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Draft:Shahid Mahmood Baig

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  • Comment: PROMO - written like an advertisement. Also COI issues. Furthermore, this behavior is inappropriate. — Saqib (talk I contribs) 09:01, 3 August 2024 (UTC)
  • Comment: Firstly, WP:ANYBIO#1 (awards) does not take precedence over WP:GNG. Secondly, while the subject may meet WP:BARE, its current state fails GNG and reads like WP:RESUME. The article requires further cleanup and revision. There are also potential COI/UPE issues. — Saqib (talk I contribs) 14:09, 21 July 2024 (UTC)
For the general of Pakistan Army named Shahid Baig, see Shahid Baig Mirza.


Shahid Mahmood Baig
HI SI FPAS
شاہد محمود بیگ
Born (1960-10-09) October 9, 1960 (age 64)
Rawalpindi, Punjab, Pakistan
NationalityPakistani
Alma materDuke University, King Saud University, Bosphorus University, Quaid-i-Azam University
Known forFormer Chairman of the Pakistan Science Foundation (2020-2023)
SpouseShehla Anjum
Children3
AwardsHilal-e-Imtiaz
Sitara-e-Imtiaz
Scientific career
FieldsHuman Genetics, Disease gene identification, Health Biotechnology
InstitutionsPakistan Science Foundation, Health Services Academy, NIBGE

Shahid Mehmood Baig HI, SI, FPAS[1] (/ˈʃɑːhɪdməˈhuːdbeɪɡ/; SHAH-id-mə-HOOD-BAYG; Urdu: شاہد محمود بیگ; born 9 October 1960) is a Pakistani scientists known specializing in Human Genetics, Disease gene discovery and Health Biotechnology. He was awarded the Hilal-i-Imtiaz,[2][3] Sitara-i-Imtiaz, and elected as Fellow of the Pakistan Academy of Sciences.[4] He is pioneer of beta thalasemia prenatal dignosis kit in pakistan.[5]

In 1986, Baig started career as a Research Scholar at the Nuclear Medicine, Oncology and Radiotherapy Institute, joined the National Institute for Biotechnology and Genetic Engineering as a professor and head of the Human Molecular Genetics in 1995 until 2020, before taking the office of the Chairman of the Pakistan Science Foundation. Baig is the Dean of Life Sciences at the Health Services Academy, and a Member Syndicate at the University of Health Sciences, Lahore since January 2024.[6] He is also a Full Professor of Biology at the Department of Biological and Biomedical Sciences of the Aga Khan University.[7][8]

His research focuses on disease gene discovery and the elucidation of gene functions in inherited diseases prevalent in Pakistan. He has served as a visiting research professor at several universities, including Uppsala University, University of Copenhagen, and Duke University. He has authored or co-authored 155 peer-reviewed articles and supervised numerous PhD and postdoctoral fellows. His cumulative impact factor exceeds 700, and he has an H-index of 38.

Early Life and Education

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Shahid Mahmood Baig was born in Rawalpindi, a city in the Punjab province of Pakistan into a family belonging to the Baig clan. He received his BSc from Gordon College, MSc and MPhil in Biology from Quaid-i-Azam University. Baig holds two postdoctoral fellowships in Oncogenomics and Brain Tumour Research from Duke University Medical Center in 2012, and in Molecular biology and Genetics from King Saud University between 2000 and 2003. He earned his Ph.D. in Human Molecular Genetics from Quaid-i-Azam University, with research conducted at Bosphorus University in 1996, focusing on the molecular basis of β-thalassemia and its prenatal diagnosis by DNA analysis.[9]

