Esterom
 | |
 Benzoylecgonine (top), the major component, and hydroxypropyl benzoylecgonine (bottom), the most active component | |
| Clinical data | |
|---|---|
| Trade names | Esterom |
| Identifiers | |
| DrugBank | |
Esterom is an investigational drug that was studied for use as a topical analgesic. Chemically, it is a mixture of compounds derived from the esterification of cocaine in propylene glycol.[1] While the major component is benzoylecgonine,[2] the analgesic activity is likely to due to hydroxypropyl benzoylecgonine, the only component that penetrates the skin.[1][3] Clinical trials of Esterom failed so show a statistically significant benefit for patients in 2002 and was never approved.[4][5]
References
[edit]- ^ a b McDonald S, Lunte C (November 2003). "Determination of the dermal penetration of esterom components using microdialysis sampling". Pharmaceutical Research. 20 (11): 1827–34. doi:10.1023/B:PHAM.0000003381.10208.8c. PMC 2519827. PMID 14661928.
- ^ Razak JL, Doyen HJ, Lunte CE (June 2003). "Cyclodextrin-modified micellar electrokinetic chromatography for the analysis of Esterom, a topical product consisting of hydrolyzed benzoylecgonine in propylene glycol". Electrophoresis. 24 (11): 1764–9. doi:10.1002/elps.200305374. PMC 2519819. PMID 12783453.
- ^ Hamaya H, Abdelrazek H, Strichartz GR (2002). Comparative potency for impulse-blockade and for cutaneous analgesia of traditional and novel local anesthetics. American Society of Anesthesiology Annual Meeting.
...hydroxypropylbenzoylecgonine (HPBE) is the only effective analgesic compound in [Esterom].
- ^ "Benzoylecgonine". go.drugbank.com. Retrieved 2025-03-08.
- ^ Baron, Michael (2002-09-09). "Entropin dives on disappointing drug". MarketWatch. Retrieved 2025-03-08.
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