Draft:Sarmentosin

Submission declined on 23 August 2024 by Remsense (talk).

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Declined by Remsense 20 days ago. Last edited by Citation bot 15 days ago. Reviewer: Inform author.

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Comment: The DOIs are broken. Many of these are medical claims that require additional scrutiny per WP:MEDRS before they can be published. Remsense ‥ 论 09:02, 23 August 2024 (UTC)

Sarmentosin is a glycoside and a natural product primarily derived from several plant species, notably Ribes nigrum (blackcurrants)^[1] and Rhodiola sacra.^[2] It has gained attention for its potential therapeutic applications, including recently as an inhibitor of monoamine oxidase (MAO), an enzyme involved in the metabolism of neurotransmitters. Research has highlighted the ability of sarmentosin to inhibit MAO-B, a subtype of the enzyme, suggesting its role in managing conditions related to monoamine neurotransmitter levels.

Chemical Structure

Sarmentosin has a molecular formula of C₁₁H₁₇NO₇ and a molecular weight of 275.25 g/mol. Its IUPAC name is (E)-2-(hydroxymethyl)-4-[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxybut-2-enenitrile. The compound is typically encountered as a powder and can be analyzed using various techniques such as NMR and mass spectrometry.

Sources

Sarmentosin is primarily extracted from plants in the Rhodiola genus and blackcurrants. These plants are known for their medicinal properties and are found in temperate regions. The extraction process often involves solvent extraction and chromatographic techniques to isolate the compound in a pure form. Recent studies have specifically identified sarmentosin as a key bioactive compound in blackcurrants that contributes to its MAO inhibitory effects¹.

MAO Inhibition and other Biological Activity

Research has identified several significant biological activities associated with sarmentosin:

Research has demonstrated that sarmentosin exhibits significant inhibitory effects on MAO-B activity. A clinical study confirmed that consuming blackcurrant-derived sarmentosin significantly inhibited platelet MAO-B activity, with measurable effects observed two hours post-consumption. The inhibition was dose-dependent, with both 42 mg and 84 mg doses leading to significant reductions in MAO-B activity compared to baseline levels .In addition to its effects on MAO-B, sarmentosin has also been suggested to inhibit MAO-A, although further research is needed to clarify its activity against both isoforms³ . The ability of sarmentosin to inhibit these enzymes is particularly relevant, as MAO inhibitors are associated with various therapeutic effects, including the modulation of mood disorders and neurodegenerative diseases.

Therapeutic Potential

Given its MAO inhibitory properties, sarmentosin is being investigated for various therapeutic applications, particularly in:

Mental Health: By inhibiting MAO-B, sarmentosin may help regulate neurotransmitter levels, potentially benefiting conditions such as depression and anxiety.
Neuroprotection: The compound's ability to modulate MAO activity suggests a role in protecting against neurodegenerative diseases.

Research has also identified several other significant biological activities associated with sarmentosin:

Antimicrobial Properties: Sarmentosin has demonstrated effectiveness against various bacterial strains, making it a candidate for developing new antimicrobial agents.
Antioxidant Activity: The compound exhibits antioxidant properties, which are vital for protecting cells from oxidative stress and related diseases.
Anti-inflammatory Effects: Studies indicate that sarmentosin may possess anti-inflammatory properties, potentially aiding in the treatment of chronic inflammatory conditions.
Cancer Research: Sarmentosin has been found to inhibit the mTOR signaling pathway and induce autophagy-dependent apoptosis in human hepatocellular carcinoma (HCC) cells, suggesting its potential role in cancer therapy⁴.

Conclusion

Sarmentosin represents a significant area of interest within natural product chemistry and pharmacology. Its unique properties and potential health benefits warrant further investigation, and it may play an essential role in the development of new therapeutic agents in the future.

References

^ Lomiwes, D.; Günther, C. S.; Bloor, S. J.; Trower, T. M.; Ngametua, N.; Kanon, A. P.; Jensen, D. A.; Lo, K.; Sawyer, G.; Walker, E. G.; Hedderley, D.; Cooney, J. M. (2024). "Identification of Sarmentosin as a Key Bioactive from Blackcurrants (Ribes nigrum) for Inhibiting Platelet Monoamine Oxidase in Humans". Journal of Agricultural and Food Chemistry. 72 (30): 16777–16789. doi:10.1021/acs.jafc.4c03802. PMC 11299169. PMID 39028868.
^ https://doi.org/10.1016/j.phymed.2022.153788

Identification of Sarmentosin as a Key Bioactive from Blackcurrants (Ribes nigrum) for Inhibiting Platelet Monoamine Oxidase in Humans. (2024). J Agric Food Chem. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11299169/
Jiang, Z., Yang, X., Han, Y., Li, J., Hu, C., Liu, C., & Xiao, W. (2022). Sarmentosin promotes USP17 and regulates Nrf2-mediated mitophagy and cellular oxidative stress to alleviate APAP-induced acute liver failure. Phytomedicine, 92, 153788. https://doi.org/10.1016/j.phymed.2022.153788
Bioactives and Their Uses. (2023). WIPO Patent Application. Retrieved from https://www.sumobrain.com/patents/wipo/Bioactives-their-uses/WO2023163606A1.html
Sarmentosin Induces Autophagy-dependent Apoptosis via Activation of Nrf2 in Hepatocellular Carcinoma. (2023). Cancer Letters. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10318286/

[1] Lomiwes, D.; Günther, C. S.; Bloor, S. J.; Trower, T. M.; Ngametua, N.; Kanon, A. P.; Jensen, D. A.; Lo, K.; Sawyer, G.; Walker, E. G.; Hedderley, D.; Cooney, J. M. (2024). "Identification of Sarmentosin as a Key Bioactive from Blackcurrants (Ribes nigrum) for Inhibiting Platelet Monoamine Oxidase in Humans". Journal of Agricultural and Food Chemistry. 72 (30): 16777–16789. doi:10.1021/acs.jafc.4c03802. PMC 11299169. PMID 39028868.

[2] ttps://doi.org/10.1016/j.phymed.2022.153788

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