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Elizabeth A. Spencer

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Elizabeth A. Spencer is a British epidemiologist and researcher at the Centre for Evidence-Based Medicine (CEBM), University of Oxford, whose research focuses on systematic reviews, multimorbidity, and evidence synthesis.[1]

Career

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Spencer’s research spans areas of public health including living reviews, biomarkers, self-care in chronic conditions, and the impact of environmental exposures on health.[2] She has advanced strategies for managing multimorbidity.[3][4][5][6] She has also enhanced methodologies in evidence synthesis, emphasising well-defined research questions, transparent methodologies, and comprehensive search strategies.[7]

At the Centre for Evidence-Based Medicine (CEBM),[8] Spencer is a major contributor to the Evidence-Based Multimorbidity Project. This initiative focuses on developing strategies for the early recognition, screening, and treatment of multimorbidity, aiming to reduce the burden of chronic conditions.[9][10]

She has been involved in studies at CEBM including "Tamiflu as a Treatment for Influenza," evaluating its efficacy in combating influenza[11] and "Primodos and Congenital Malformations," which investigated the potential links between the hormonal pregnancy test and birth defects.[12] In addition, she has contributed to "Green Tea and Blood Pressure Effects," which examined the potential benefits of green tea consumption on blood pressure[13] and "Transmission of SARS-CoV-2," a study that focused on understanding the transmission dynamics of the virus, particularly among asymptomatic and pre-symptomatic individuals.[14]

Spencer was also involved in the launch of Open Evidence Reviews, an initiative by CEBM providing real-time updates on evidence related to COVID-19. This initiative addressed critical areas such as transmission dynamics, the effectiveness of public health interventions, and the role of PCR cycle thresholds in predicting infectiousness.[15] Her additional research suggests that PCR cycle threshold values may be crucial in predicting the infectiousness of asymptomatic or pre-symptomatic individuals with COVID-19. This study, part of a comprehensive review, highlights the importance of PCR testing in understanding transmission dynamics.[16]

She has researched the risks of hormone replacement therapy (HRT) using large-scale databases. She has also contributed to the Million Women Study, a landmark research project investigating the health of women aged 50 and over, with a focus on evaluating the risks and benefits of HRT and other health factors.[17][18][19][20]

Selected publications

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  • Davey, G. K.; Spencer, E. A.; Appleby, P. N.; Allen, N. E.; Knox, K. H.; Key, T. J. "EPIC-Oxford: Lifestyle characteristics and nutrient intakes in a cohort of 33,883 meat-eaters and 31,546 non-meat-eaters in the UK." Public Health Nutrition. 2003 May; 6(3): 259–269. doi:10.1079/PHN2002430. PMID 12740075.
  • Rosca, E. C.; Heneghan, C.; Spencer, E. A.; Brassey, J.; Plüddemann, A.; Onakpoya, I. J.; Evans, D.; Conly, J. M.; Jefferson, T. "Transmission of SARS-CoV-2 associated with cruise ship travel: A systematic review." Tropical Medicine and Infectious Disease. 2022 Oct 9; 7 (10): 290. doi:10.3390/tropicalmed7100290. PMID 36288031; PMCID: PMC9610645.
  • Rosca, E. C.; Heneghan, C.; Spencer, E. A.; Plüddemann, A.; Maltoni, S.; Gandini, S.; Onakpoya, I. J.; Evans, D.; Conly, J. M.; Jefferson, T. "Coinfection with Strongyloides and SARS-CoV-2: A systematic review." Tropical Medicine and Infectious Disease. 2023 Apr 25; 8(5):248. doi:10.3390/tropicalmed8050248. PMID 37235296; PMCID: PMC10224069.

