Alpha-5 beta-1

α₅β₁, also known as the fibronectin receptor,^[1] is an integrin that binds to matrix macromolecules and proteinases and thereby stimulates angiogenesis.^[2] It is composed of α₅ (ITGA5/CD49e) and β₁ (ITGB1/CD29) subunits. It is the primary receptor for fibronectin. The interaction of VLA-5 with fibronectin plays an important role in regulating inflammatory cytokine production by human articular chondrocytes (From the Cell Migration Gateway ITGA5 ITGB1).

α₅β₁-integrin is transported inside the cell by the kinesin KIF1C,^[3] a kinesin-3 organelle transporter that walks along microtubules.

References

^ Schaffner, F.; Ray, A.; Dontenwill, M. (2013). "Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors". Cancers. 5 (4): 27–47. doi:10.3390/cancers5010027. PMC 3730317.
^ Boudreau NJ, Varner JA (February 2004). "The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis". J. Biol. Chem. 279 (6): 4862–8. doi:10.1074/jbc.M305190200. PMID 14610084.
^ Theisen, U; Straube, E; Straube, A (Dec 11, 2012). "Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions". Developmental Cell. 23 (6): 1153–66. doi:10.1016/j.devcel.2012.11.005. PMID 23237952.

External links

Integrin+alpha5beta1 at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
ITGA5 ITGB1 Info with links in the Cell Migration Gateway

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[1] Schaffner, F.; Ray, A.; Dontenwill, M. (2013). "Integrin α5β1, the Fibronectin Receptor, as a Pertinent Therapeutic Target in Solid Tumors". Cancers. 5 (4): 27–47. doi:10.3390/cancers5010027. PMC 3730317.

[pmid14610084-2] Boudreau NJ, Varner JA (February 2004). "The homeobox transcription factor Hox D3 promotes integrin alpha5beta1 expression and function during angiogenesis". J. Biol. Chem. 279 (6): 4862–8. doi:10.1074/jbc.M305190200. PMID 14610084.

[3] Theisen, U; Straube, E; Straube, A (Dec 11, 2012). "Directional persistence of migrating cells requires Kif1C-mediated stabilization of trailing adhesions". Developmental Cell. 23 (6): 1153–66. doi:10.1016/j.devcel.2012.11.005. PMID 23237952.

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