Draft:4''-Fluoro-Ohlofentanil

4"-Fluoro-Ohlofentanil
Identifiers
	IUPAC name methyl 1‐[2‐(4‐fluorophenyl)‐2‐hydroxyethyl]‐3‐methyl‐4‐(N‐phenylpropanamido)piperidine‐4‐carboxylate;
Chemical and physical data
Formula	C25H31FN2O4
Molar mass	442.531 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCC(=O)N(c1ccccc1)C2(CCN(CC2C)CC(O)c3ccc(F)cc3)C(=O)OC;
	InChI InChI=1S/C25H31FN2O4/c1-4-23(30)28(21-8-6-5-7-9-21)25(24(31)32-3)14-15-27(16-18(25)2)17-22(29)19-10-12-20(26)13-11-19/h5-13,18,22,29H,4,14-17H2,1-3H3; Key:MXLCFFZKJIWXLO-UHFFFAOYSA-N;

Submission declined on 8 December 2024 by Pygos (talk).

This draft's references do not show that the subject qualifies for a Wikipedia article. In summary, the draft needs multiple published sources that are:

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Declined by Pygos 47 days ago. Last edited by Boghog 41 days ago. Reviewer: Inform author.

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Comment: Please include more citations to demonstrate this topic's notability. As of right now, the first source is about ohlofentanil, so there's effectively only one source about this topic. Secondary sources are highly encouraged (per WP:SECONDARY), but I wouldn't go too hard on requesting that the sources be secondary for niche topics like this. Happy editing! Pygos (talk) 06:16, 8 December 2024 (UTC)

Comment: The content on this page could easily be incorporated into Ohmecarfentanil until there is enough information to split that page into multiple articles. – Jonesey95 (talk) 05:32, 9 December 2024 (UTC)

4''-Fluoro-Ohlofentanil is a synthetic opioid that is potentially more potent than Ohlofentanil. Ohlofentanil has been reported to exhibit a potency approximately 30,000 times that of morphine in the rhesus monkey single-dose suppression test.^[1] Similarly, the related compound (+)-cis-(3R,4S,2'S)-4''-Fluoro-Ohmefentanyl has demonstrated a potency approximately 17,958 times that of morphine in subcutaneous administration tests conducted on mice.^[2] Among the stereoisomers of 4''-Fluoro-Ohlofentanil, (+)-cis-(3R,4S,2'S)-4''-Fluoro-Ohlofentanil is hypothesized to be the most potent, based on structural considerations and comparative potency data from related compounds.

References

^ Carroll FI, Lewin AH, Mascarella SW, Seltzman HH, Reddy PA (April 2021). "Designer drugs: a medicinal chemistry perspective (II)". Annals of the New York Academy of Sciences. 1489 (1): 48–77. Bibcode:2021NYASA1489...48C. doi:10.1111/nyas.14349. PMID 32396701.
^ Brine GA, Carroll FI, Richardson-Leibert TM, Xu H, Rothman RB (1997). "Ohmefentanyl and Its Stereoisomers: Chemistry and Pharmacology". Current Medicinal Chemistry. 4 (4): 247–270. doi:10.2174/0929867304666220313115017.

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[1] Carroll FI, Lewin AH, Mascarella SW, Seltzman HH, Reddy PA (April 2021). "Designer drugs: a medicinal chemistry perspective (II)". Annals of the New York Academy of Sciences. 1489 (1): 48–77. Bibcode:2021NYASA1489...48C. doi:10.1111/nyas.14349. PMID 32396701.

[2] Brine GA, Carroll FI, Richardson-Leibert TM, Xu H, Rothman RB (1997). "Ohmefentanyl and Its Stereoisomers: Chemistry and Pharmacology". Current Medicinal Chemistry. 4 (4): 247–270. doi:10.2174/0929867304666220313115017.

[1]

[2]

See also

References