (UCSC) Chr 1: 2.53 – 2.53 Mb Chr 4: 155.05 – 155.05 Mb PubMed search
Wikidata
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Transcription factor HES-5 is a protein that in humans is encoded by the HES5 gene.

HES5 regulates the development of the early brain by maintaining stem cell neural progenitors in the ventricular zone. HES5 expression significantly higher in squamous cervical carcinoma than in CIN as well as higher in CIN than normal cervical epithelia. Human HES5 gene binds to Notch receptor and expression of HES5 decreases during cartilage differentiation.

Further reading

• Gazit R, Krizhanovsky V, Ben-Arie N (February 2004). "Math1 controls cerebellar granule cell differentiation by regulating multiple components of the Notch signaling pathway". Development. 131 (4): 903–913. doi:10.1242/dev.00982. PMID 14757642. S2CID 44769279.
• Nakatani T, Mizuhara E, Minaki Y, Sakamoto Y, Ono Y (April 2004). "Helt, a novel basic-helix-loop-helix transcriptional repressor expressed in the developing central nervous system". The Journal of Biological Chemistry. 279 (16): 16356–16367. doi:10.1074/jbc.M311740200. PMID 14764602.
• Kamakura S, Oishi K, Yoshimatsu T, Nakafuku M, Masuyama N, Gotoh Y (June 2004). "Hes binding to STAT3 mediates crosstalk between Notch and JAK-STAT signalling". Nature Cell Biology. 6 (6): 547–554. doi:10.1038/ncb1138. PMID 15156153. S2CID 36887899.
• Katoh M, Katoh M (August 2004). "Identification and characterization of human HES2, HES3, and HES5 genes in silico". International Journal of Oncology. 25 (2): 529–534. doi:10.3892/ijo.25.2.529. PMID 15254753.
• Ohtsuka T, Imayoshi I, Shimojo H, Nishi E, Kageyama R, McConnell SK (January 2006). "Visualization of embryonic neural stem cells using Hes promoters in transgenic mice". Molecular and Cellular Neurosciences. 31 (1): 109–122. doi:10.1016/j.mcn.2005.09.006. PMID 16214363. S2CID 35470002.
• Ong CT, Cheng HT, Chang LW, Ohtsuka T, Kageyama R, Stormo GD, Kopan R (February 2006). "Target selectivity of vertebrate notch proteins. Collaboration between discrete domains and CSL-binding site architecture determines activation probability". The Journal of Biological Chemistry. 281 (8): 5106–5119. doi:10.1074/jbc.M506108200. PMID 16365048.
• Karlsson C, Brantsing C, Svensson T, Brisby H, Asp J, Tallheden T, Lindahl A (February 2007). "Differentiation of human mesenchymal stem cells and articular chondrocytes: analysis of chondrogenic potential and expression pattern of differentiation-related transcription factors". Journal of Orthopaedic Research. 25 (2): 152–163. doi:10.1002/jor.20287. PMID 17072841.
• Karlsson C, Jonsson M, Asp J, Brantsing C, Kageyama R, Lindahl A (March 2007). "Notch and HES5 are regulated during human cartilage differentiation". Cell and Tissue Research. 327 (3): 539–551. doi:10.1007/s00441-006-0307-0. PMID 17093926. S2CID 33749726.

External links

• HES5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.