GFRA2 (gene)

GFRA2
Identifiers
Aliases	GFRA2, GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2, GDNF family receptor alpha 2
External IDs	OMIM: 601956; MGI: 1195462; HomoloGene: 1145; GeneCards: GFRA2; OMA:GFRA2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8p21.3 Start 21,690,398 bp End 21,812,357 bp
Gene location (Mouse) Chr. Chromosome 14 (mouse) Band 14|14 D2 Start 71,127,560 bp End 71,217,278 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Brodmann area 10 left lobe of thyroid gland right lobe of thyroid gland right frontal lobe Brodmann area 9 primary visual cortex cingulate gyrus anterior cingulate cortex testicle Top expressed in left lung lobe median eminence lumbar spinal ganglion ascending aorta aortic valve lateral septal nucleus genital tubercle Gonadal ridge molar arcuate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function glial cell-derived neurotrophic factor receptor activity signaling receptor activity Cellular component anchored component of membrane membrane extrinsic component of membrane plasma membrane intracellular anatomical structure external side of plasma membrane receptor complex Biological process glial cell-derived neurotrophic factor receptor signaling pathway nervous system development transmembrane receptor protein tyrosine kinase signaling pathway MAPK cascade axon guidance positive regulation of peptidyl-serine phosphorylation of STAT protein negative regulation of protein autophosphorylation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2675 14586 Ensembl ENSG00000168546 ENSMUSG00000022103 UniProt O00451 O08842 RefSeq (mRNA) NM_001165038 NM_001165039 NM_001495 NM_008115 NM_001302094 NM_001302095 RefSeq (protein) NP_001158510 NP_001158511 NP_001486 NP_001289023 NP_001289024 NP_032141 Location (UCSC) Chr 8: 21.69 – 21.81 Mb Chr 14: 71.13 – 71.22 Mb PubMed search
Wikidata
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GDNF family receptor alpha-2 (GFRα2), also known as the neurturin receptor, is a protein that in humans is encoded by the GFRA2 gene.

Function

The GFRA2 protein is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. They both bind the GFRA2 receptor. The receptor mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases.

Interactions

GFRA2 (gene) has been shown to interact with GDNF.

See also

• GFRα

Further reading

• Baloh RH, Tansey MG, Golden JP, Creedon DJ, Heuckeroth RO, Keck CL, Zimonjic DB, Popescu NC, Johnson EM, Milbrandt J (May 1997). "TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret". Neuron. 18 (5): 793–802. doi:10.1016/S0896-6273(00)80318-9. PMID 9182803.
• Klein RD, Sherman D, Ho WH, Stone D, Bennett GL, Moffat B, Vandlen R, Simmons L, Gu Q, Hongo JA, Devaux B, Poulsen K, Armanini M, Nozaki C, Asai N, Goddard A, Phillips H, Henderson CE, Takahashi M, Rosenthal A (Jun 1997). "A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor". Nature. 387 (6634): 717–21. Bibcode:1997Natur.387..717K. doi:10.1038/42722. PMID 9192898. S2CID 4360246.
• Suvanto P, Wartiovaara K, Lindahl M, Arumae U, Moshnyakov M, Horelli-Kuitunen N, Airaksinen MS, Palotie A, Sariola H, Saarma M (Aug 1997). "Cloning, mRNA distribution and chromosomal localisation of the gene for glial cell line-derived neurotrophic factor receptor beta, a homologue to GDNFR-alpha". Human Molecular Genetics. 6 (8): 1267–73. doi:10.1093/hmg/6.8.1267. PMID 9259272.
• Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (December 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry. 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. PMID 9407096.
• Tansey MG, Baloh RH, Milbrandt J, Johnson EM (Mar 2000). "GFRalpha-mediated localization of RET to lipid rafts is required for effective downstream signaling, differentiation, and neuronal survival". Neuron. 25 (3): 611–23. doi:10.1016/S0896-6273(00)81064-8. PMID 10774729.
• Cik M, Masure S, Lesage AS, Van Der Linden I, Van Gompel P, Pangalos MN, Gordon RD, Leysen JE (Sep 2000). "Binding of GDNF and neurturin to human GDNF family receptor alpha 1 and 2. Influence of cRET and cooperative interactions". The Journal of Biological Chemistry. 275 (36): 27505–12. doi:10.1074/jbc.M000306200. PMID 10829012.
• Vanhorne JB, Gimm O, Myers SM, Kaushik A, von Deimling A, Eng C, Mulligan LM (May 2001). "Cloning and characterization of the human GFRA2 locus and investigation of the gene in Hirschsprung disease". Human Genetics. 108 (5): 409–15. doi:10.1007/s004390100506. PMID 11409869. S2CID 7677951.
• Yoong LF, Too HP (May 2007). "Glial cell line-derived neurotrophic factor and neurturin inhibit neurite outgrowth and activate RhoA through GFR alpha 2b, an alternatively spliced isoform of GFR alpha 2". The Journal of Neuroscience. 27 (21): 5603–14. doi:10.1523/JNEUROSCI.4552-06.2007. PMC 6672776. PMID 17522305.