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Family with sequence similarity 19 (chemokine (C-C motif)-like), member A1

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TAFA1
Identifiers
AliasesTAFA1, TAFA-1, Family with sequence similarity 19 (chemokine (C-C motif)-like), member A1, family with sequence similarity 19 member A1, C-C motif chemokine like, FAM19A1, TAFA chemokine like family member 1
External IDsOMIM: 617495; MGI: 2443695; HomoloGene: 45655; GeneCards: TAFA1; OMA:TAFA1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_213609
NM_001252216

NM_182808

RefSeq (protein)

NP_001239145
NP_998774

NP_877960

Location (UCSC)Chr 3: 68 – 68.55 MbChr 6: 96.09 – 96.63 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein FAM19A1 is a protein that in humans is encoded by the FAM19A1 gene.[5][6]

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells.[6]

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000183662Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059187Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics. 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294.
  6. ^ a b "Entrez Gene: FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1".

Further reading

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