E2F5

E2F5
Identifiers
Aliases	E2F5, E2F-5, E2F transcription factor 5
External IDs	OMIM: 600967; MGI: 105091; HomoloGene: 1472; GeneCards: E2F5; OMA:E2F5 - orthologs
Gene location (Human) Chr. Chromosome 8 (human) Band 8q21.2 Start 85,177,154 bp End 85,217,158 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 A1 Start 14,643,701 bp End 14,671,369 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone ganglionic eminence lymph node islet of Langerhans testicle rectum appendix granulocyte tibial nerve right uterine tube Top expressed in zygote secondary oocyte primary oocyte somite epiblast abdominal wall primitive streak medial ganglionic eminence tail of embryo submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA binding transcription factor binding protein binding protein dimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific sequence-specific DNA binding Cellular component cytoplasm nucleolus nucleus transcription regulator complex nucleoplasm fibrillar center RNA polymerase II transcription regulator complex Biological process animal organ morphogenesis regulation of cell cycle cell projection organization regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II transcription, DNA-templated negative regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1875 13559 Ensembl ENSG00000133740 ENSMUSG00000027552 UniProt Q15329 Q61502 RefSeq (mRNA) NM_001083588 NM_001083589 NM_001951 NM_007892 RefSeq (protein) NP_001077057 NP_001077058 NP_001942 NP_031918 Location (UCSC) Chr 8: 85.18 – 85.22 Mb Chr 3: 14.64 – 14.67 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Transcription factor E2F5 is a protein that in humans is encoded by the E2F5 gene.

Function

The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionarily conserved domains that are present in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein is differentially phosphorylated and is expressed in a wide variety of human tissues. It has higher identity to E2F4 than to other family members. Both this protein and E2F4 interact with tumor suppressor proteins p130 and p107, but not with pRB. Alternative splicing results in multiple variants encoding different isoforms.

Interactions

E2F5 has been shown to interact with TFDP1.

See also

• E2F

Further reading

• Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R (Jun 1995). "E2F-5, a new E2F family member that interacts with p130 in vivo". Molecular and Cellular Biology. 15 (6): 3082–9. doi:10.1128/mcb.15.6.3082. PMC 230539. PMID 7760804.
• Ginsberg D, Vairo G, Chittenden T, Xiao ZX, Xu G, Wydner KL, DeCaprio JA, Lawrence JB, Livingston DM (Nov 1994). "E2F-4, a new member of the E2F transcription factor family, interacts with p107". Genes & Development. 8 (22): 2665–79. doi:10.1101/gad.8.22.2665. PMID 7958924.
• Beijersbergen RL, Kerkhoven RM, Zhu L, Carlée L, Voorhoeve PM, Bernards R (Nov 1994). "E2F-4, a new member of the E2F gene family, has oncogenic activity and associates with p107 in vivo". Genes & Development. 8 (22): 2680–90. doi:10.1101/gad.8.22.2680. PMID 7958925.
• Itoh A, Levinson SF, Morita T, Kourembanas S, Brody JS, Mitsialis SA (1996). "Structural characterization and specificity of expression of E2F-5: a new member of the E2F family of transcription factors". Cellular & Molecular Biology Research. 41 (3): 147–54. PMID 8589754.
• Lindeman GJ, Gaubatz S, Livingston DM, Ginsberg D (May 1997). "The subcellular localization of E2F-4 is cell-cycle dependent". Proceedings of the National Academy of Sciences of the United States of America. 94 (10): 5095–100. Bibcode:1997PNAS...94.5095L. doi:10.1073/pnas.94.10.5095. PMC 24637. PMID 9144196.
• Vaishnav YN, Vaishnav MY, Pant V (Jan 1998). "The molecular and functional characterization of E2F-5 transcription factor". Biochemical and Biophysical Research Communications. 242 (3): 586–92. doi:10.1006/bbrc.1997.8010. PMID 9464260.
• Morris L, Allen KE, La Thangue NB (Apr 2000). "Regulation of E2F transcription by cyclin E-Cdk2 kinase mediated through p300/CBP co-activators". Nature Cell Biology. 2 (4): 232–9. doi:10.1038/35008660. PMID 10783242. S2CID 36134762.
• Gaubatz S, Lindeman GJ, Ishida S, Jakoi L, Nevins JR, Livingston DM, Rempel RE (Sep 2000). "E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control". Molecular Cell. 6 (3): 729–35. doi:10.1016/S1097-2765(00)00071-X. PMID 11030352.
• D'Souza SJ, Pajak A, Balazsi K, Dagnino L (Jun 2001). "Ca2+ and BMP-6 signaling regulate E2F during epidermal keratinocyte differentiation". The Journal of Biological Chemistry. 276 (26): 23531–8. doi:10.1074/jbc.M100780200. PMID 11319226.
• Chestukhin A, Litovchick L, Rudich K, DeCaprio JA (Jan 2002). "Nucleocytoplasmic shuttling of p130/RBL2: novel regulatory mechanism". Molecular and Cellular Biology. 22 (2): 453–68. doi:10.1128/MCB.22.2.453-468.2002. PMC 139733. PMID 11756542.
• Apostolova MD, Ivanova IA, Dagnino C, D'Souza SJ, Dagnino L (Sep 2002). "Active nuclear import and export pathways regulate E2F-5 subcellular localization". The Journal of Biological Chemistry. 277 (37): 34471–9. doi:10.1074/jbc.M205827200. PMID 12089160.
• Chen CR, Kang Y, Siegel PM, Massagué J (Jul 2002). "E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression". Cell. 110 (1): 19–32. doi:10.1016/S0092-8674(02)00801-2. PMID 12150994. S2CID 8945574.
• Macaluso M, Cinti C, Russo G, Russo A, Giordano A (Jun 2003). "pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer". Oncogene. 22 (23): 3511–7. doi:10.1038/sj.onc.1206578. PMID 12789259.
• Ohtani N, Brennan P, Gaubatz S, Sanij E, Hertzog P, Wolvetang E, Ghysdael J, Rowe M, Hara E (Jul 2003). "Epstein-Barr virus LMP1 blocks p16INK4a-RB pathway by promoting nuclear export of E2F4/5". The Journal of Cell Biology. 162 (2): 173–83. doi:10.1083/jcb.200302085. PMC 2172795. PMID 12860972.
• Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (Jun 2004). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nature Biotechnology. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
• Jiang Y, Saavedra HI, Holloway MP, Leone G, Altura RA (Sep 2004). "Aberrant regulation of survivin by the RB/E2F family of proteins". The Journal of Biological Chemistry. 279 (39): 40511–20. doi:10.1074/jbc.M404496200. PMID 15271987.
• Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S (Sep 2004). "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research. 14 (9): 1711–8. doi:10.1101/gr.2435604. PMC 515316. PMID 15342556.
• Joshi B, Ordonez-Ercan D, Dasgupta P, Chellappan S (Mar 2005). "Induction of human metallothionein 1G promoter by VEGF and heavy metals: differential involvement of E2F and metal transcription factors". Oncogene. 24 (13): 2204–17. doi:10.1038/sj.onc.1208206. PMID 15735762.
• Swetloff A, Ferretti P (2006). "Changes in E2F5 intracellular localization in mouse and human choroid plexus epithelium with development". The International Journal of Developmental Biology. 49 (7): 859–65. doi:10.1387/ijdb.051996as. PMID 16172982.

External links

• E2F5+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.