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Draft:Ming Hammond

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  • Comment: Wikipedia articles should summarise what makes one notable, not try to provide a comprehensive catalogue of someone's entire output. Especially the 'Publications' section is far too long, please cut down to the few most notable items only. (Ditto, other sections.)
    Note also that list chronologies should run from oldest to newest. DoubleGrazing (talk) 15:49, 24 April 2024 (UTC)
Quick Info
Born in: Owings Mills Maryland
Bachelors of Science: California Institute of Technology
Ph.D: University of California, Berkeley
Current Occupation: Professor at the University of Utah
Lab: Hammond Lab

Ming Hammond

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Background

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Ming Hammond is a Taiwanese Chemist. She currently works at the University of Utah as a professor of Biological Chemistry and runs The Hammond Lab. Her research focuses on studying cyclic dinucleotides and their use in mammalian cells and bacteria for signaling as well as engineering nucleic acids to be used for gene control and imaging.

Early Life and Education

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Ming Hammond is a Taiwanese Chemist who was raised in Owings Mills Maryland. Neither of her parents were in STEM and she was the first person in her family to obtain a Ph.D. From 1996-2000 Ming Hammond spent her early college years in Pasadena California at the California Institute of Technology where she was awarded the Beckman Scholarship and completed her B.S. in Chemistry. Her work as an undergraduate in a research lab discovering enzyme activity inspired the rest of her career. She then continued on to further her education by obtaining a Ph.D. in Chemistry at University of California, Berkeley in 2005. After spending a summer in Heidelberg Germany, she went on to work as a Postdoctoral Fellow in Molecular Biology from 2005-2009 at Yale University in New Haven, CT studying riboswitch biology. Doctor Hammond has over 50 publications and is most recognized for her work developing the first fluorescent RNA biol switches to monitor cell activity utilizing riboswitch and fluorescent-binding technology. These biosensors have been utilized as she furthers her career studying bacteria signaling cAG. Her work allows us to better understand cellular activity which has great potential to change the research and health field alike with future implications such as preventing the spread of diseases.

Research

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Hammond started her career early in her undergraduate studies through Cal Tech’s work/study program where she studied protein complexes. Shortly after finishing her research fellowship at Yale, she started her career in academia as an assistant professor. From 2009 to 2018, she worked at UC Berkeley through the Department of Chemistry and the Department of Molecular and Cell Biology. During her time at Berkeley, she also became affiliated with the NIGMS Center for RNA Systems Biology, the Synthetic Biology Institute, the California Institute for Quantitative Bioscience, and the Lawrence Berkeley National Laboratory. In 2018, Hammond moved to become first an Associate Professor, and later a Professor, with the University of Utah, Department of Chemistry. She became an executive committee member for the Henry Eyring Center for Cell and Genome Science in 2018 as well as the Co-Director of the NSF Research Experiences for Undergraduate Program in 2019 and continues to be affiliated with these programs. From 2020 to 2023, she also served as a Co-Director for the U of U Beckman Scholar Program through the College of Science.

Hammond received an NIH Director's New Innovator Award in 2011[1] to advance research in live cell imaging of RNAs,[2] and her major research contributions focus on the discovery of new biosensors and signaling pathways. In particular, her work has focused on designing fluorescent biosensors using a circularly permuted roboswitch, SAM-I.[3] Using in vitro and in vivo fluorescent assays, it was shown that circularly permuted riboswitches could retain and/or improve ligand binding and conformational switching. This finding has implications for regulating gene expression, as well as potential for application in other RNA devices. Hammond has also contributed to the design of two new RNA-based fluorescent (RBF) biosensors with advantages for monitoring dynamic processes [4] as well as the Venus-YcgR-NLuc (VYN) sensors for applications like diagnostic and genetically encodable tools for monitoring cdi-GMP in live cells, including bacteria in various environments [5]. Other notable works include a demonstration of the functionality of an exogenously inducible gene circuit in plants for applications in spaceflight, indicating that synthetic biology in plants could be a feasible solution for long-distance space travel [6]

