Draft:Biological noise
| Submission declined on 3 August 2024 by Jlwoodwa (talk). Neologisms are not considered suitable for Wikipedia unless they receive substantial use and press coverage; this requires strong evidence in independent, reliable, published sources. Links to sites specifically intended to promote the neologism itself do not establish its notability.
Where to get help
How to improve a draft
You can also browse Wikipedia:Featured articles and Wikipedia:Good articles to find examples of Wikipedia's best writing on topics similar to your proposed article. Improving your odds of a speedy review To improve your odds of a faster review, tag your draft with relevant WikiProject tags using the button below. This will let reviewers know a new draft has been submitted in their area of interest. For instance, if you wrote about a female astronomer, you would want to add the Biography, Astronomy, and Women scientists tags. Editor resources
|  |
Biological noise, the flip side of biological function, is defined by reproducible events (i.e., not experimental errors) that occur in living cells due to imperfection (i.e., lack of fidelity) of a biological process.[1][2][3]The concept was coined and studied in the Kevin Struhl Laboratory at the Harvard Medical School. The predecessor to the concept is the opinion piece about the transcriptional noise[4], which was defined as non-functional transcription as opposed to the transcriptional noise that reflects gene expression variability. To study biological noise, researcher Zlata Gvozdenov introduced in the cells random DNA sequence artificial chromosome, which is functionally irrelevant.[1] She then compared those molecular events to the endogenous, functional chromosomes. By definition, all events associated with the random sequence chromosome, which is not needed for the cellular functions, are biological noise. Results suggested that the amount of biological noise in the yeast cells is comparable to the functional molecular events, challenging canonical approach to biology that aims to find a functional connection behind every biomolecular event.[3][5]
References
[edit]- ^ a b Gvozdenov, Zlata; Barcutean, Zeno; Struhl, Kevin (2023-06-01). "Functional analysis of a random-sequence chromosome reveals a high level and the molecular nature of transcriptional noise in yeast cells". Molecular Cell. 83 (11): 1786–1797.e5. doi:10.1016/j.molcel.2023.04.010. ISSN 1097-2765. PMC 10247422. PMID 37137302.
- ^ "ScienceDirect.com | Science, health and medical journals, full text articles and books". www.sciencedirect.com. Retrieved 2024-08-02.
- ^ a b Fragile Nucleosome (2022-12-29). Zlata Gvozdenov: Distinguishing Biological Function from Biological Noise. Retrieved 2024-08-02 – via YouTube.
- ^ Struhl, Kevin (February 2007). "Transcriptional noise and the fidelity of initiation by RNA polymerase II". Nature Structural & Molecular Biology. 14 (2): 103–105. doi:10.1038/nsmb0207-103. ISSN 1545-9985. PMID 17277804.
- ^ Dr. Joel Duff (2023-05-21). Random-Sequence Chromosome Organizes Itself and Transcribes at High Level. Retrieved 2024-08-02 – via YouTube.