Draft:ERICH6
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ERICH6 is a gene that encodes for the glutamate-rich 6 protein[1]. In humans, it is found in the 44th open reading frame of the 3rd chromosome[2]. ERICH6 is one of 6 currently found ERICH genes in the human genome (labeled ERICH1-ERICH6), however no linkage has been found in these genes besides their high concentration of glutamate[3].
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Gene
[edit]Locus
[edit]ERICH6 is a protein-coding gene found on the reverse (-) strand of chromosome 3 at the locus 3q25.1, on the long arm of the chromosome[4]
Gene Neighborhood
[edit]The SIAH2 gene is located upstream of ERICH6 on the third chromosome. Additionally, the SELENOT gene is located downstream.
Aliases
[edit]ERICH6 is also known as c3orf44, FAM194A and ERICH6A.
Transcript
[edit]mRNA
[edit]ERICH6's mRNA transcript is 2021 nucleotides long. These nucleotides encode for a 663 amino acid protein. There are 14 exons and 13 introns, as well as two isoforms. Isoform 1 is the longer, with isoform 2 missing exon 1.
Protein
[edit]
The protein encoded by ERICH6 is known as glutamate-rich 6 protein. The molecular weight of glutamate-rich 6 is about 75kD[7]. There are two disordered regions within the protein. The protein contains a FAM194 region, which is highly conserved.
Expression
[edit]ERICH6 is expressed at low levels throughout the body[8]. The expression pattern of this protein is restricted to pre-meiotic germ cells, which suggests it could be implicated in cell division or DNA replication during the early stages of spermatogenesis[9].
Homology
[edit]Paralogs
[edit]There are two known paralogs of ERICH6. ERICH6B is located on Chromosome 13 while c3orf20 is on Chromosome 3.
| Name | Accesion Number | Location in human genome | Sequence similarity to ERICH6 | E-value |
|---|---|---|---|---|
| ERICH6B | NP_872348 | c13 q14.13 | 32.6% | 8.00E-20 |
| c3orf20 | AAH30599.1 | c3 p25.1 | 29.93% | 3.00E-12 |
Orthologs
[edit]
ERICH6 was found to be conserved in all mammals, reptiles, fish and most invertebrates[10]. The most distance ortholog was found to evolve 758 million years ago[11]. It was not found in any arthropods.
Gene Evolution
[edit]ERICH6 is relatively fast evolving. It has evolution values (corrected M) more similar to the quick evolving Fibrinogen alpha chain gene. It is quicker evolving than the Cytochrome c gene.
Clinical Significance
[edit]ERICH6 as a lncRNA has a strong correlation with Immune cell infiltration[12]. Mutations in the 5’ UTR of ERICH6 (T to C switches) were found to cause tumor regression in Tasmanian Devils[13].
References
[edit]- ^ "ERICH6 glutamate rich 6 [Homo sapiens (human)] - Gene - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-10-20.
- ^ "glutamate-rich protein 6 isoform 1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2024-10-20.
- ^ "ERICH6".
- ^ "Supplemental Information 3: Gene list of circadian rhythm-related genes obtained from GeneCards". doi:10.7717/peerj.13165/supp-3.
{{cite web}}: Missing or empty|url=(help) - ^ "AlphaFold Protein Structure Database". alphafold.ebi.ac.uk. Retrieved 2024-12-11.
- ^ "DOG 2.0 - Protein Domain Structure Visualization". dog.biocuckoo.org. Retrieved 2024-12-11.
- ^ "SAPS Protein Analysis". www.ebi.ac.uk. Retrieved 2024-12-11.
- ^ Fagerberg, Linn; Hallström, Björn M.; Oksvold, Per; Kampf, Caroline; Djureinovic, Dijana; Odeberg, Jacob; Habuka, Masato; Tahmasebpoor, Simin; Danielsson, Angelika; Edlund, Karolina; Asplund, Anna; Sjöstedt, Evelina; Lundberg, Emma; Szigyarto, Cristina Al-Khalili; Skogs, Marie (2014). "Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics". Molecular & Cellular Proteomics: MCP. 13 (2): 397–406. doi:10.1074/mcp.M113.035600. ISSN 1535-9484. PMC 3916642. PMID 24309898.
- ^ Pineau, Charles; Hikmet, Feria; Zhang, Cheng; Oksvold, Per; Chen, Shuqi; Fagerberg, Linn; Uhlén, Mathias; Lindskog, Cecilia (2019-12-06). "Cell Type-Specific Expression of Testis Elevated Genes Based on Transcriptomics and Antibody-Based Proteomics". Journal of Proteome Research. 18 (12): 4215–4230. doi:10.1021/acs.jproteome.9b00351. ISSN 1535-3893. PMID 31429579.
- ^ "BLAST: Basic Local Alignment Search Tool". blast.ncbi.nlm.nih.gov. Retrieved 2024-12-11.
- ^ "TimeTree :: The Timescale of Life". timetree.org. Retrieved 2024-12-11.
- ^ Liu, Jinhui. "Development of a novel immune-related lncRNA signature as a prognostic classifier for endometrial carcinoma". International Journal of Biological Sciences.
- ^ Margres, Mark J; Ruiz-Aravena, Manuel; Hamede, Rodrigo; Chawla, Kusum; Patton, Austin H; Lawrance, Matthew F; Fraik, Alexandra K; Stahlke, Amanda R; Davis, Brian W; Ostrander, Elaine A; Jones, Menna E; McCallum, Hamish; Paddison, Patrick J; Hohenlohe, Paul A; Hockenbery, David (2020-08-01). "Spontaneous Tumor Regression in Tasmanian Devils Associated with RASL11A Activation". Genetics. 215 (4): 1143–1152. doi:10.1534/genetics.120.303428. ISSN 1943-2631. PMC 7404226. PMID 32554701.