Hammond’s lab continues to focus on the design of RNA-based fluorescent biosensors for cyclic dinucleotides[7]. Live cell imaging experiments demonstrate that these biosensors had a fluorescent component that could confirm in vivo enzyme production. This work focused on the discovery of an RNA-based fluorescent biosensor specific to the cyclic dinucleotide cAG (cyclic AMP-GMP). The bacteria Geobactr produces cAG through GEMM-I roboswitches and GGDEF enzymes, which were previously found to be specific to a different cyclic dinucleotide [8]. Related work describes a full kinetic model designed to reveal mechanisms of the in vivo specificity of a GGDEF enzyme associated with bacterial di-GMP signaling, another cyclic dinucleotide[9]. This discovery has implications for bacterial detection and received much attention including, the 2015 Signaling Breakthrough of the Year Award[10][11][12]. In conjunction with Russel Vance from the University of California, Berkeley, it was proved that this discovered cyclic GMP-AMP signaling can function as an innate immune sensor in all three domains of life [13]

Patents

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  • 2005 US Pat Appl Pub : Peptide beta-strand mimics based on pyridinones, pyrazinones, pyridazinones, and triazinones
  • 2013 US Pat 13/747,395 : A P5SM suicide exon for regulating gene expression
  • 2016 US Pat Appl 62/438,126 : Methods of producing cyclic dinucleotides
  • 2016 US. Pat Appl 62/349,556 : Fluorescent biosensor for 2’, 3’-cGAMP
  • 2015 US. Pat Appl 62/246,953 : A fluorescent biosensor for high throughout screening of methyltransferase activity
  • 2024 US. Pat Appl 11,873,319 : Cyclic di-nucleotide induction of type I interferon

Selected Honors and Awards

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  • 2024 Kavli Fellow, National Academy of Sciences
  • 2016 Women in Science Award, Chau Hoi Sheun Foundation
  • 2011-2016 National Institutes of Health New Innovator Award[1]
  • 2011 Regents’ Junior Faculty Fellowship (UC Berkeley)
  • 2010 - 2013 Chevron Chair of Chemistry (UC Berkeley)
  • 2010 Thieme Chemistry Journal Award
  • 2008-2016 Burroughs Wellcome Fund Career Award at the Scientific Interface
  • 2000-2005 Howard Hughes Medical Institute Predoctoral Fellowship
  • 2000 National Science Foundation Graduate Fellowship
  • 2000 Richard P. Schuster Memorial Prize in Chemistry
  • 1999-2000  Carnation Merit Award
  • 1999 Arie J. Haagen-Smit Memorial Award
  • 1998-1999 Beckman Scholar Fellowship
  • 1998-1999 Caltech Prize Award

Notable Publications

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Manna, S., Kimoto, M., Truong, J., Bommisetti, P., Peitz, A., Hirao, I., Hammond, M. C. “Systematic mutation and unnatural base pair incorporation improves riboswitch-based biosensor response time” ACS Sensors (2023) 8, 4468-4472. 10.1021/acssensors.3c01266 (preprint: 10.26434/chemrxiv-2023-xlth4)[14]

Mumbleau, M. M., Meyer, M. R., Hammond, M. C. “Determination of in vitro and cellular turn-on kinetics for fluorogenic RNA aptamers” J Vis Exp (2022) 186, e64367. (Invited Paper)[15]

Tan, Z.*, Chan, C. H.*, Maleska, M., Banuelos-Jara, B., Lohman, B. K., Ricks, N. J., Bond, D. R., Hammond, M. C. “The signaling pathway that cGAMP riboswitches found: analysis and application of riboswitches to study cGAMP signaling in Geobacter sulfurreducens” Int J Mol Sci (2022) 23, 1183. (Invited Paper)[16]

Wright, T. A., Dippel, A. B., Hammond, M. C. “Cyclic di-GMP signaling gone astray: cGAMP signaling via Hypr GGDEF and HD-GYP enzymes” In Chou, S.-H., Guilliani, N., Lee, V., Romling, U. (ed), Microbial Cyclic Di-Nucleotide Signaling. (Invited Book Chapter)[17]

Hallberg, Z. F.*, Chan, C. H.*, Wright, T. A., Kranzusch, P. J., Doxzen, K. W., Park, J. J., Bond, D. R., Hammond, M. C. “Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration” ELife (2019) e43959[9]

Truong, J., Hsieh, Y. F., Jia, G., Hammond, M. C. “Circular permutation strategies for engineering RNA-based fluorescent biosensors”, Methods (2018) 143, 102-109. (Invited Paper)[3]

