FKBPL

FKBPL
Identifiers
Aliases	FKBPL, DIR1, NG7, WISP39, FKBP4, FK506 binding protein like, FKBP prolyl isomerase like
External IDs	OMIM: 617076; MGI: 1932127; HomoloGene: 10529; GeneCards: FKBPL; OMA:FKBPL - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	32,130,288 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	34,865,298 bp
RNA expression pattern
	Top expressed in
	testicle; ; gonad; ; skin of leg; ; granulocyte; ; skin of abdomen; ; mucosa of transverse colon; ; islet of Langerhans; ; apex of heart; ; body of stomach; ; blood;
	Top expressed in
	seminiferous tubule; ; spermatid; ; spermatocyte; ; primary oocyte; ; granulocyte; ; muscle of thigh; ; embryo; ; right kidney; ; secondary oocyte; ; embryo;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytosol; extracellular region;
Biological process	response to radiation; protein stabilization; regulation of angiogenesis; regulation of blood vessel branching;
	Sources:Amigo / QuickGO
Orthologs
	63943
	56299
	ENSG00000204315; ENSG00000230907; ENSG00000224200; ENSG00000223666
	ENSMUSG00000033739
	Q9UIM3
	O35450
	NM_022110
	NM_019873
	NP_071393; NP_071393.2
	NP_063926
	Wikidata
View/Edit Human	View/Edit Mouse

FK506-binding protein like, also known as FKBPL, is a protein that in humans is encoded by the FKBPL gene.^[5]

Function

FKBPL has similarity to the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. The encoded protein is thought to have a potential role in the induced radioresistance. Also it appears to have some involvement in the control of the cell cycle.^[6]

FKBPL is involved in cellular response to stress. It was first isolated in 1999 and was initially named DIR1.^[7] It was later reclassified because of its homology to the FKBP family of proteins and was renamed FKBP-like (FKBPL). A separate study that found it to be involved in the stabilisation of newly synthesised p21 termed it Wisp39.^[8]

It is known to interact with Hsp90, glucocorticoid receptor and dynamitin and may play a role in signalling, like other FKBPs.^[9]

FKBPL has also been shown to influence estrogen receptor signalling and can have a determinant effect on response to the breast cancer drug tamoxifen.^[10]

References

^ ^a ^b ^c ENSG00000230907, ENSG00000224200, ENSG00000223666 GRCh38: Ensembl release 89: ENSG00000204315, ENSG00000230907, ENSG00000224200, ENSG00000223666 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033739 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Robson TA, Lohrer H, Bailie JR, Hirst DG, Joiner MC, Arrand JE (February 1997). "Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line". Biochem. Soc. Trans. 25 (1): 335–42. doi:10.1042/bst0250335. PMID 9056895.
^ "Entrez Gene: FKBPL".
^ Robson T, Joiner MC, Wilson GD, McCullough W, Price ME, Logan I, Jones H, McKeown SR, Hirst DG (November 1999). "A novel human stress response-related gene with a potential role in induced radioresistance". Radiat. Res. 152 (5): 451–61. Bibcode:1999RadR..152..451R. doi:10.2307/3580140. JSTOR 3580140. PMID 10521921.
^ Jascur T, Brickner H, Salles-Passador I, Barbier V, El Khissiin A, Smith B, Fotedar R, Fotedar A (January 2005). "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein". Mol. Cell. 17 (2): 237–49. doi:10.1016/j.molcel.2004.11.049. PMID 15664193.
^ McKeen HD, McAlpine K, Valentine A, Quinn DJ, McClelland K, Byrne C, O'Rourke M, Young S, Scott CJ, McCarthy HO, Hirst DG, Robson T (July 2008). "A novel FK506-like binding protein (FKBPL) interacts with the glucocorticoid receptor and regulates steroid receptor signalling". Endocrinology. 149 (11): 5724–34. doi:10.1210/en.2008-0168. PMID 18669603. S2CID 32563192.
^ McKeen HD, Byrne C, Jithesh PV, Donley C, Valentine A, Yakkundi A, O'Rourke M, Swanton C, McCarthy HO, Hirst DG, Robson T (February 2010). "FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy". Cancer Res. 70 (3): 1090–100. doi:10.1158/0008-5472.CAN-09-2515. PMID 20103631.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] ENSG00000230907, ENSG00000224200, ENSG00000223666 GRCh38: Ensembl release 89: ENSG00000204315, ENSG00000230907, ENSG00000224200, ENSG00000223666 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033739 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9056895-5] Robson TA, Lohrer H, Bailie JR, Hirst DG, Joiner MC, Arrand JE (February 1997). "Gene regulation by low-dose ionizing radiation in a normal human lung epithelial cell line". Biochem. Soc. Trans. 25 (1): 335–42. doi:10.1042/bst0250335. PMID 9056895.

[entrez-6] "Entrez Gene: FKBPL".

[pmid10521921-7] Robson T, Joiner MC, Wilson GD, McCullough W, Price ME, Logan I, Jones H, McKeown SR, Hirst DG (November 1999). "A novel human stress response-related gene with a potential role in induced radioresistance". Radiat. Res. 152 (5): 451–61. Bibcode:1999RadR..152..451R. doi:10.2307/3580140. JSTOR 3580140. PMID 10521921.

[pmid15664193-8] Jascur T, Brickner H, Salles-Passador I, Barbier V, El Khissiin A, Smith B, Fotedar R, Fotedar A (January 2005). "Regulation of p21(WAF1/CIP1) stability by WISp39, a Hsp90 binding TPR protein". Mol. Cell. 17 (2): 237–49. doi:10.1016/j.molcel.2004.11.049. PMID 15664193.

[pmid18669603-9] McKeen HD, McAlpine K, Valentine A, Quinn DJ, McClelland K, Byrne C, O'Rourke M, Young S, Scott CJ, McCarthy HO, Hirst DG, Robson T (July 2008). "A novel FK506-like binding protein (FKBPL) interacts with the glucocorticoid receptor and regulates steroid receptor signalling". Endocrinology. 149 (11): 5724–34. doi:10.1210/en.2008-0168. PMID 18669603. S2CID 32563192.

[pmid20103631-10] McKeen HD, Byrne C, Jithesh PV, Donley C, Valentine A, Yakkundi A, O'Rourke M, Swanton C, McCarthy HO, Hirst DG, Robson T (February 2010). "FKBPL regulates estrogen receptor signaling and determines response to endocrine therapy". Cancer Res. 70 (3): 1090–100. doi:10.1158/0008-5472.CAN-09-2515. PMID 20103631.

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)