Deleted in lung and esophageal cancer 1

DLEC1
Identifiers
Aliases	DLEC1, CFAP81, DLC1, F56, DLC-1, deleted in lung and esophageal cancer 1, cilia and flagella associated protein, DLEC1 cilia and flagella associated protein, FAP81
External IDs	OMIM: 604050; MGI: 2443671; HomoloGene: 84733; GeneCards: DLEC1; OMA:DLEC1 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	38,124,025 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	118,977,314 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; epithelium of bronchus; ; bronchial epithelial cell; ; olfactory zone of nasal mucosa; ; mucosa of paranasal sinus; ; nasal epithelium; ; left testis; ; right testis; ; caput epididymis; ; epithelium of nasopharynx;
	Top expressed in
	spermatid; ; renal cortex; ; spermatocyte; ; testicle; ; proximal tubule; ; human kidney; ; right kidney; ; ovary; ; hypothalamus; ; zygote;
	More reference expression data
	n/a
Gene ontology
Molecular function	molecular function;
Cellular component	cytoplasm; cytosol;
Biological process	negative regulation of cell population proliferation;
	Sources:Amigo / QuickGO
Orthologs
	9940
	320256
	ENSG00000008226
	ENSMUSG00000038060
	Q9Y238; Q32W76
	Q8BLA1
	NM_007335; NM_007336; NM_007337; NM_007338; NM_001321153
	NM_177117; NM_001368820; NM_001368821
	NP_001308082; NP_031361; NP_031363
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Deleted in lung and esophageal cancer 1 is a protein that in humans is encoded by the DLEC1 gene. ^[5]

Function

The cytogenetic location of this gene is 3p21.3, and it is located in a region that is commonly deleted in a variety of malignancies. Down-regulation of this gene has been observed in several human cancers including lung, esophageal, renal tumors, and head and neck squamous cell carcinoma. In some cases, reduced expression of this gene in tumor cells is a result of aberrant promoter methylation. Several alternatively spliced transcripts have been observed that contain disrupted coding regions and likely encode nonfunctional proteins.[provided by RefSeq, Mar 2016].

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000008226 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038060 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Deleted in lung and esophageal cancer 1". Retrieved 2018-04-05.

Kwong J, Lee JY, Wong KK, Zhou X, Wong DT, Lo KW, Welch WR, Berkowitz RS, Mok SC (April 2006). "Candidate tumor-suppressor gene DLEC1 is frequently downregulated by promoter hypermethylation and histone hypoacetylation in human epithelial ovarian cancer". Neoplasia. 8 (4): 268–78. doi:10.1593/neo.05502. PMC 1600675. PMID 16756719.
Kwong J, Chow LS, Wong AY, Hung WK, Chung GT, To KF, Chan FL, Daigo Y, Nakamura Y, Huang DP, Lo KW (February 2007). "Epigenetic inactivation of the deleted in lung and esophageal cancer 1 gene in nasopharyngeal carcinoma". Genes Chromosomes Cancer. 46 (2): 171–80. doi:10.1002/gcc.20398. PMID 17099870. S2CID 45238991.
Qiu GH, Salto-Tellez M, Ross JA, Yeo W, Cui Y, Wheelhouse N, Chen GG, Harrison D, Lai P, Tao Q, Hooi SC (March 2008). "The tumor suppressor gene DLEC1 is frequently silenced by DNA methylation in hepatocellular carcinoma and induces G1 arrest in cell cycle". J. Hepatol. 48 (3): 433–41. doi:10.1016/j.jhep.2007.11.015. PMID 18191269.
Seng TJ, Currey N, Cooper WA, Lee CS, Chan C, Horvath L, Sutherland RL, Kennedy C, McCaughan B, Kohonen-Corish MR (July 2008). "DLEC1 and MLH1 promoter methylation are associated with poor prognosis in non-small cell lung carcinoma". Br. J. Cancer. 99 (2): 375–82. doi:10.1038/sj.bjc.6604452. PMC 2480971. PMID 18594535.
Ying J, Poon FF, Yu J, Geng H, Wong AH, Qiu GH, Goh HK, Rha SY, Tian L, Chan AT, Sung JJ, Tao Q (February 2009). "DLEC1 is a functional 3p22.3 tumour suppressor silenced by promoter CpG methylation in colon and gastric cancers". Br. J. Cancer. 100 (4): 663–9. doi:10.1038/sj.bjc.6604888. PMC 2653732. PMID 19156137.
Canova C, Hashibe M, Simonato L, Nelis M, Metspalu A, Lagiou P, Trichopoulos D, Ahrens W, Pigeot I, Merletti F, Richiardi L, Talamini R, Barzan L, Macfarlane GJ, Macfarlane TV, Holcátová I, Bencko V, Benhamou S, Bouchardy C, Kjaerheim K, Lowry R, Agudo A, Castellsagué X, Conway DI, McKinney PA, Znaor A, McCartan BE, Healy CM, Marron M, Brennan P (April 2009). "Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project" (PDF). Cancer Res. 69 (7): 2956–65. doi:10.1158/0008-5472.CAN-08-2604. hdl:2318/104855. PMID 19339270.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Al Sarakbi W, Reefy S, Jiang WG, Roberts T, Newbold RF, Mokbel K (April 2010). "Evidence of a tumour suppressor function for DLEC1 in human breast cancer". Anticancer Res. 30 (4): 1079–82. PMID 20530412.
Zhang Y, Miao Y, Yi J, Wang R, Chen L (July 2010). "Frequent epigenetic inactivation of deleted in lung and esophageal cancer 1 gene by promoter methylation in non-small-cell lung cancer". Clin Lung Cancer. 11 (4): 264–70. doi:10.3816/CLC.2010.n.034. PMID 20630829.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000008226 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038060 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Deleted in lung and esophageal cancer 1". Retrieved 2018-04-05.

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[5]

Function

References

Further reading