Pan, Y., Duncombe, T. A., Kellenberger, C. A., Hammond, M. C., Herr, A. E. “High-throughput electrophoretic mobility shift assays for quantitative analysis of molecular binding reactions” Anal Chem (2014) 86, 10357-10364.[18]

Hickey, S. F., Hammond, M. C. “Structure-guided design of fluorescent S-adenosylmethionine analogs for a high-throughput screen to target SAM-I riboswitch RNAs” Chem Biol (2014) 21, 345-356.[19]

References

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  1. ^ a b "NIH Director's New Innovator Award: 2011 Awardees". National Institutes of Health. Retrieved May 30, 2024.
  2. ^ "A Chemical Biology Approach to Tagging RNAs in Live Cells". reporter.nih.gov. Retrieved May 30, 2024.
  3. ^ a b Truong, Johnny; Hsieh, Yu-Fang; Truong, Lynda; Jia, Guifang; Hammond, Ming C (2018-07-01). "Designing fluorescent biosensors using circular permutations of riboswitches". Methods (San Diego, Calif.). 143: 102–109. doi:10.1016/j.ymeth.2018.02.014. ISSN 1046-2023. PMC 6051913. PMID 29458090.
  4. ^ Manna, Sudeshna; Truong, Johnny; Hammond, Ming C. (2021-03-19). "Guanidine Biosensors Enable Comparison of Cellular Turn-on Kinetics of Riboswitch-Based Biosensor and Reporter". ACS Synthetic Biology. 10 (3): 566–578. doi:10.1021/acssynbio.0c00583. ISSN 2161-5063. PMC 7985839. PMID 33646758.
  5. ^ Dippel, Andrew B.; Anderson, Wyatt A.; Park, Jin Hwan; Yildiz, Fitnat H.; Hammond, Ming C. (2020-04-17). "Development of Ratiometric Bioluminescent Sensors for in Vivo Detection of Bacterial Signaling". ACS Chemical Biology. 15 (4): 904–914. doi:10.1021/acschembio.9b00800. ISSN 1554-8929. PMC 7233196. PMID 32186367.
  6. ^ Kitto, Rebekah Z.; Dhillon, Yadvender; Bevington, James; Horne, Mera; Giegé, Philippe; Drouard, Laurence; Heintz, Dimitri; Villette, Claire; Corre, Nicolas; Arrivé, Mathilde; Manefield, Michael J.; Bowman, Robert; Favier, Jean-Jacques; Osborne, Barnaby; Welch, Chris (2021). "Synthetic biological circuit tested in spaceflight". Life Sciences in Space Research. 28: 57–65. Bibcode:2021LSSR...28...57K. doi:10.1016/j.lssr.2020.09.002. ISSN 2214-5532. PMID 33612180.
  7. ^ Kellenberger, Colleen A.; Wilson, Stephen C.; Sales-Lee, Jade; Hammond, Ming C. (2013-04-03). "RNA-Based Fluorescent Biosensors for Live Cell Imaging of Second Messengers Cyclic di-GMP and Cyclic AMP-GMP". Journal of the American Chemical Society. 135 (13): 4906–4909. doi:10.1021/ja311960g. ISSN 0002-7863. PMC 3775879. PMID 23488798.
  8. ^ Kellenberger, Colleen A.; Wilson, Stephen C.; Hickey, Scott F.; Gonzalez, Tania L.; Su, Yichi; Hallberg, Zachary F.; Brewer, Thomas F.; Iavarone, Anthony T.; Carlson, Hans K.; Hsieh, Yu-Fang; Hammond, Ming C. (2015-04-28). "GEMM-I riboswitches from Geobacter sense the bacterial second messenger cyclic AMP-GMP". Proceedings of the National Academy of Sciences. 112 (17): 5383–5388. Bibcode:2015PNAS..112.5383K. doi:10.1073/pnas.1419328112. ISSN 0027-8424. PMC 4418906. PMID 25848022.
  9. ^ a b Hallberg, Zachary F; Chan, Chi Ho; Wright, Todd A; Kranzusch, Philip J; Doxzen, Kevin W; Park, James J; Bond, Daniel R; Hammond, Ming C (2019-04-09). O'Toole, George; Storz, Gisela; Malone, Jacob G (eds.). "Structure and mechanism of a Hypr GGDEF enzyme that activates cGAMP signaling to control extracellular metal respiration". eLife. 8: e43959. doi:10.7554/eLife.43959. ISSN 2050-084X. PMC 6456294. PMID 30964001.
