Eggerthella lenta
| Eggerthella lenta | |
|---|---|
Scientific classification 
| |
| Domain: | Bacteria |
| Phylum: | Actinomycetota |
| Class: | Coriobacteriia |
| Order: | Eggerthellales |
| Family: | Eggerthellaceae |
| Genus: | Eggerthella |
| Species: | E. lenta
|
| Binomial name | |
| Eggerthella lenta Eggerth, 1935[1]
| |
Eggerthella lenta is a Gram-positive, anaerobic species of bacteria which comprises part of the human microbiome. It has been found in the human gastrointestinal tract, female reproductive system and male prostate.[2] Occasionally it can cause disease by spreading to other areas, including bloodstream infections, liver abscesses, bacterial vaginosis and meningitis.[2]
During a pre clinical model, Eggerthella lenta was found to reduce amino acids such as arginine, citrulline and tryptophan metabolites to levels found in older persons and can trigger autoimmune responses before the onset of the clinical symptoms of rheumatoid arthritis in which the immune system produces autoantibodies that mistakenly target and attack the body's tissues and cells instead of invading viruses or bacteria.[3][4][5]
E. lenta levels are enriched in inflammatory bowel disease, and the bacterium has been shown to activate T helper 17 cells. It has been shown to worsen colitis in mice models.[6] E. lenta has been found to be present in higher levels in the gut of people with Graves' disease.[7]
E. lenta has been shown to inactivate the cardiac drug digoxin.[8]
The species was known until 1999 as Eubacterium lentum.[9]
References
[edit]- ^ Eggerth, Arnold H. (September 1935). "The Gram-positive Non-spore-bearing Anaerobic Bacilli of Human Feces". Journal of Bacteriology. 30 (3): 277–299. doi:10.1128/jb.30.3.277-299.1935. ISSN 0021-9193. PMC 543656. PMID 16559837.
- ^ a b Jiang, Shuming; E, Jianfei; Wang, Dengchao; Zou, Yanjiao; Liu, Xiao; Xiao, Hualiang; Wen, Yuan; Chen, Zongyao (2021-09-20). "Eggerthella lenta bacteremia successfully treated with ceftizoxime: case report and review of the literature". European Journal of Medical Research. 26 (1): 111. doi:10.1186/s40001-021-00582-y. ISSN 2047-783X. PMC 8454090. PMID 34544476.
- ^ Gallagher, Colette (18 September 2023). "Mayo Clinic researchers identify link between gut bacteria and pre-clinical autoimmunity and aging in rheumatoid arthritis". Mayo Clinic website. Archived from the original on 21 November 2023. Retrieved 21 November 2023.
- ^ Balakrishnan, Baskar; Luckey, David; Wright, Kerry; Davis, John M; Chen, Jun; Taneja, Veena (9 September 2023). "Eggerthella lenta augments preclinical autoantibody production and metabolic shift mimicking senescence in arthritis". National Institutes of Health National Library of Medicine (nih.gov). Vol. 9, no. 35. pp. eadg1129. doi:10.1126/sciadv.adg1129. PMID 37656793. Archived from the original on 21 November 2023. Retrieved 21 November 2023.
- ^ Balakrishnan, Baskar; Luckey, David; Wright, Kerry; Davis, John M; Chen, Jun; Taneja, Veena (1 September 2023). "Eggerthella lenta augments preclinical autoantibody production and metabolic shift mimicking senescence in arthritis". Science Advances. 9 (35). doi:10.1126/sciadv.adg1129. PMC 10854426.
- ^ Alexander, Margaret; Ang, Qi Yan; Nayak, Renuka R.; Bustion, Annamarie E.; Sandy, Moriah; Zhang, Bing; Upadhyay, Vaibhav; Pollard, Katherine S.; Lynch, Susan V.; Turnbaugh, Peter J. (2022-01-12). "Human gut bacterial metabolism drives Th17 activation and colitis". Cell Host & Microbe. 30 (1): 17–30.e9. doi:10.1016/j.chom.2021.11.001. ISSN 1931-3128. PMC 8785648. PMID 34822777.
- ^ Zhu, Qiyun; Hou, Qiangchuan; Huang, Shi; Ou, Qianying; Huo, Dongxue; Vázquez-Baeza, Yoshiki; Cen, Chaoping; Cantu, Victor; Estaki, Mehrbod; Chang, Haibo; Belda-Ferre, Pedro (November 2021). "Compositional and genetic alterations in Graves' disease gut microbiome reveal specific diagnostic biomarkers". The ISME Journal. 15 (11): 3399–3411. doi:10.1038/s41396-021-01016-7. PMC 8528855. PMID 34079079.
- ^ Haiser, Henry J.; Gootenberg, David B.; Chatman, Kelly; Sirasani, Gopal; Balskus, Emily P.; Turnbaugh, Peter J. (2013-07-19). "Predicting and manipulating cardiac drug inactivation by the human gut bacterium Eggerthella lenta". Science. 341 (6143): 295–298. Bibcode:2013Sci...341..295H. doi:10.1126/science.1235872. PMC 3736355. PMID 23869020.
- ^ Kageyama, A.; Benno, Y.; Nakase, T. (October 1999). "Phylogenetic evidence for the transfer of Eubacterium lentum to the genus Eggerthella as Eggerthella lenta gen. nov., comb. nov". International Journal of Systematic Bacteriology. 49 (4): 1725–1732. doi:10.1099/00207713-49-4-1725. ISSN 0020-7713. PMID 10555354.
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