References

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  1. ^ "Elizabeth Spencer". www.cebm.ox.ac.uk. Retrieved 2025-01-06.
  2. ^ "Elizabeth Spencer". www.cebm.ox.ac.uk. Retrieved 2025-01-06.
  3. ^ "Evidence-based multimorbidity". www.cebm.ox.ac.uk. Retrieved 2025-01-06.
  4. ^ Spencer, E. A.; Ford, G. A.; Chan, M. S.; Perera, R.; Heneghan, C. J. (2020-11-27), Biomarkers in the prediction of multimorbidity: scoping review, doi:10.1101/2020.11.25.20214999, retrieved 2025-01-06
  5. ^ "Elizabeth Spencer". www.cebm.ox.ac.uk. Retrieved 2025-01-06.
  6. ^ Suls, Jerry; Bayliss, Elizabeth A.; Berry, Jay; Bierman, Arlene S.; Chrischilles, Elizabeth A.; Farhat, Tilda; Fortin, Martin; Koroukian, Siran M.; Quinones, Ana; Silber, Jeffrey H.; Ward, Brian W.; Wei, Melissa; Young-Hyman, Deborah; Klabunde, Carrie N. (August 2021). "Measuring Multimorbidity: Selecting the Right Instrument for the Purpose and the Data Source". Medical Care. 59 (8): 743–756. doi:10.1097/MLR.0000000000001566. ISSN 0025-7079. PMC 8263466. PMID 33974576.
  7. ^ "Five things to consider before you do a systematic review". www.cebm.ox.ac.uk. Retrieved 2025-01-06.
  8. ^ "Home". www.cebm.ox.ac.uk. Retrieved 2025-01-06.
  9. ^ "Evidence-based multimorbidity". www.cebm.ox.ac.uk. Retrieved 2025-01-06.
  10. ^ "Research projects". www.cebm.ox.ac.uk. Retrieved 2025-01-06.
  11. ^ "Tamiflu as a treatment for influenza". www.cebm.ox.ac.uk. Retrieved 2025-01-07.
  12. ^ "The Primodos story". www.cebm.ox.ac.uk. Retrieved 2025-01-06.
  13. ^ "Green tea and blood pressure effects". www.cebm.ox.ac.uk. Retrieved 2025-01-06.
  14. ^ "Transmission of SARS-CoV-2". www.cebm.ox.ac.uk. Retrieved 2025-01-06.
  15. ^ "CEBM launches Open Evidence Reviews". Retrieved 2025-01-06.
  16. ^ "PCR cycle threshold may be key to predicting infectiousness of people with asymptomatic and pre-symptomatic COVID-19, suggests new review". Retrieved 2025-01-06.
  17. ^ "Evidence in Women's Health: Menopause and Hormone Replacement Therapy (HRT) - What are the risks, benefits and experiences for women?". podcasts.ox.ac.uk. Retrieved 2025-01-06.
  18. ^ Roddam, Andrew W.; Spencer, Elizabeth; Banks, Emily; Beral, Valerie; Reeves, Gillian; Appleby, Paul; Barnes, Isobel; Whiteman, David C.; Keyal, Timothy J. (April 2005). "Reproducibility of a short semi-quantitative food group questionnaire and its performance in estimating nutrient intake compared with a 7-day diet diary in the Million Women Study". Public Health Nutrition. 8 (2): 201–213. doi:10.1079/PHN2004676. ISSN 1475-2727. PMID 15877913.
  19. ^ Reeves, Gillian K.; Pirie, Kirstin; Beral, Valerie; Green, Jane; Spencer, Elizabeth; Bull, Diana; Million Women Study Collaboration (2007-12-01). "Cancer incidence and mortality in relation to body mass index in the Million Women Study: cohort study". BMJ (Clinical Research Ed.). 335 (7630): 1134. doi:10.1136/bmj.39367.495995.AE. ISSN 1756-1833. PMC 2099519. PMID 17986716.
  20. ^ Liu, Bette; Balkwill, Angela; Spencer, Elizabeth; Beral, Valerie; Million Women Study Collaborators (June 2008). "Relationship between body mass index and length of hospital stay for gallbladder disease". Journal of Public Health (Oxford, England). 30 (2): 161–166. doi:10.1093/pubmed/fdn011. ISSN 1741-3850. PMID 18308742. {{cite journal}}: |last5= has generic name (help)
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