Endo-beta-n-acetylglucosaminidase

ENGASE
Identifiers
Aliases	ENGASE, endo-beta-N-acetylglucosaminidase
External IDs	OMIM: 611898; MGI: 2443788; HomoloGene: 13666; GeneCards: ENGASE; OMA:ENGASE - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	79,088,599 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	118,489,209 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; spleen; ; granulocyte; ; pancreatic ductal cell; ; tendon of biceps brachii; ; sural nerve; ; right lobe of thyroid gland; ; left ovary; ; right ovary; ; body of stomach;
	Top expressed in
	ankle; ; lip; ; yolk sac; ; neural layer of retina; ; thymus; ; duodenum; ; muscle of thigh; ; Paneth cell; ; stomach; ; bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	hydrolase activity; hydrolase activity, acting on glycosyl bonds; mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity;
Cellular component	cytoplasm; lysosome; cytosol;
Biological process	metabolism; protein folding; protein deglycosylation;
	Sources:Amigo / QuickGO
Orthologs
	64772
	217364
	ENSG00000167280
	ENSMUSG00000033857
	Q8NFI3
	Q8BX80
NM_001042573; NM_022759; NM_001396052; NM_001396053; NM_001396054;
	NM_001396055
	NM_172573; NM_001359368
	NP_001036038
NP_766161; NP_001346297; NP_001390767; NP_001390768; NP_001390769;
	NP_001390770
	Wikidata
View/Edit Human	View/Edit Mouse

Endo-beta-N-acetylglucosaminidase is a protein that in humans is encoded by the ENGASE gene. ^[5]

Function

This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000167280 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000033857 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Endo-beta-N-acetylglucosaminidase". Retrieved 2018-08-24.

Suzuki T, Yano K, Sugimoto S, Kitajima K, Lennarz WJ, Inoue S, Inoue Y, Emori Y (July 2002). "Endo-beta-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol". Proc. Natl. Acad. Sci. U.S.A. 99 (15): 9691–6. Bibcode:2002PNAS...99.9691S. doi:10.1073/pnas.152333599. PMC 124980. PMID 12114544.
Ortutay Z, Polgár A, Gömör B, Géher P, Lakatos T, Glant TT, Gay RE, Gay S, Pállinger E, Farkas C, Farkas E, Tóthfalusi L, Kocsis K, Falus A, Buzás EI (August 2003). "Synovial fluid exoglycosidases are predictors of rheumatoid arthritis and are effective in cartilage glycosaminoglycan depletion". Arthritis Rheum. 48 (8): 2163–72. doi:10.1002/art.11093. PMID 12905469.
Butkinaree C, Cheung WD, Park S, Park K, Barber M, Hart GW (August 2008). "Characterization of beta-N-acetylglucosaminidase cleavage by caspase-3 during apoptosis". J. Biol. Chem. 283 (35): 23557–66. doi:10.1074/jbc.M804116200. PMC 2527095. PMID 18586680.
Dorfmueller HC, van Aalten DM (February 2010). "Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds". FEBS Lett. 584 (4): 694–700. doi:10.1016/j.febslet.2009.12.020. PMC 2828546. PMID 20026047.
Park K, Saudek CD, Hart GW (July 2010). "Increased expression of beta-N-acetylglucosaminidase in erythrocytes from individuals with pre-diabetes and diabetes". Diabetes. 59 (7): 1845–50. doi:10.2337/db09-1086. PMC 2889787. PMID 20413512.
Chantret I, Fasseu M, Zaoui K, Le Bizec C, Sadou Yayé H, Dupré T, Moore SE (July 2010). "Identification of roles for peptide: N-glycanase and endo-beta-N-acetylglucosaminidase (Engase1p) during protein N-glycosylation in human HepG2 cells". PLOS ONE. 5 (7): e11734. Bibcode:2010PLoSO...511734C. doi:10.1371/journal.pone.0011734. PMC 2909182. PMID 20668520.
Xiao F, Zheng X, Cui M, Shi G, Chen X, Li R, Song Z, Rudolph KL, Chen B, Ju Z (October 2011). "Telomere dysfunction-related serological markers are associated with type 2 diabetes". Diabetes Care. 34 (10): 2273–8. doi:10.2337/dc10-2431. PMC 3177723. PMID 21873561.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000167280 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000033857 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Endo-beta-N-acetylglucosaminidase". Retrieved 2018-08-24.

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Function

References

Further reading