Draft:Tmax (pharmacology)

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Last edited by Detroit Stahl (talk | contribs) 3 months ago. (Update)

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T_max is the time it takes for a pharmaceutical to attain maximum plasma concentration or the time to (C_max) after it is administered. T_max is a function of the rate of drug absorption and the rate of drug elimination. At T_max, the rate of drug absorption is equal to the rate of drug elimination.

Description

T_max is a measure of the rate of availability, of how quickly it takes for a pharmaceutical to exert it's therapeutic action. C_max is the opposite of C_min, which is the minimum (or trough) concentration that a drug achieves after dosing. The related pharmacokinetic parameter t_max is the time at which the C_max is observed.^[1]

The value for tmax is affected by many of the same drug and patient characteristics that determine the Cmax value, including administration route and formulation, as well as the relative rates of absorption, distribution and clearance. It might be expected that weak acids, which are absorbed rapidly and extensively from the stomach, may show tmax values shorter, on average, than do weak bases.

Drugs of abuse often have a short tmax, since a short time between administration and drug effect is more reinforcing of behaviour.

After an intravenous administration, C_max and t_max are closely dependent on the experimental protocol, since the concentrations are always decreasing after the dose. But after oral administration, C_max and t_max are dependent on the extent, and the rate of drug absorption and the disposition profile of the drug. They could be used to characterize the properties of different formulations in the same subject.^[2]

References

^ Amy Newlands. "Statistics and Pharmacokinetics in Clinical Pharmacology Studies" (PDF). Archived from the original (PDF) on 2013-11-13.
^ Urso R, Blardi P, Giorgi G (March 2002). "A short introduction to pharmacokinetics". Eur Rev Med Pharmacol Sci. 6 (2–3): 33–44. PMID 12708608.

[1] Amy Newlands. "Statistics and Pharmacokinetics in Clinical Pharmacology Studies" (PDF). Archived from the original (PDF) on 2013-11-13.

[pmid12708608-2] Urso R, Blardi P, Giorgi G (March 2002). "A short introduction to pharmacokinetics". Eur Rev Med Pharmacol Sci. 6 (2–3): 33–44. PMID 12708608.

[1]

[2]

Description

See also

References