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Esterom

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Esterom
Benzoylecgonine (top), the major component, and hydroxypropyl benzoylecgonine (bottom), the most active component
Clinical data
Trade namesEsterom
Identifiers
DrugBank

Esterom is an investigational drug being studied as a topical analgesic. Chemically, it is a mixture of compounds derived from the esterification of cocaine in propylene glycol.[1] While the major component is benzoylecgonine,[2] the analgesic activity is likely to due to hydroxypropyl benzoylecgonine, the only component that penetrates the skin.[1][3]

References

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  1. ^ a b McDonald S, Lunte C (November 2003). "Determination of the dermal penetration of esterom components using microdialysis sampling". Pharmaceutical Research. 20 (11): 1827–34. doi:10.1023/B:PHAM.0000003381.10208.8c. PMC 2519827. PMID 14661928.
  2. ^ Razak JL, Doyen HJ, Lunte CE (June 2003). "Cyclodextrin-modified micellar electrokinetic chromatography for the analysis of Esterom, a topical product consisting of hydrolyzed benzoylecgonine in propylene glycol". Electrophoresis. 24 (11): 1764–9. doi:10.1002/elps.200305374. PMC 2519819. PMID 12783453.
  3. ^ Hamaya H, Abdelrazek H, Strichartz GR (2002). Comparative potency for impulse-blockade and for cutaneous analgesia of traditional and novel local anesthetics. American Society of Anesthesiology Annual Meeting. ...hydroxypropylbenzoylecgonine (HPBE) is the only effective analgesic compound in [Esterom].