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Georgina Xanthou

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Georgina Xanthou
OccupationImmunologist
AwardsRomain Pauwels Research Excellence Award, European Respiratory Society (2009)
UNESCO Award for Women in Science (2009)
Academic background
EducationBSc in Biomedical Sciences
PhD in Immunology
Alma materNational and Kapodistrian University of Athens
Imperial College London
Academic work
InstitutionsBiomedical Research Foundation of the Academy of Athens

Georgina Xanthou is an immunologist who serves as an associate professor at the Biomedical Research Foundation of the Academy of Athens.[1]

Xanthou's research focuses on autoimmune and allergic diseases, particularly in understanding of immunological mechanisms through which cytokines control T cell pathogenicity towards environmental allergens and self-antigens. She has received awards, including the Romain Pauwels Research Excellence Award by the European Respiratory Society,[2] the Allergopharma Award by the European Academy of Allergy and Clinical Immunology,[3] and the UNESCO L’Oreal Award for Women in Science.[4]

Xanthou serves as a board member on scientific advisory and grant review boards, as well as a peer scientific reviewer for journals, including PNAS, Nature, AJRCCM, European Respiratory Journal.[5]

Education and career

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Xanthou holds a BSc in Biomedical Sciences from the Department of Biology in the National and Kapodistrian University of Athens, and a PhD in Immunology from the University of Athens, Medical School. She completed a European Molecular Biology Organization-funded postdoctoral fellowship in the Division of Biomedical Sciences at the Faculty of Medicine in Imperial College, London.[6]

In 2003, Xanthou was appointed as an instructor in the Cellular Immunology Laboratory at Biomedical Research Foundation Academy of Athens (BRFAA). She became an Assistant Professor in 2007 and has been an Associate Professor and Group Leader since 2019.[7] In 2021-2023, she served as a Visiting Professor/Senior Project Scientist at University of California, Los Angeles.[8]

Research

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Xanthou has published over 50 peer-reviewed articles and book chapters. Her publications have been published in scientific journals, including Cell, Nature Reviews Immunology, Nature Immunology, JEM, JACI, Science-Business eXchange, Faculty of Medicine 1000, Global Medical Discovery Series, PNAS USA.[9]

Xanthou's research focuses on immunology and inflammation, and more specifically on the role of dendritic cells and T cells in the regulation of autoimmune and allergic diseases,[10][11][12][13] as well as cancer. In one of her highly cited articles, she demonstrated that the cytokine, osteopontin has a dual role in allergic airway disease, being pro-inflammatory during initial allergen sensitization and anti-inflammatory during subsequent allergen challenges, and highlighted its potential as a therapeutic target for allergic diseases.[10] Her group has also made contributions to studying the role of the cytokine activin-A in regulating T Cell immune responses in the context of allergy, autoimmunity, and cancer.[14][15][16][17]

Awards and honors

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  • 2008 – Allergopharma Award, EAACI Executive Committee[3]
  • 2009 – UNESCO L’Oreal Award for Women in Science, UNESCO[4]
  • 2009 – Romain Pauwels Research Excellence Award, European Respiratory Society[2]
  • 2012 – Fellow Award, European Federation of Immunologic Societies[1]
  • 2014 – Fellowship, European Respiratory Society

Selected articles

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  • Humbles, Alison A; Lloyd, Clare M; McMillan, Sarah J; Friend, Daniel S; Xanthou, Georgina; McKenna, Erin E; Ghiran, Sorina; Gerard, Norma P; Yu, Channing; Orkin, Stuart H; Gerard, Craig (2004-09-17). "A critical role for eosinophils in allergic airways remodeling". Science. 305 (5691): 1776–1779. doi:10.1126/science.1100283. PMID 15375268. S2CID 13955359.
  • Petrakou, Eutichia; Fotopoulos, Spyros; Anagnostakou, Marina; Anatolitou, Fani; Samitas, Konstantinos; Semitekolou, Maria; Xanthou, Georgina; Xanthou, Marietta (2013-10-16). "Activin-A exerts a crucial anti-inflammatory role in neonatal infections". Pediatric Research. 74 (6): 675–681. doi:10.1038/pr.2013.159. S2CID 8741078.
  • Semitekolou, Maria; Morianos, Ioannis; Banos, Aggelos; Konstantopoulos, Dimitris; Adamou-Tzani, Marina; Sparwasser, Tim; Xanthou, Georgina (2017-06-01). "Dendritic cells conditioned by activin A–induced regulatory T cells exhibit enhanced tolerogenic properties and protect against experimental asthma". The Journal of Allergy and Clinical Immunology. 141 (2): 671–684. doi:10.1016/j.jaci.2017.03.047. S2CID 205614932.
  • Morianos, Ioannis; Trochoutsou, Aikaterini I; Papadopoulou, Gina; Semitekolou, Maria; Banos, Aggelos; Konstantopoulos, Dimitris; Manousopoulou, Antigoni; Kapasa, Maria; Wei, Ping; Lomenick, Brett; Belaidi, Elise; Kalamatas, Themis; Karageorgiou, Klinta; Doskas, Triantafyllos; Sallusto, Federica; Pan, Fan; Garbis, Spiros D; Quintana, Francisco J; Xanthou, Georgina (2020-06-02). "Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-α–dependent pathways". Proceedings of the National Academy of Sciences of the United States of America. 117 (22): 12269–12280. doi:10.1073/pnas.1918196117. PMC 7275751. PMID 32409602. S2CID 218650260.
  • Theofani, Efthymia; Semitekolou, Maria; Samitas, Konstantinos; Mais, Annie; Galani, Ioanna E; Triantafyllia, Vasiliki; Lama, Joanna; Morianos, Ioannis; Stavropoulos, Athanasios; Jeong, Se-Jin; Andreakos, Evangelos; Razani, Babak; Rovina, Nikoletta; Xanthou, Georgina (July 2022). "TFEB signaling attenuates NLRP3‐driven inflammatory responses in severe asthma". Allergy. European Journal of Allergy and Clinical Immunology. 77 (7): 131–2146. doi:10.1111/all.15221. PMID 35038351. S2CID 250118136.