Academic and Peofessionl Career

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He started his career as Research Scholar at Nuclear Medicine, Oncology and Radiotherapy Institute in 1986.[10] He completed PhD research on prenatal diagnosis of Beta thalassemia jointly from Bosphorus University and Quaid-i-Azam University in 1996. He joined the National Institute for Biotechnology and Genetic Engineering in 1995 and became a professor and head of Human Molecular Genetics till 2020.[11] He rejected the position of Vice Chancellor of a University.[12] He was appointed as the Director General of the National Institute of Electronics from March to December 27, 2023. Baig conducted his postdoctoral research at Oncogenomics Laboratory, Duke University Medical Center in 2012 and King Saud University from 2000 to 2003.[9] He has held several key positions including Chairman of the Pakistan Science Foundation from December 2020 to December 2023, Director General of the National Institute of Electronics from March to December 2023, and CEO of the Natural Sciences Linkages Program (NSLP) at PSF.[13] Baig is the Dean of Life Sciences at the Health Services Academy, and a Member Syndicate at the University of Health Sciences, Lahore since January 2024.[6] He was a Full Professor of Biology at the Department of Biological and Biomedical Sciences of the Aga Khan University.[7][8]

Research and Publications

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Dr. Baig has dedicated his research career to studying genetic disorders, with a focus on human genomics and disease gene discovery.[14] His work has significantly contributed to understanding the molecular basis of various inherited disorders, particularly in the consanguineous Pakistani population.[15] Dr. Baig's research aims to elucidate the genetic basis of Beta thalasemia, bradycardia, congenital deafness, neurodevelopmental and neurodegenerative diseases in Pakistani families. [16][5]

Beta Thalassemia

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One of Dr. Baig's notable research areas is beta-thalassemia, a genetic blood disorder characterized by reduced or absent hemoglobin production.[17] His PhD thesis, titled "Molecular basis of β-thalassemia in Turkey and its prenatal diagnosis by DNA analysis," laid the groundwork for his research in this field.[18] Dr. Baig's work on the molecular basis of beta-thalassemia in Turkey and its prenatal diagnosis by DNA analysis has been instrumental in developing screening and diagnostic tools for this genetic disorder.[19]

Prenatal Diagnostics

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Dr. Baig's research on beta-thalassemia has led to advancements in prenatal diagnostics.[20] His work on the molecular basis of beta-thalassemia in Pakistan and its prenatal diagnosis by DNA analysis has been instrumental in developing screening and diagnostic tools for this genetic disorder. [21][5] He is pioneer of beta thalasemia prenatal dignosis kit in pakistan.

Other Genetic Disorders

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In addition to beta-thalassemia, Dr. Baig has investigated the genetic basis of other disorders, including neurodevelopmental and neurodegenerative diseases.[22][23] His research projects have aimed to elucidate the molecular genetic basis of Beta thalasemia, bradycardia, congenital deafness, neurodevelopmental and neurodegenerative diseases in the Pakistani population and explore the genetics of ataxia and dyslexia in Pakistani families. [24][25][19]

Selected Publications

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Dr. Baig has an impressive publication record, with 155 peer-reviewed publications and a cumulative impact factor exceeding 750. Some of his most notable publications include:

  1. Baig, S.M., Azhar, A., Hassan, H., Baig, J.M., Qureshi, J.A., et al. (2006). Spectrum of β-thalassemia mutations in various regions of Punjab and Islamabad, Pakistan: establishment of prenatal diagnosis. Haematologica (Hematol Hematol J), 91(3): 13-15.
  2. Baig, S.M., Koschak, A., Lieb, A., Gebhart, M., Dafinger, C., Nurnberg, G., Ali, A., Ahmad, I., Martina, J., Sinnegger-Brauns, N., Brandt, N., Engel, J., Mangoni, M.E., Farooq, M., Khan, H.U., Nurnberg, P., Striessnig, J., Bolz, H.J. (2011). Cav1.3 (CACNA1D) loss of function causes a novel human channelopathy with bradycardia and congenital deafness. Nature Neuroscience, 14(1): 77-84.
  3. Baig, S.M. (2007). Molecular diagnosis of β-thalassemia by Multiplex ARMS-PCR: A cost-effective method for the developing countries. Prenatal Diagnosis, 27(26): 280-281.
  4. Baig, S.M., Sabih, D., Rahim, K., Azhar, A., Tariq, M., Hussain, M.S., Baig, U.R., Qureshi, J.A., Baig, S.A., Bakhtiar, S.M. (2012). β-Thalassemia in Pakistan: a pilot program on prenatal diagnosis in Multan. Journal of Pediatric Hematology/Oncology, 34(2): 90-92.
  5. Baig, S.M., Azhar, A., Hassan, H., Baig, J.M., Aslam, M., Din, M.A., Qureshi, J.A., Zaman, T. (2006b). Prenatal diagnosis of β-thalassemia in Southern Punjab, Pakistan. Prenatal Diagnosis, 26: 903-905.
  6. Baig, S.M., Din, M.A., Hassan, H., Baig, J.M., Azhar, A., Aslam, M., Farooq, M., Hussain, M.S., Rasool, M., Anjum, I., Nawaz, S., Qureshi, J.A., Zaman, T. (2008). Prevention of β-thalassemia in a large Pakistani family through cascade testing. Community Genetics, 11: 68-70.

