Draft:Xinyuan Fu

Xin-Yuan Fu

Introduction Dr. Xin-Yuan Fu is a prominent molecular biologist, biochemist, and entrepreneur. He is currently a Chair Professor at West China Hospital, Chengdu, and the Founder and Chief Scientific Officer (CSO) of GenEros BioPharma in Hangzhou, China. Dr. Fu is internationally recognized for his discovery of the JAK-STAT signaling pathway, which has significantly advanced the understanding of cellular signaling and its therapeutic applications. Early Life and Education Dr. Fu was born in China and completed his undergraduate studies under the mentorship of renowned geneticist Tan Jiazhen at Fudan University. He participated in the inaugural China-US Molecular Biology Exchange Program (CUSMBEA) and received his Ph.D. in Molecular Biology from Columbia University in 1988, under the guidance of Dr. James Manley. He subsequently conducted postdoctoral research at Rockefeller University (1988-1991) with Dr. James Darnell, where he made foundational discoveries about the STAT gene family and the JAK-STAT signaling pathway. Academic and Professional Career • United States (1992-2015) Dr. Fu began his academic career as an Assistant Professor at Mount Sinai School of Medicine, New York (1992-1994). He later joined Yale University, where he served as an Associate Professor in the Department of Pathology and Immunobiology (1994-2003) and chaired the M.D./Ph.D. Committee. From 2004 to 2015, he was a Professor of Immunology at Indiana University, contributing to cancer and inflammatory disease research. • China and Singapore (2000-Present) Dr. Fu returned to China in 2000 as the founding director of the Tsinghua Institute of Genome Research, where he led groundbreaking genetic research until 2006. From 2008 to 2018, he held roles at the National University of Singapore, including Head of the Department of Biochemistry and Principal Scientist at the Cancer Science Institute. Since 2017, he has been a Chair Professor at Sichuan University’s West China Hospital, where he directs the Laboratory of Human Diseases and Immunotherapy. Research Contributions Dr. Fu is widely recognized for his discovery of the JAK-STAT signaling pathway, a key cellular signaling mechanism involved in immunity, development, and cancer. This discovery was named one of the Top 10 Scientific Achievements of 1993 by Science magazine. The pathway has since been the subject of over 40,000 research publications and is the basis for multiple FDA-approved drugs treating inflammatory diseases, autoimmune disorders, and cancers.

His laboratory has also elucidated STAT’s roles in inflammation, cancer, cardiovascular disease, and neurodegeneration. Notably, Dr. Fu’s work has contributed to the understanding of Th-GM T helper cells as pivotal regulators of autoimmune diseases. Entrepreneurial Work In 2015, Dr. Fu founded GenEros BioPharma, a leading biotech company specializing in innovative therapeutics for inflammatory diseases and cancer. The company’s flagship therapies, based on novel insights into the JAK-STAT pathway and Th-GM mechanisms, have entered global clinical trials, including FDA-approved studies for rheumatoid arthritis and COVID-19.

GenEros BioPharma operates research and development centers in Hangzhou, Shanghai, Chengdu, and Delaware, USA, with plans for an IPO in the United States within the next two years. Awards and Honors • Member, Hematology-1/Hematopoiesis Study Section, NIH, USA (1999-2004) • Career Development Award, NIH (1996-2002) • Fellowship, Cancer Research Institute, New York (1987-1990) • CUSMBEA First-Class Fellow (1981)

Selected Publications 1. Fu, X.-Y. A transcription factor with SH2 and SH3 domains is directly activated by an interferon-alpha-induced cytoplasmic protein tyrosine kinase(s). Cell, 70:323-335 (1992).

2. Chin, E.Y., Kitagawa, M., et al. Cell Growth Arrest and Induction of Cyclin Dependent Kinase Inhibitor p21WAF1/CIP1 Mediated by STAT1. Science, 272:719-722 (1996).

3. Sheng, W., Yang, F., et al. A distinct subset of T helper cells regulated by STAT5 is crucial for autoimmune neuroinflammation. Cell Research, 24(12):1387-402 (2014).