DEFB129

DEFB129
Identifiers
Aliases	DEFB129, C20orf87, DEFB-29, DEFB29, bA530N10.3, hBD-29, defensin beta 129
External IDs	MGI: 3644405; HomoloGene: 83411; GeneCards: DEFB129; OMA:DEFB129 - orthologs
Gene location (Human)
Chr.	Chromosome 20 (human)
End	229,886 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	152,306,540 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; tail of epididymis; ; sperm; ; seminal vesicula; ; caput epididymis; ; sural nerve; ; apex of heart; ; integument; ; abdominal segment of trunk; ; abdomen;
	Top expressed in
	zygote; ; ovary; ; primary oocyte; ; hypothalamus; ; secondary oocyte; ; blastocyst; ; testicle; ; lung; ; white adipose tissue; ; genital tubercle;
	More reference expression data
	More reference expression data
Orthologs
	140881
	629114
	ENSG00000125903
	ENSMUSG00000074681
	Q9H1M3
	Q30KP0
	NM_080831
	NM_001037933
	NP_543021
	NP_001033022
	Wikidata
View/Edit Human	View/Edit Mouse

Beta-defensin 129 is a protein that in humans is encoded by the DEFB129 gene.^[5]^[6]

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000125903 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000074681 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved β-defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. Bibcode:2002PNAS...99.2129S. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.
^ ^a ^b "Entrez Gene: DEFB129 defensin, beta 129".

Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
Rodríguez-Jiménez FJ, Krause A, Schulz S, et al. (2003). "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis". Genomics. 81 (2): 175–83. doi:10.1016/S0888-7543(02)00034-4. PMID 12620395.
Kao CY, Chen Y, Zhao YH, Wu R (2003). "ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes". Am. J. Respir. Cell Mol. Biol. 29 (1): 71–80. CiteSeerX 10.1.1.108.7808. doi:10.1165/rcmb.2002-0205OC. PMID 12600824.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000125903 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000074681 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11854508-5] Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved β-defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A. 99 (4): 2129–33. Bibcode:2002PNAS...99.2129S. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508.

[entrez-6] "Entrez Gene: DEFB129 defensin, beta 129".

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References

Further reading