Draft:Melanolipofuscin
![]() | Draft article not currently submitted for review.
This is a draft Articles for creation (AfC) submission. It is not currently pending review. While there are no deadlines, abandoned drafts may be deleted after six months. To edit the draft click on the "Edit" tab at the top of the window. To be accepted, a draft should:
It is strongly discouraged to write about yourself, your business or employer. If you do so, you must declare it. Where to get help
How to improve a draft
You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article. Improving your odds of a speedy review To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags. Editor resources
Last edited by UtherSRG (talk | contribs) 29 days ago. (Update) |
Melanolipofuscin is a form of melanosome that contains lipofuscin. It is accumulating in the retinal pigment epithelium of aged human eyes. It is of greatest risk to develop age related macular degeneration [1] It was recently shown that it originates when melanin loose the capacity to degrade lipofuscin and its precursors [2] Melanolipofuscin can be degraded by melanin and drugs [3]
References
[edit]- ^ Feeney L. Lipofuscin and melanin of human retinal pigment epithelium. Fluorescence, enzyme cytochemical, and ultrastructural studies. Invest Ophthalmol Vis Sci. 1978;17(7):583-600.
- ^ Lyu Y, Tschulakow A, Schraermeyer U. Melanosomes degrade lipofuscin and precursors that are derived from photoreceptor membrane turnover in the retinal pigment epithelium—an explanation for the origin of the melanolipofuscin granule. 2022.; bioRxiv doi: https://doi.org/10.1101/2022.02.16.480523
- ^ Lyu Y, Tschulakow AV, Wang K, Brash DE, Schraermeyer U. Chemiexcitation and melanin in photoreceptor disc turnover and prevention of macular degeneration. Proc Natl Acad Sci U S A. 2023;120(20):e2216935120.