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FERM and PDZ domain containing 2

From Wikipedia, the free encyclopedia
FRMPD2
Identifiers
AliasesFRMPD2, PDZD5C, PDZK4, PDZK5C, FERM and PDZ domain containing 2
External IDsOMIM: 613323; MGI: 2685472; HomoloGene: 51854; GeneCards: FRMPD2; OMA:FRMPD2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001017929
NM_001018071
NM_001042512
NM_152428
NM_001318191

XM_017316244
XM_036158980
XM_036158982

RefSeq (protein)

NP_001018081
NP_001035977
NP_001305120

n/a

Location (UCSC)Chr 10: 48.15 – 48.27 MbChr 14: 33.19 – 33.3 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

FERM and PDZ domain containing 2 is a protein that in humans is encoded by the FRMPD2 gene. [5]

Function

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This gene encodes a peripheral membrane protein and is located in a region of chromosome 10q that contains a segmental duplication. This copy of the gene is full-length and is in the telomeric duplicated region. Two other more centromerically proximal copies of the gene are partial and may represent pseudogenes. This full-length gene appears to function in the establishment and maintenance of cell polarization. The protein is recruited to cell-cell junctions in an E-cadherin-dependent manner, and is selectively localized at the basolateral membrane in polarized epithelial cells. Alternative splicing results in multiple transcript variants.

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000170324Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000108841Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: FERM and PDZ domain containing 2". Retrieved 2017-09-05.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.