His publications have received over 3,300 citations in the ISI Web of Science, with an average citation per item exceeding 19. Dr. Baig's h-index is 30 in ISI Web of Science, 39 in Google Scholar, and 37 excluding self-citations.

Awards

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Dr. Shahid Mahmood Baig has been recognized for his contributions to biomedical sciences with several prestigious awards:

  • Sitara-i-Imtiaz (2015) [1]
  • Hilal-e-Imtiaz (2023) [3]
  • Fellow of Pakistan Academy of Sciences (2023)
  • Life Time Achievement Award in Biology (ZSP, 2021)
  • Geers Foundation Award (Germany) for the best first author paper of the year 2011 on deafness in Nature Neuroscience. (2012)
  • Best paper of the year award by HEC. Annals of Neurology, 82(4):562-577. 2017
  • Award of Postdoctoral Fellowship from Oncogenomics Laboratory, Department of Pathology, Duke University Medical Center, Durham NC, USA. (2012)
  • Research Productivity Awards, by PCST Min of Sci and Tech. Pak. 2015-2016 (Category C), 2014-2015 (Category A), 2013-2014 (Category B), 2012-2013 (Category G), 2011-2012 (Category G), 2010-2011 (Category G)
  • Gold Medal for Scientist of the Year NIBGE-PAEC 2010-11
  • Best Performance Merit Certificate NIBGE-PAEC 2010-11
  • Postdoctoral Fellowship, KACST, King Saud University, KSA. Aug 2000-Apr 2003
  • PhD Fellowship, Ministry of Education Govt. of Pakistan-Turkey. 1992-95

Personal Life

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Baig is married to Dr. Shehla Anjum, PhD, is a former Consultant Biochemist and Molecular Biologist at the Children’s Hospital, PIMS in Islamabad. They have 3 daughters include Dr. Mehr un Nisa Shahid Baig, a Medical Officer at Federal General Hospital, Dr. Saira Shahid Baig, a FCPS Postgraduate Trainee in Radiation Oncology at NORI, and Dr. Aliza Shahid Baig, who recently completed her House Officer position at Shifa International Hospital.

