FAM81A

FAM81A
Identifiers
Aliases	FAM81A, family with sequence similarity 81 member A
External IDs	MGI: 1924136; HomoloGene: 17584; GeneCards: FAM81A; OMA:FAM81A - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	59,523,555 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	70,049,842 bp
RNA expression pattern
	Top expressed in
	Brodmann area 9; ; prefrontal cortex; ; cingulate gyrus; ; anterior cingulate cortex; ; middle temporal gyrus; ; right frontal lobe; ; primary visual cortex; ; Brodmann area 23; ; right uterine tube; ; rectum;
	Top expressed in
	Epithelium of choroid plexus; ; piriform cortex; ; temporal lobe; ; amygdala; ; primary motor cortex; ; Region I of hippocampus proper; ; fourth ventricle; ; choroid plexus of fourth ventricle; ; prefrontal cortex; ; visual cortex;
	More reference expression data
	n/a
Orthologs
	145773
	76886
	ENSG00000157470
	ENSMUSG00000032224
	Q8TBF8
	Q3UXZ6
	NM_152450
	NM_029784
	NP_689663
	NP_084060
	Wikidata
View/Edit Human	View/Edit Mouse

FAM81A is a protein that in humans is encoded by the FAM81A gene which is expressed in the postsynaptic density of the brain. It plays a pivotal role in forming postsynaptic protein agglomerations, essential for synaptic function in the brain.^[5]^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000157470 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000032224 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Dosemeci A, Loo HK, Toy D, Winters CA, Reese TS, Tao-Cheng JH (April 2019). "FAM81A protein, a novel component of the postsynaptic density in adult brain". Neuroscience Letters. 699: 122–126. doi:10.1016/j.neulet.2019.02.003. PMC 6443461. PMID 30735723.
^ Zhang Q, Sun S, Xie Q, Wang X, Qian J, Yao J, et al. (May 2022). "FAM81A identified as a stemness-related gene by screening DNA methylation sites based on machine learning-accessed stemness in pancreatic cancer". Epigenomics. 14 (10): 569–588. doi:10.2217/epi-2022-0098. PMID 35574683. S2CID 248813424.
^ Kaizuka T, Hirouchi T, Saneyoshi T, Shirafuji T, Collins MO, Grant SG, et al. (March 2024). Kim E (ed.). "FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation". PLOS Biology. 22 (3): e3002006. doi:10.1371/journal.pbio.3002006. PMC 10919877. PMID 38452102.

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000157470 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000032224 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Dosemeci A, Loo HK, Toy D, Winters CA, Reese TS, Tao-Cheng JH (April 2019). "FAM81A protein, a novel component of the postsynaptic density in adult brain". Neuroscience Letters. 699: 122–126. doi:10.1016/j.neulet.2019.02.003. PMC 6443461. PMID 30735723.

[6] Zhang Q, Sun S, Xie Q, Wang X, Qian J, Yao J, et al. (May 2022). "FAM81A identified as a stemness-related gene by screening DNA methylation sites based on machine learning-accessed stemness in pancreatic cancer". Epigenomics. 14 (10): 569–588. doi:10.2217/epi-2022-0098. PMID 35574683. S2CID 248813424.

[7] Kaizuka T, Hirouchi T, Saneyoshi T, Shirafuji T, Collins MO, Grant SG, et al. (March 2024). Kim E (ed.). "FAM81A is a postsynaptic protein that regulates the condensation of postsynaptic proteins via liquid-liquid phase separation". PLOS Biology. 22 (3): e3002006. doi:10.1371/journal.pbio.3002006. PMC 10919877. PMID 38452102.

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