Fas associated factor family member 2

FAF2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2DAM
Identifiers
Aliases	FAF2, ETEA, UBXD8, UBXN3B, Fas associated factor family member 2
External IDs	OMIM: 616935; MGI: 1923827; HomoloGene: 8753; GeneCards: FAF2; OMA:FAF2 - orthologs
Gene location (Human)
Chr.	Chromosome 5 (human)
End	176,510,074 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	54,811,876 bp
RNA expression pattern
	Top expressed in
	parotid gland; ; gingival epithelium; ; tibia; ; caput epididymis; ; corpus epididymis; ; tail of epididymis; ; parietal pleura; ; visceral pleura; ; inferior olivary nucleus; ; islet of Langerhans;
	Top expressed in
	spermatocyte; ; spermatid; ; yolk sac; ; right kidney; ; otolith organ; ; interventricular septum; ; utricle; ; tail of embryo; ; neural tube; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	lipase inhibitor activity; ubiquitin binding; protein binding; lipase binding; ubiquitin protein ligase binding;
Cellular component	VCP-NPL4-UFD1 AAA ATPase complex; cytoplasm; lipid droplet; endoplasmic reticulum; extracellular region; azurophil granule lumen;
Biological process	response to unfolded protein; retrograde protein transport, ER to cytosol; ubiquitin-dependent ERAD pathway; lipid droplet organization; negative regulation of catalytic activity; neutrophil degranulation; proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
	23197
	76577
	ENSG00000113194
	ENSMUSG00000025873
	Q96CS3
	Q3TDN2
	NM_014613
	NM_178397
	NP_055428
	NP_848484
	Wikidata
View/Edit Human	View/Edit Mouse

Fas associated factor family member 2 is a protein that in humans is encoded by the FAF2 gene. ^[5]

Function

The protein encoded by this gene is highly expressed in peripheral blood of patients with atopic dermatitis (AD), compared to normal individuals. It may play a role in regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients. [provided by RefSeq, Jul 2008].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000113194 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025873 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Fas associated factor family member 2". Retrieved 2018-07-21.

Imai Y, Nakada A, Hashida R, Sugita Y, Tanaka T, Tsujimoto G, Matsumoto K, Akasawa A, Saito H, Oshida T (October 2002). "Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients". Biochem. Biophys. Res. Commun. 297 (5): 1282–90. doi:10.1016/s0006-291x(02)02380-x. PMID 12372427.
Phan VT, Ding VW, Li F, Chalkley RJ, Burlingame A, McCormick F (May 2010). "The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans". Mol. Cell. Biol. 30 (9): 2264–79. doi:10.1128/MCB.01450-08. PMC 2863595. PMID 20160012.
Lee JN, Kim H, Yao H, Chen Y, Weng K, Ye J (December 2010). "Identification of Ubxd8 protein as a sensor for unsaturated fatty acids and regulator of triglyceride synthesis". Proc. Natl. Acad. Sci. U.S.A. 107 (50): 21424–9. Bibcode:2010PNAS..10721424L. doi:10.1073/pnas.1011859107. PMC 3003070. PMID 21115839.
Suzuki M, Otsuka T, Ohsaki Y, Cheng J, Taniguchi T, Hashimoto H, Taniguchi H, Fujimoto T (March 2012). "Derlin-1 and UBXD8 are engaged in dislocation and degradation of lipidated ApoB-100 at lipid droplets". Mol. Biol. Cell. 23 (5): 800–10. doi:10.1091/mbc.E11-11-0950. PMC 3290640. PMID 22238364.
Wang CW, Lee SC (June 2012). "The ubiquitin-like (UBX)-domain-containing protein Ubx2/Ubxd8 regulates lipid droplet homeostasis". J. Cell Sci. 125 (Pt 12): 2930–9. doi:10.1242/jcs.100230. PMID 22454508.
Olzmann JA, Richter CM, Kopito RR (January 2013). "Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover". Proc. Natl. Acad. Sci. U.S.A. 110 (4): 1345–50. Bibcode:2013PNAS..110.1345O. doi:10.1073/pnas.1213738110. PMC 3557085. PMID 23297223.
Kim H, Zhang H, Meng D, Russell G, Lee JN, Ye J (August 2013). "UAS domain of Ubxd8 and FAF1 polymerizes upon interaction with long-chain unsaturated fatty acids". J. Lipid Res. 54 (8): 2144–52. doi:10.1194/jlr.M037218. PMC 3708364. PMID 23720822.
Kim H, Ye J (April 2014). "Cellular responses to excess fatty acids: focus on ubiquitin regulatory X domain-containing protein 8". Curr. Opin. Lipidol. 25 (2): 118–24. doi:10.1097/MOL.0000000000000048. PMID 24378746. S2CID 34713444.
Schrul B, Kopito RR (July 2016). "Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains". Nat. Cell Biol. 18 (7): 740–51. doi:10.1038/ncb3373. PMC 4925261. PMID 27295553.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 5 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000113194 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025873 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Fas associated factor family member 2". Retrieved 2018-07-21.

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Function

References

Further reading