  10. ^ Adler, Elizabeth M. (2016-01-05). "2015: Signaling Breakthroughs of the Year". Science Signaling. 9 (409): eg1. doi:10.1126/scisignal.aad9795. ISSN 1945-0877. PMID 26732760.
  11. ^ "Hammond's high risk/high reward research pays off | College of Chemistry". chemistry.berkeley.edu. Retrieved 2024-04-24.
  12. ^ "Generating electricity from bacteria". eLife. 2019-04-09. Retrieved 2024-04-24.
  13. ^ Diner, Elie J.; Burdette, Dara L.; Wilson, Stephen C.; Monroe, Kathryn M.; Kellenberger, Colleen A.; Hyodo, Mamoru; Hayakawa, Yoshihiro; Hammond, Ming C.; Vance, Russell E. (2013-05-30). "The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING". Cell Reports. 3 (5): 1355–1361. doi:10.1016/j.celrep.2013.05.009. ISSN 2211-1247. PMC 3706192. PMID 23707065.
  14. ^ Manna, Sudeshna; Kimoto, Michiko; Truong, Johnny; Bommisetti, Praneeth; Peitz, Ava; Hirao, Ichiro; Hammond, Ming C. (2023-12-22). "Systematic Mutation and Unnatural Base Pair Incorporation Improves Riboswitch-Based Biosensor Response Time". ACS Sensors. 8 (12): 4468–4472. doi:10.1021/acssensors.3c01266. ISSN 2379-3694. PMC 10749561. PMID 37878677.
  15. ^ Mumbleau, Madeline M.; Meyer, Madeline R.; Hammond, Ming C. (2022-08-09). "Determination of In Vitro and Cellular Turn-on Kinetics for Fluorogenic RNA Aptamers". Journal of Visualized Experiments: JoVE (186). doi:10.3791/64367. ISSN 1940-087X. PMC 9701086. PMID 36036622.
  16. ^ Tan, Zhesen; Chan, Chi Ho; Maleska, Michael; Banuelos Jara, Bryan; Lohman, Brian K.; Ricks, Nathan J.; Bond, Daniel R.; Hammond, Ming C. (2022-01-21). "The Signaling Pathway That cGAMP Riboswitches Found: Analysis and Application of Riboswitches to Study cGAMP Signaling in Geobacter sulfurreducens". International Journal of Molecular Sciences. 23 (3): 1183. doi:10.3390/ijms23031183. ISSN 1422-0067. PMC 8835794. PMID 35163114.
  17. ^ Wright, Todd A.; Dippel, Andrew B.; Hammond, Ming C. (2020), Chou, Shan-Ho; Guiliani, Nicolas; Lee, Vincent T.; Römling, Ute (eds.), "Cyclic di-GMP Signaling Gone Astray: Cyclic GAMP Signaling via Hypr GGDEF and HD-GYP Enzymes", Microbial Cyclic Di-Nucleotide Signaling, Cham: Springer International Publishing, pp. 595–611, doi:10.1007/978-3-030-33308-9_34, ISBN 978-3-030-33308-9, retrieved 2024-04-24
  18. ^ Pan, Yuchen; Duncombe, Todd A.; Kellenberger, Colleen A.; Hammond, Ming C.; Herr, Amy E. (2014-10-21). "High-Throughput Electrophoretic Mobility Shift Assays for Quantitative Analysis of Molecular Binding Reactions". Analytical Chemistry. 86 (20): 10357–10364. doi:10.1021/ac502700b. ISSN 0003-2700. PMC 4204909. PMID 25233437.
  19. ^ Hickey, Scott F.; Hammond, Ming C. (2014-03-20). "Structure-guided design of fluorescent S-adenosylmethionine analogs for a high-throughput screen to target SAM-I riboswitch RNAs". Chemistry & Biology. 21 (3): 345–356. doi:10.1016/j.chembiol.2014.01.004. ISSN 1879-1301. PMC 4074398. PMID 24560607.
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https://www.the-hammond-lab.com/

https://bioscience.utah.edu/faculty/hammond/index.php

https://faculty.utah.edu/bytes/curriculumVitae.hml?id=u6018214

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