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Glutamine—phenylpyruvate transaminase

From Wikipedia, the free encyclopedia
glutamine-phenylpyruvate transaminase
Identifiers
EC no.2.6.1.64
CAS no.68518-06-9
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
Gene OntologyAmiGO / QuickGO
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NCBIproteins

In enzymology, a glutamine-phenylpyruvate transaminase (EC 2.6.1.64) is an enzyme that catalyzes the chemical reaction

L-glutamine + phenylpyruvate 2-oxoglutaramate + L-phenylalanine

Thus, the two substrates of this enzyme are L-glutamine and phenylpyruvate, whereas its two products are 2-oxoglutaramate and L-phenylalanine.

This enzyme belongs to the family of transferases, to be specific, the transaminases, that transfer nitrogenous groups. The systematic name of this enzyme class is L-glutamine:phenylpyruvate aminotransferase. Other names in common use include glutamine transaminase K, and glutamine-phenylpyruvate aminotransferase. It employs one cofactor, pyridoxal phosphate.

Structural studies

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As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1YIY and 1YIZ.

References

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  • Cooper AJ (1978). "Purification of soluble and mitochondrial glutamine transaminase K from rat kidney. Use of a sensitive assay involving transamination between L-phenylalanine and alpha-keto-gamma-methiolbutyrate". Anal. Biochem. 89 (2): 451–60. doi:10.1016/0003-2697(78)90374-3. PMID 727444.
  • Cooper AJ, Meister A (1974). "Isolation and properties of a new glutamine transaminase from rat kidney". J. Biol. Chem. 249 (8): 2554–61. doi:10.1016/S0021-9258(19)42765-8. PMID 4822504.