Family with sequence similarity 19 (chemokine (C-C motif)-like), member A1

TAFA1
Identifiers
Aliases	TAFA1, TAFA-1, Family with sequence similarity 19 (chemokine (C-C motif)-like), member A1, family with sequence similarity 19 member A1, C-C motif chemokine like, FAM19A1, TAFA chemokine like family member 1
External IDs	OMIM: 617495; MGI: 2443695; HomoloGene: 45655; GeneCards: TAFA1; OMA:TAFA1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	68,545,621 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	96,634,159 bp
RNA expression pattern
	Top expressed in
	middle temporal gyrus; ; endothelial cell; ; Brodmann area 23; ; Pons; ; Brodmann area 46; ; superior frontal gyrus; ; entorhinal cortex; ; postcentral gyrus; ; primary visual cortex; ; dorsolateral prefrontal cortex;
	Top expressed in
	piriform cortex; ; subdivision of hippocampus; ; Region I of hippocampus proper; ; hippocampus proper; ; lumbar spinal ganglion; ; dentate gyrus; ; pontine nuclei; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; Amygdala;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; receptor ligand activity;
Cellular component	endoplasmic reticulum; extracellular region; extracellular space;
Biological process	regulation of signaling receptor activity; neuroblast differentiation; regulation of neuroblast proliferation; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	407738
	320265
	ENSG00000183662
	ENSMUSG00000059187
	Q7Z5A9
	Q7TPG8
	NM_213609; NM_001252216
	NM_182808
	NP_001239145; NP_998774
	NP_877960
	Wikidata
View/Edit Human	View/Edit Mouse

Protein FAM19A1 is a protein that in humans is encoded by the FAM19A1 gene.^[5]^[6]

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000183662 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059187 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics. 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294.
^ ^a ^b "Entrez Gene: FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1".

Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000183662 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000059187 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid15028294-5] Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics. 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294.

[entrez-6] "Entrez Gene: FAM19A1 family with sequence similarity 19 (chemokine (C-C motif)-like), member A1".

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References

Further reading