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Elizabeth Sattely

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Elizabeth S. Sattely is an American scientist and biotechnology engineer. She is an Associate Professor of Chemical Engineering [1] in the Department of Chemical Engineering, an HHMI investigator,[1] and a ChEM-H Faculty Fellow[2] at Stanford University.

Education

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Dr. Sattely completed her graduate training at Boston College in organic chemistry with Amir Hoveyda and her postdoctoral studies in biochemistry at Harvard Medical School with Christopher T. Walsh, where she worked on natural product biosynthesis in bacteria.[3]

Research

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Inspired by human reliance on plants and plant-derived molecules for food and medicine, the Sattely laboratory is focused on the discovery and engineering of plant metabolic pathways to make molecules that can enhance human health.[4][5] These engineering targets include:

Beyond fundamental research into biosynthesis of molecules important for human health, the Sattely lab also works on metabolites important for plant health, both in the realm of nutrient acquisition and defense response. Research is not only dedicated to molecules within the plant itself, but also to molecules involved in plant-microbe interactions. Examples are:

Another part of the laboratory involves the study of plant-derived value added small molecules, such as:

Awards

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Work in the Sattely lab has been recognized by an NIH New Innovator Award, a DOE Early Career Award, an HHMI-Simons Faculty Scholar Award, a DARPA Young Investigator Award, and a AAAS Mason Award for Women in the Chemical Sciences.[15]

Personal life

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Elizabeth Sattely is married to Dr. Michael Fischbach, associate professor of bioengineering at Stanford University. Her favorite bacterium is Azospirillum brasilense.[16]

Publications

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  • Discovery and engineering of plant chemistry, 2017

References

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  1. ^ "Elizabeth Sattely, PhD". HHMI.org. Retrieved 2018-11-05.
  2. ^ "Elizabeth Sattely | Sattely Research Group". web.stanford.edu. Retrieved 2018-11-05.
  3. ^ Sattely, Elizabeth S.; Meek, Simon J.; Malcolmson, Steven J.; Schrock, Richard R.; Hoveyda, Amir H. (2009-01-28). "Design and stereoselective preparation of a new class of chiral olefin metathesis catalysts and application to enantioselective synthesis of quebrachamine: catalyst development inspired by natural product synthesis". Journal of the American Chemical Society. 131 (3): 943–953. doi:10.1021/ja8084934. ISSN 1520-5126. PMC 2819342. PMID 19113867.
  4. ^ Anarat-Cappillino, Gülbenk; Sattely, Elizabeth S (January 2014). "The chemical logic of plant natural product biosynthesis". Current Opinion in Plant Biology. 19: 51–58. doi:10.1016/j.pbi.2014.03.007. ISSN 1369-5266. PMC 6863165. PMID 24727074.
  5. ^ Lau, Warren; Fischbach, Michael A.; Osbourn, Anne; Sattely, Elizabeth S. (2014-06-10). "Key Applications of Plant Metabolic Engineering". PLOS Biology. 12 (6): e1001879. doi:10.1371/journal.pbio.1001879. ISSN 1545-7885. PMC 4051588. PMID 24915445.
  6. ^ Klein, Andrew P.; Anarat-Cappillino, Gülbenk; Sattely, Elizabeth S. (2013-10-21). "Minimum Set of Cytochromes P450 for Reconstituting the Biosynthesis of Camalexin, a MajorArabidopsisAntibiotic". Angewandte Chemie International Edition. 52 (51): 13625–13628. doi:10.1002/anie.201307454. ISSN 1433-7851. PMC 3867539. PMID 24151049.
  7. ^ Klein, Andrew P; Sattely, Elizabeth S (2015-09-21). "Two cytochromes P450 catalyze S-heterocyclizations in cabbage phytoalexin biosynthesis". Nature Chemical Biology. 11 (11): 837–839. doi:10.1038/nchembio.1914. ISSN 1552-4450. PMC 4731101. PMID 26389737.
  8. ^ Klein, Andrew P.; Sattely, Elizabeth S. (2017-02-21). "Biosynthesis of cabbage phytoalexins from indole glucosinolate". Proceedings of the National Academy of Sciences. 114 (8): 1910–1915. doi:10.1073/pnas.1615625114. ISSN 0027-8424. PMC 5338394. PMID 28154137.
  9. ^ Lau, Warren; Sattely, Elizabeth S. (2015-09-10). "Six enzymes from mayapple that complete the biosynthetic pathway to the etoposide aglycone". Science. 349 (6253): 1224–1228. Bibcode:2015Sci...349.1224L. doi:10.1126/science.aac7202. ISSN 0036-8075. PMC 6861171. PMID 26359402.
  10. ^ Rajniak, Jakub; Giehl, Ricardo F. H.; Chang, Evelyn; Murgia, Irene; von Wirén, Nicolaus; Sattely, Elizabeth S. (2018-03-26). "Biosynthesis of redox-active metabolites in response to iron deficiency in plants". Nature Chemical Biology. 14 (5): 442–450. doi:10.1038/s41589-018-0019-2. ISSN 1552-4450. PMC 6693505. PMID 29581584.
  11. ^ Chen, Yun Chu; Holmes, Eric; Rajniak, Jakub; Kim, Jung-Gun; Tang, Sandy; Fischer, Curt; Mudgett, Mary Beth; Sattely, Elizabeth (2018-03-25). "N-hydroxy-pipecolic acid is a mobile signal that induces systemic disease resistance in Arabidopsis". bioRxiv: 288449. doi:10.1101/288449.
  12. ^ "Group Members | Sattely Research Group". web.stanford.edu. Retrieved 2018-11-05.
  13. ^ LeFevre, Gregory H.; Portmann, Andrea C.; Müller, Claudia E.; Sattely, Elizabeth S.; Luthy, Richard G. (2016-01-08). "Plant Assimilation Kinetics and Metabolism of 2-Mercaptobenzothiazole Tire Rubber Vulcanizers by Arabidopsis". Environmental Science & Technology. 50 (13): 6762–6771. Bibcode:2016EnST...50.6762L. doi:10.1021/acs.est.5b04716. ISSN 0013-936X. PMID 26698834.
  14. ^ "Group Members | Sattely Research Group". web.stanford.edu. Retrieved 2018-11-05.
  15. ^ "Elizabeth Sattely | Sattely Research Group". web.stanford.edu. Retrieved 2018-11-05.
  16. ^ Introduction to Dr. Sattely's talk at the Center for Molecular Analysis and Design, 2018 Symposium
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