See Also

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References

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  1. ^ a b APP (2024-03-24). "President Zardari confers civil awards on Pakistanis, foreign nationals". Dawn.com. Retrieved 2024-07-20.
  2. ^ "INTERVIEW OF DR. SHAHID MAHMOOD BAIG (HILAL-E-IMTIAZ)". www.radio.gov.pk. Retrieved 2024-07-20.
  3. ^ a b "President confers civil awards on Pakistani citizens, foreign nationals". Dunya News. 2023-08-18. Retrieved 2024-07-21.
  4. ^ "Science Talent Farming Scheme". stfs.psf.gov.pk. Retrieved 2024-07-20.
  5. ^ a b c Baig, Shahid Mahmood (2007). "Molecular diagnosis of beta-thalassemia by multiplex ARMS-PCR: a cost effective method for developing countries like Pakistan". Prenatal Diagnosis. 27 (6): 580–581. doi:10.1002/pd.1732. PMID 17546695.
  6. ^ a b "Dr. Shahid Mehmood Baig – Health Services Academy". Retrieved 2024-07-20.
  7. ^ a b "Faculty Profile | MC, PK | The Aga Khan University". www.aku.edu. Retrieved 2024-07-20.
  8. ^ a b "Department of Biological & Biomedical Sciences | Medical College, Pakistan | Aga Khan University". ecommons.aku.edu. Retrieved 2024-07-21.
  9. ^ a b Baig, Shahid. "Shahid Mahmood Baig, PhD, Sitara-i-Imtiaz Field of Specialization, International Academic and Research Positions".
  10. ^ "Ministry of National Food Security & Research". mnfsr.gov.pk. Retrieved 2024-07-21.
  11. ^ "Power struggle, mismanagement plague Ministry of Science and Technology". 2023-08-06. Retrieved 2024-07-20.
  12. ^ "HED moves summary for appointment of VCs to KP universities". www.thenews.com.pk. Retrieved 2024-07-21.
  13. ^ "Science-based solutions can help tackle global challenges: Speakers". 2023-11-15. Retrieved 2024-07-21.
  14. ^ Baig, S. M.; Din, M. A.; Hassan, H.; Azhar, A.; Baig, J. M.; Aslam, M.; Anjum, I.; Farooq, M.; Hussain, M. S.; Rasool, M. (2008). "Prevention of β-thalassemia in a large Pakistani family through cascade testing". Community Genetics. 11 (1): 68–70. doi:10.1159/000111641. PMID 18196920.
  15. ^ Ahmad, I.; Baig, S. M.; Abdulkareem, A. R.; Hussain, M. S.; Sur, I.; Toliat, M. R.; Nürnberg, G.; Dalibor, N.; Moawia, A.; Waseem, S. S.; Asif, M.; Nagra, H.; Sher, M.; Khan, M. M. A.; Hassan, I. (July 2017). "Genetic heterogeneity in Pakistani microcephaly families revisited". Clinical Genetics. 92 (1): 62–68. doi:10.1111/cge.12955. ISSN 0009-9163. PMID 28004384.
  16. ^ Kellaris, Georgios; Khan, Kamal; Baig, Shahid M.; Tsai, I-Chun; Zamora, Francisca Millan; Ruggieri, Paul; Natowicz, Marvin R.; Katsanis, Nicholas (December 2018). "A hypomorphic inherited pathogenic variant in DDX3X causes male intellectual disability with additional neurodevelopmental and neurodegenerative features". Human Genomics. 12 (1): 11. doi:10.1186/s40246-018-0141-y. ISSN 1479-7364. PMC 5831694. PMID 29490693.
  17. ^ Tüzmen, Şükrü; Tadmouri, Ghazi O.; Özer, Ayşe; Baig, Shahid M.; Özçelik, Hilmi; Başaran, Seher; Başak, A. Nazli (March 1996). "PRENATAL DIAGNOSIS OF β-THALASSAEMIA AND SICKLE CELL ANAEMIA IN TURKEY". Prenatal Diagnosis. 16 (3): 252–258. doi:10.1002/(SICI)1097-0223(199603)16:3<252::AID-PD839>3.0.CO;2-W. PMID 8710780.
