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Glutamic--pyruvic transaminase 2

From Wikipedia, the free encyclopedia
GPT2
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesGPT2, ALT2, GPT 2, MRT49, glutamic pyruvate transaminase (alanine aminotransferase) 2, glutamic--pyruvic transaminase 2, NEDSPM
External IDsOMIM: 138210; MGI: 1915391; HomoloGene: 68832; GeneCards: GPT2; OMA:GPT2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_133443
NM_001142466

NM_173866

RefSeq (protein)

NP_001135938
NP_597700

NP_776291

Location (UCSC)Chr 16: 46.88 – 46.93 MbChr 8: 86.22 – 86.25 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Glutamic--pyruvic transaminase 2 is a protein that in humans is encoded by the GPT2 gene. [5]

Function

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This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver. Activating transcription factor 4 upregulates this gene under metabolic stress conditions in hepatocyte cell lines. A loss of function mutation in this gene has been associated with developmental encephalopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015].

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000166123Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000031700Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Glutamic--pyruvic transaminase 2". Retrieved 2018-05-07.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.