Jump to content

GDI2

From Wikipedia, the free encyclopedia

GDI2
Identifiers
AliasesGDI2, HEL-S-46e, RABGDIB, GDP dissociation inhibitor 2
External IDsOMIM: 600767; MGI: 99845; HomoloGene: 37488; GeneCards: GDI2; OMA:GDI2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001494
NM_001115156

NM_008112

RefSeq (protein)

NP_001108628
NP_001485

NP_032138

Location (UCSC)Chr 10: 5.77 – 5.84 MbChr 13: 3.59 – 3.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Rab GDP dissociation inhibitor beta is a protein that in humans is encoded by the GDI2 gene.[5][6]

GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000057608Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021218Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Sedlacek Z, Munstermann E, Mincheva A, Lichter P, Poustka A (Feb 1998). "The human rab GDI beta gene with long retroposon-rich introns maps to 10p15 and its pseudogene to 7p11-p13". Mamm Genome. 9 (1): 78–80. doi:10.1007/s003359900685. PMID 9434952. S2CID 36441100.
  6. ^ a b "Entrez Gene: GDI2 GDP dissociation inhibitor 2".

Further reading

[edit]