Draft:Mikala Egeblad
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Last edited by Cjhallinan (talk | contribs) 0 seconds ago. (Update) |
Mikala Egeblad is an internationally renowned cancer researcher who is a professor of Oncology and Cell Biology at Johns Hopkins School of Medicine.
Education
[edit]Egeblad attended the University of Copenhagen where she earned a bachelor’s degree in medicine, a master’s degree in human biology and a PhD in cancer biology. Following her PhD, she trained as a postdoctoral fellow in Zena Werb’s laboratory at University of California, San Francisco. While there, she used mouse models to research the cancerous tumor microenvironment, focusing on the contribution of the innate immune system and matrix metalloproteinases. Egeblad also co-developed a technique of intravital imaging, using a 2-photon microscope and silicone window implant to capture immune cell behavior in real time.
Career
[edit]In 2009, she established her own lab at Cold Spring Harbor Laboratory in New York where she continued to study the tumor microenvironment, publishing influential findings on the interactions between cancer cells and their surrounding stromal cells. Her work has helped define the mechanisms by which neutrophils induce the progression of cancer and its metastasis.
In 2023, Egeblad joined Johns Hopkins School of Medicine as a Bloomberg Distinguished Professor, where she has been appointed as a professor in both the Department of Cell Biology and the Department of Oncology. Egeblad is also a member of the Convergence Institute, a co-director of the Cancer Invasion Metastasis Program in the Sidney Kimmel Comprehensive Cancer Center and an associate director of the Giovanis Institute for Translational Cell Biology at Hopkins.
Research
[edit]Mikala Egeblad’s work focuses on understanding how the body’s immune response influences cancer progression, metastasis, and therapy outcomes. Her lab’s research centers on the tumor microenvironment—the immune cells, blood vessels, stroma and signaling pathways surrounding a tumor—and how this environment shapes cancer growth and spread. Her lab has made groundbreaking discoveries regarding the role of neutrophils and their extracellular traps (NETs) in the advancement of cancer. Additionally, the Egeblad lab has identified a crucial link between stress, immune response and cancer metastasis.
With the standing goal of preventing metastasis and finding more effective ways to fight cancer, Egeblad and her lab continue to drive projects across a variety of cancer models, using cutting-edge imaging techniques and innovative approaches.