GBF1

GBF1
Identifiers
Aliases	GBF1, ARF1GEF, golgi brefeldin A resistant guanine nucleotide exchange factor 1, CMT2GG
External IDs	OMIM: 603698; MGI: 1861607; HomoloGene: 37897; GeneCards: GBF1; OMA:GBF1 - orthologs
Gene location (Human) Chr. Chromosome 10 (human) Band 10q24.32 Start 102,245,371 bp End 102,382,899 bp
Gene location (Mouse) Chr. Chromosome 19 (mouse) Band 19|19 C3 Start 46,140,948 bp End 46,274,949 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in epithelium of colon ventricular zone anterior pituitary sural nerve stromal cell of endometrium ganglionic eminence right lobe of thyroid gland apex of heart mucosa of transverse colon right hemisphere of cerebellum Top expressed in neural layer of retina zygote tail of embryo lacrimal gland secondary oocyte genital tubercle muscle of thigh seminiferous tubule molar parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphatidylinositol-3,5-bisphosphate binding protein binding guanyl-nucleotide exchange factor activity phosphatidylinositol-3,4,5-trisphosphate binding lipid binding Cellular component lipid droplet Golgi membrane trans-Golgi network cell leading edge peroxisome cytoplasm endoplasmic reticulum lumen Golgi stack mitochondrion cytosol Golgi apparatus membrane cis-Golgi network endoplasmic reticulum-Golgi intermediate compartment Biological process Golgi disassembly protein localization to endoplasmic reticulum tubular network retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum protein transport Golgi organization viral process regulation of mitotic cell cycle endoplasmic reticulum-Golgi intermediate compartment organization post-Golgi vesicle-mediated transport establishment of monopolar cell polarity protein localization to endoplasmic reticulum exit site regulation of protein localization to cell surface endoplasmic reticulum to Golgi vesicle-mediated transport cell activation involved in immune response protein localization to Golgi apparatus neutrophil chemotaxis reactive oxygen species biosynthetic process retrograde transport, endosome to Golgi Golgi to endosome transport regulation of ARF protein signal transduction COPI coating of Golgi vesicle transport regulation of molecular function Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8729 107338 Ensembl ENSG00000107862 ENSMUSG00000025224 UniProt Q92538 n/a RefSeq (mRNA) NM_001199378 NM_001199379 NM_004193 NM_001377137 NM_001377138 NM_001377139 NM_001377140 NM_001377141 NM_001391922 NM_001391923 NM_001391924 NM_001391925 NM_001391926 NM_001391927 NM_001391928 NM_001391929 NM_001391930 NM_001391931 NM_178930 RefSeq (protein) NP_001186307 NP_001186308 NP_004184 n/a Location (UCSC) Chr 10: 102.25 – 102.38 Mb Chr 19: 46.14 – 46.27 Mb PubMed search
Wikidata
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Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 is a protein that in humans is encoded by the GBF1 gene.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• Claude A, Zhao BP, Kuziemsky CE, et al. (1999). "GBF1: A novel Golgi-associated BFA-resistant guanine nucleotide exchange factor that displays specificity for ADP-ribosylation factor 5". J. Cell Biol. 146 (1): 71–84. doi:10.1083/jcb.146.1.71. PMC 2199737. PMID 10402461.
• Kawamoto K, Yoshida Y, Tamaki H, et al. (2003). "GBF1, a guanine nucleotide exchange factor for ADP-ribosylation factors, is localized to the cis-Golgi and involved in membrane association of the COPI coat". Traffic. 3 (7): 483–95. doi:10.1034/j.1600-0854.2002.30705.x. PMID 12047556. S2CID 45336536.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• García-Mata R, Sztul E (2003). "The membrane-tethering protein p115 interacts with GBF1, an ARF guanine-nucleotide-exchange factor". EMBO Rep. 4 (3): 320–5. doi:10.1038/sj.embor.embor762. PMC 1315890. PMID 12634853.
• Claude A, Zhao BP, Melançon P (2003). "Characterization of alternatively spliced and truncated forms of the Arf guanine nucleotide exchange factor GBF1 defines regions important for activity". Biochem. Biophys. Res. Commun. 303 (1): 160–9. doi:10.1016/S0006-291X(03)00316-4. hdl:10533/173991. PMID 12646181.
• Deloukas P, Earthrowl ME, Grafham DV, et al. (2004). "The DNA sequence and comparative analysis of human chromosome 10". Nature. 429 (6990): 375–81. Bibcode:2004Natur.429..375D. doi:10.1038/nature02462. PMID 15164054.
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
• Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Niu TK, Pfeifer AC, Lippincott-Schwartz J, Jackson CL (2005). "Dynamics of GBF1, a Brefeldin A-sensitive Arf1 exchange factor at the Golgi". Mol. Biol. Cell. 16 (3): 1213–22. doi:10.1091/mbc.E04-07-0599. PMC 551486. PMID 15616190.
• Szul T, Garcia-Mata R, Brandon E, et al. (2005). "Dissection of membrane dynamics of the ARF-guanine nucleotide exchange factor GBF1". Traffic. 6 (5): 374–85. doi:10.1111/j.1600-0854.2005.00282.x. PMID 15813748. S2CID 23845874.
• Roy SK, Hu J, Meng Q, et al. (2006). "Development of monoclonal antibodies against GBF1 and their use in studying its functions". J. Interferon Cytokine Res. 25 (11): 666–73. doi:10.1089/jir.2005.25.666. PMID 16318580.
• Nousiainen M, Silljé HH, Sauer G, et al. (2006). "Phosphoproteome analysis of the human mitotic spindle". Proc. Natl. Acad. Sci. U.S.A. 103 (14): 5391–6. Bibcode:2006PNAS..103.5391N. doi:10.1073/pnas.0507066103. PMC 1459365. PMID 16565220.
• Zhao X, Claude A, Chun J, et al. (2006). "GBF1, a cis-Golgi and VTCs-localized ARF-GEF, is implicated in ER-to-Golgi protein traffic". J. Cell Sci. 119 (Pt 18): 3743–53. doi:10.1242/jcs.03173. PMID 16926190.
• Belov GA, Altan-Bonnet N, Kovtunovych G, et al. (2007). "Hijacking components of the cellular secretory pathway for replication of poliovirus RNA". J. Virol. 81 (2): 558–67. doi:10.1128/JVI.01820-06. PMC 1797456. PMID 17079330.