  18. ^ Tadmouri, G.O.; Tüzmen, Ş.; Özçelik, H.; Özer, A.; Baig, S.M.; Senga, E.B.; Başak, A.N. (March 1998). "Molecular and population genetic analyses of β-Thalassemia in Turkey". American Journal of Hematology. 57 (3): 215–220. doi:10.1002/(SICI)1096-8652(199803)57:3<215::AID-AJH6>3.0.CO;2-Y. PMID 9495372.
  19. ^ a b Neuhaus, Christine; Eisenberger, Tobias; Decker, Christian; Nagl, Sandra; Blank, Cornelia; Pfister, Markus; Kennerknecht, Ingo; Müller-Hofstede, Cornelie; Charbel Issa, Peter; Heller, Raoul; Beck, Bodo; Rüther, Klaus; Mitter, Diana; Rohrschneider, Klaus; Steinhauer, Ute (September 2017). "Next-generation sequencing reveals the mutational landscape of clinically diagnosed Usher syndrome: copy number variations, phenocopies, a predominant target for translational read-through, and PEX26 mutated in Heimler syndrome". Molecular Genetics & Genomic Medicine. 5 (5): 531–552. doi:10.1002/mgg3.312. PMC 5606877. PMID 28944237.
  20. ^ Baig, Shahid Mahmood; Azhar, Ayesha; Hassan, Hammad; Baig, Jamshaid Mahmood; Aslam, Muhammad; Ud Din, Mohammad Amin; Qureshi, Javed Anver; Zaman, Tariq (October 2006). "Prenatal diagnosis of β-thalassemia in Southern Punjab, Pakistan". Prenatal Diagnosis. 26 (10): 903–905. doi:10.1002/pd.1523. ISSN 0197-3851. PMID 16821247.
  21. ^ Baig, S. M.; Din, M. A.; Hassan, H.; Azhar, A.; Baig, J. M.; Aslam, M.; Anjum, I.; Farooq, M.; Hussain, M. S.; Rasool, M. (2008). "Prevention of β-thalassemia in a large Pakistani family through cascade testing". Community Genetics. 11 (1): 68–70. doi:10.1159/000111641. PMID 18196920.
  22. ^ Hussain, Ghulam; Wang, Jing; Rasul, Azhar; Anwar, Haseeb; Imran, Ali; Qasim, Muhammad; Zafar, Shamaila; Kamran, Syed Kashif Shahid; Razzaq, Aroona; Aziz, Nimra; Ahmad, Waseem; Shabbir, Asghar; Iqbal, Javed; Baig, Shahid Mahmood; Sun, Tao (December 2019). "Role of cholesterol and sphingolipids in brain development and neurological diseases". Lipids in Health and Disease. 18 (1): 26. doi:10.1186/s12944-019-0965-z. ISSN 1476-511X. PMC 6347843. PMID 30683111.
  23. ^ Islam, Mehboob; Awan, Fazli Rabbi; Baig, Shahid Mahmood (September 2014). "Development of ARMS-PCR assay for genotyping of Pro12Ala SNP of PPARG gene: a cost effective way for case–control studies of type 2 diabetes in developing countries". Molecular Biology Reports. 41 (9): 5585–5591. doi:10.1007/s11033-014-3213-7. ISSN 0301-4851. PMID 25063576.
  24. ^ Nawaz, Sadia; Klar, Joakim; Wajid, Muhammad; Aslam, Muhammad; Tariq, Muhammad; Schuster, Jens; Baig, Shahid Mahmood; Dahl, Niklas (2009). "WNT10A missense mutation associated with a complete odonto-onycho-dermal dysplasia syndrome". European Journal of Human Genetics. 17 (12): 1600–1605. doi:10.1038/ejhg.2009.81. PMC 2987016. PMID 19471313.
  25. ^ Baig, Shahid M.; Koschak, Alexandra; Lieb, Andreas; Gebhart, Mathias; Dafinger, Claudia; Nürnberg, Gudrun; Ali, Amjad; Ahmad, Ilyas; Sinnegger-Brauns, Martina J.; Brandt, Niels (2011). "Loss of Cav1. 3 (CACNA1D) function in a human channelopathy with bradycardia and congenital deafness". Nature Neuroscience. 14 (1): 77–84. doi:10.1038/nn.2694. PMID 21131953.
[edit]
  1. Dr. Shahid Mahmood Baig at Pakistan Science Foundation
  2. Dr. Shahid Mahmood Baig publications at Researchgate
  3. Dr. Shahid Mahmood Baig publications at Google Scholar


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