Deoxyribonuclease 2 beta

DNASE2B
Identifiers
Aliases	DNASE2B, DLAD, deoxyribonuclease II beta, deoxyribonuclease 2 beta
External IDs	OMIM: 608057; MGI: 1913283; HomoloGene: 1052; GeneCards: DNASE2B; OMA:DNASE2B - orthologs
Gene location (Human) Chr. Chromosome 1 (human) Band 1p31.1-p22.3 Start 84,398,484 bp End 84,415,018 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3|3 H2 Start 146,286,740 bp End 146,321,351 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in parotid gland testicle minor salivary glands gastrocnemius muscle right lung mucosa of transverse colon upper lobe of left lung muscle of thigh prostate nucleus accumbens Top expressed in seminal vesicula epithelium of lens left lobe of liver glossopharyngeal ganglion basal plate greater petrosal nerve sternocleidomastoid muscle temporal muscle spinal ganglia iris More reference expression data BioGPS n/a
Gene ontology Molecular function deoxyribonuclease II activity nuclease activity endonuclease activity endodeoxyribonuclease activity hydrolase activity Cellular component cytoplasm extracellular region lysosome intracellular anatomical structure Biological process DNA metabolic process apoptotic DNA fragmentation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 58511 56629 Ensembl ENSG00000137976 ENSMUSG00000028185 UniProt Q8WZ79 Q66K39 Q9QY48 RefSeq (mRNA) NM_021233 NM_058248 NM_019957 RefSeq (protein) NP_067056 NP_490649 NP_067056.2 NP_064341 Location (UCSC) Chr 1: 84.4 – 84.42 Mb Chr 3: 146.29 – 146.32 Mb PubMed search
Wikidata
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Deoxyribonuclease 2 beta is a protein that in humans is encoded by the DNASE2B gene.

Function

The protein encoded by this gene shares considerable sequence similarity to, and is structurally related to DNase II. The latter is a well characterized endonuclease that catalyzes DNA hydrolysis in the absence of divalent cations at acidic pH. Unlike DNase II which is ubiquitously expressed, expression of this gene product is restricted to the salivary gland and lungs. The gene has been localized to chromosome 1p22.3 adjacent (and in opposite orientation) to the uricase pseudogene. Two transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008].

Further reading

• Shiokawa D, Tanuma SI (2001). "Isolation and characterization of the DLAD/Dlad genes, which lie head-to-head with the genes for urate oxidase". Biochem. Biophys. Res. Commun. 288 (5): 1119–28. doi:10.1006/bbrc.2001.5894. PMID 11700027.
• Edenberg HJ, Koller DL, Xuei X, Wetherill L, McClintick JN, Almasy L, Bierut LJ, Bucholz KK, Goate A, Aliev F, Dick D, Hesselbrock V, Hinrichs A, Kramer J, Kuperman S, Nurnberger JI, Rice JP, Schuckit MA, Taylor R, Todd Webb B, Tischfield JA, Porjesz B, Foroud T (2010). "Genome-wide association study of alcohol dependence implicates a region on chromosome 11". Alcohol. Clin. Exp. Res. 34 (5): 840–52. doi:10.1111/j.1530-0277.2010.01156.x. PMC 2884073. PMID 20201924.
• Flachsbart F, Franke A, Kleindorp R, Caliebe A, Blanché H, Schreiber S, Nebel A (2010). "Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study". Mutat. Res. 694 (1–2): 13–9. doi:10.1016/j.mrfmmm.2010.08.006. PMID 20800603.
• Fischer H, Scherz J, Szabo S, Mildner M, Benarafa C, Torriglia A, Tschachler E, Eckhart L (2011). "DNase 2 is the main DNA-degrading enzyme of the stratum corneum". PLOS ONE. 6 (3): e17581. Bibcode:2011PLoSO...617581F. doi:10.1371/journal.pone.0017581. PMC 3046983. PMID 21390259.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.