References

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  1. ^ a b "Scientific Personnel - Profile". Biomedical Research Foundation. Academy of Athens.
  2. ^ a b Romain Pauwels Award (supported by GlaxoSmithKline). The ERS International Congress 2009, Vienna. ERS.
  3. ^ a b "Allergopharma Award, EAACI Executive Committee". Allergopharma.
  4. ^ a b "Georgina Xanthou, PhD". The Michael J. Fox Foundation.
  5. ^ "List of European Respiratory Journal peer reviewers 2020".
  6. ^ "Xanthou Georgina- Bio". Information Technologies in Medicine and Biology.
  7. ^ "Xanthou Lab". Biomedical Research Foundation. Academy of Athens.
  8. ^ "Jacobs LabFormer Lab Members". UCLA Health.
  9. ^ "Georgina Xanthou - Google Scholar Profile".
  10. ^ a b Xanthou, Georgina; Alissafi, Themis; Semitekolou, Maria; Simoes, Davina C M; Economidou, Erasmia; Gaga, Mina; Lambrecht, Bart N; Lloyd, Clare M; Panoutsakopoulou, Vily (2007-04-15). "Osteopontin has a crucial role in allergic airway disease through regulation of dendritic cell subsets". Nature Medicine. 13: 570–578. doi:10.1038/nm1580. PMC 3384679. PMID 17435770. S2CID 11289211.
  11. ^ Simoes, Davina C M; Xanthou, Georgina; Petrochilou, Kalomira; Panoutsakopoulou, Vily; Roussos, Charis; Gratziou, Christina (2009-05-15). "Osteopontin Deficiency Protects against Airway Remodeling and Hyperresponsiveness in Chronic Asthma". American Journal of Respiratory and Critical Care Medicine. 179 (10): 894–902. doi:10.1164/rccm.200807-1081OC. PMID 19234104. S2CID 45303355.
  12. ^ Tousa, Sofia; Semitekolou, Maria; Christopoulou, Ioanna; Samitas, Konstantinos; Paraskevopoulos, Giannis; Hawrylowicz, Catherine; Gaga, Mina; Xanthou, Georgina (2011-09-01). "Critical immunoregulatory role for activin-A in human allergic asthma". European Respiratory Journal. 38 (Supplement 55). S2CID 70475520.
  13. ^ Theofani, Efthymia; Semitekolou, Maria; Morianos, Ioannis; Samitas, Konstantinos; Xanthou, Georgina (2019-10-04). "Targeting NLRP3 Inflammasome Activation in Severe Asthma". Journal of Clinical Medicine. 8 (10): 1615. doi:10.3390/jcm8101615. PMC 6833007. S2CID 203924809.
  14. ^ Semitekolou, Maria; Alissafi, Themis; Aggelakopoulou, Maria; Kourepini, Evangelia; Kariyawasam, Harsha H.; Kay, Anthony B.; Robinson, Douglas S.; Lloyd, Clare M.; Panoutsakopoulou, Vily; Xanthou, Georgina (2009-08-03). "Activin-A induces regulatory T cells that suppress T helper cell immune responses and protect from allergic airway disease". Journal of Experimental Medicine. 206 (8): 1769–1785. doi:10.1084/jem.20082603. PMC 2722168. PMID 19620629. S2CID 6442428.
  15. ^ Kariyawasam, Harsha H; Pegorier, Sophie; Barkans, Julia; Xanthou, Georgina; Aizen, Maxine; Ying, Sun; Kay, A. Barry; Lloyd, Clare M.; Robinson, Douglas S. (September 2009). "Activin and transforming growth factor-beta signaling pathways are activated after allergen challenge in mild asthma". The Journal of Allergy and Clinical Immunology. 124 (3): 454–462. doi:10.1016/j.jaci.2009.06.022. PMC 4579560. PMID 19733294. S2CID 3725145.
  16. ^ Sofia, Tousa; Semitekolou, Maria; Morianos, Ioannis; Banos, Aggelos; Trochoutsou, Aikaterini I.; Brodie, Tess M.; Poulos, Nikolaos; Samitas, Konstantinos; Kapasa, Maria; Konstantopoulos, Dimitris; Paraskevopoulos, Giannis; Gaga, Mina; Hawrylowicz, Catherine M.; Sallusto, Federica; Xanthou, Georgina (2017-03-20). "Activin-A co-opts IRF4 and AhR signaling to induce human regulatory T cells that restrain asthmatic responses". Proceedings of the National Academy of Sciences of the United States of America. 114 (14): E2891–E2900. doi:10.1073/pnas.1616942114. PMC 5389328. PMID 28320933. S2CID 4733152.
  17. ^ Morianos, Ioannis; Papadopoulou, Gina; Semitekolou, Maria; Xanthou, Georgina (November 2019). "Activin-A in the regulation of immunity in health and disease". Journal of Autoimmunity. doi:10.1016/j.jaut.2019.102314. PMID 31416681. S2CID 201019116.
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