FAM177A1

FAM177A1
Identifiers
Aliases	FAM177A1, C14orf24, family with sequence similarity 177 member A1
External IDs	HomoloGene: 27852; GeneCards: FAM177A1; OMA:FAM177A1 - orthologs
Gene location (Human)
Chr.	Chromosome 14 (human)
End	35,113,130 bp
RNA expression pattern
	Top expressed in
	Achilles tendon; ; myocardium of left ventricle; ; left testis; ; right testis; ; corpus callosum; ; C1 segment; ; mucosa of transverse colon; ; rectum; ; right lung; ; upper lobe of left lung;
	n/a
	More reference expression data
	n/a
Orthologs
	283635
	n/a
	ENSG00000151327
	n/a
	Q8N128
	n/a
	NM_173607; NM_001079519; NM_001289022
	n/a
	NP_001072987; NP_001275951; NP_775878
	n/a
	Wikidata
View/Edit Human

Family with sequence similarity 177 member A1 (FAM177A1) is a protein that in humans is encoded by the FAM177A1 gene, previously known as C14orf24.^[3] The other member of this family is FAM177B.

Function

FAM177A1 has been linked to immune system regulation^[4] and to neurogenesis.^[5]^[6]

Interactions

IntAct reports physical interactions between FAM117A1 and these other human proteins:^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000151327 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "FAM177A1 family with sequence similarity 177 member A1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-08-24.
^ Liao, Bo-Wei; Zhang, Hong-Yan; Du, Wen-Tian; Ran, Yong; Wang, Yan-Yi; Xu, Zhi-Sheng (2021-12-15). "FAM177A1 Inhibits IL-1β-Induced Signaling by Impairing TRAF6-Ubc13 Association". Journal of Immunology. 207 (12): 3090–3097. doi:10.4049/jimmunol.2100561. ISSN 1550-6606. PMID 34799425. S2CID 244428716.
^ Ko, Hae Young; Lee, Dong Soo; Kim, Soonhag (2009-08-08). "Noninvasive imaging of microRNA124a-mediated repression of the chromosome 14 ORF 24 gene during neurogenesis". The FEBS Journal. 276 (17): 4854–4865. doi:10.1111/j.1742-4658.2009.07185.x. ISSN 1742-4658. PMID 19663910. S2CID 205881038.
^ Alazami, Anas M.; Patel, Nisha; Shamseldin, Hanan E.; Anazi, Shamsa; Al-Dosari, Mohammed S.; Alzahrani, Fatema; Hijazi, Hadia; Alshammari, Muneera; Aldahmesh, Mohammed A.; Salih, Mustafa A.; Faqeih, Eissa; Alhashem, Amal; Bashiri, Fahad A.; Al-Owain, Mohammed; Kentab, Amal Y. (2015-01-13). "Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families". Cell Reports. 10 (2): 148–161. doi:10.1016/j.celrep.2014.12.015. ISSN 2211-1247. PMID 25558065.
^ "IntAct Portal". www.ebi.ac.uk. Retrieved 2022-08-26.

External links

FAM177A1 Research Fund (for FAM177A1 Associated Disease)

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[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000151327 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] "FAM177A1 family with sequence similarity 177 member A1 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022-08-24.

[4] Liao, Bo-Wei; Zhang, Hong-Yan; Du, Wen-Tian; Ran, Yong; Wang, Yan-Yi; Xu, Zhi-Sheng (2021-12-15). "FAM177A1 Inhibits IL-1β-Induced Signaling by Impairing TRAF6-Ubc13 Association". Journal of Immunology. 207 (12): 3090–3097. doi:10.4049/jimmunol.2100561. ISSN 1550-6606. PMID 34799425. S2CID 244428716.

[5] Ko, Hae Young; Lee, Dong Soo; Kim, Soonhag (2009-08-08). "Noninvasive imaging of microRNA124a-mediated repression of the chromosome 14 ORF 24 gene during neurogenesis". The FEBS Journal. 276 (17): 4854–4865. doi:10.1111/j.1742-4658.2009.07185.x. ISSN 1742-4658. PMID 19663910. S2CID 205881038.

[6] Alazami, Anas M.; Patel, Nisha; Shamseldin, Hanan E.; Anazi, Shamsa; Al-Dosari, Mohammed S.; Alzahrani, Fatema; Hijazi, Hadia; Alshammari, Muneera; Aldahmesh, Mohammed A.; Salih, Mustafa A.; Faqeih, Eissa; Alhashem, Amal; Bashiri, Fahad A.; Al-Owain, Mohammed; Kentab, Amal Y. (2015-01-13). "Accelerating novel candidate gene discovery in neurogenetic disorders via whole-exome sequencing of prescreened multiplex consanguineous families". Cell Reports. 10 (2): 148–161. doi:10.1016/j.celrep.2014.12.015. ISSN 2211-1247. PMID 25558065.

[7] "IntAct Portal". www.ebi.ac.uk. Retrieved 2022-08-26.

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