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Contralateral brain

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Contralateral brain

The contralateral organization of the forebrain (Latin: contra‚ against; latus‚ side; lateral‚ sided) is the property that the hemispheres of the cerebrum and the thalamus represent mainly the contralateral side of the body. Consequently, the left side of the forebrain mostly represents the right side of the body, and the right side of the brain primarily represents the left side of the body. The contralateral organization involves both executive and sensory functions (e.g., a left-sided brain lesion may cause a right-sided hemiplegia). The contralateral organization is only present in vertebrates.

A number of theories have been put forward to explain this phenomenon, but none are generally accepted.[1] These include, among others, Cajal's visual map theory, different topological approaches, the somatic twist theory and the axial twist theory.[1]

Anatomy

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Some afferent decussations.
Pyramidal decussations.

Anatomically, the contralateral organization is manifested by major decussations (based on the Latin notation for ten, 'deca,' as an uppercase 'X') and chiasmas (after the Greek uppercase letter 'Χ,' chi). A decussation denotes a crossing of bundles of axonal fibres inside the central nervous system. Due to decussations the efferent connections of the cerebrum to the basal ganglia, the cerebellum and the spine are crossed; and the afferent connections from the spine, the cerebellum and the pons to the thalamus are crossed.[2]: 69, Fig. 6.3, 6.13, 6.20  Thus, motor, somatosensory, auditory, and visual primary regions in the forebrain predominantly represent the contralateral side of the body.

Two of the cranial nerves show chiasmas: (1) the chiasma of the optic tract (i.e., cranial nerve II), which originates from the eyes and inserts on the optic tectum of the midbrain; and (2) the trochlear nerve (i.e., cranial nerve IV), which originates in the ventral midbrain and innervates one of the six muscles that rotate the eye (i.e., the superior oblique muscle). The oculomotor nerve (cranial nerve III) crosses the midline before leaving the central nervous system (i.e. it decussates rather than chiasmates).[2]: Figs. 6.11, 17.8 [3][4]

The contralateral organization is incomplete

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Although the forebrain of all vertebrates shows a contralateral organization, this contralaterality is by no means complete. Some of these exceptions are worth mentioning:

  • Olfaction (i.e., smelling sense) is a noteworthy exception. Each olfactory lobe connects to the ipsilateral (same-side) centers of the frontal cerebrum.[2]: Figs. 11.3, 11.7 
  • In chondrichthyans (e.g., sharks and skates), the thalamus does not retrieve a branch from the optic tract but only from the contralateral optic tectum, so that the optic path decussates twice, and the forebrain represents the ipsilateral (same-side) eye.[5][6]
  • In large brains (e.g., humans, elephants and whales), some functions tend to be strongly lateralized. For example, the language regions (i.e., Broca's and Wernicke's area) are situated in the left hemisphere of most humans.[7]
  • Most afferent and efferent connections of the forebrain have bilateral components, especially outside the primary sensory and motor regions.[8] As a result, a hemiplegia that is acquired at very young age can sometimes be completely compensated over time.[9]

Theories

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Main article: Axial Twist theory

According to current understanding, the contralateral organization is due to an axial twist (explained below). A number of other explanations have been published, the most popular of which is the visual map theory (explained below). A short review of existing hypotheses is given by reference.[10] A popular-science video explains these theories in brief.[11]

The Visual Map Theory and the Axial Twist Theory have been formulated in detail and can be regarded as scientific theories, and are explained in detail below.

Other hypotheses tend to explain specific aspects of the phenomenon. One proposes that crossing generally provides better geometrical mapping.[12] According to another view, the crossing is a coincidence that has been conserved by parcellation.[8] A third hypothesis proposes that the crossing results directly from optical inversion on the retina of the eye.[13]

An old notion, first worked out by Jacques Loeb, is that the contralateral organisation might have an advantage for motor control,[14][15] but simulations by Valentino Braitenberg have shown that both ipsi- and contralateral connections are of major importance for control.[16]

Further studies have asked if there is a topological[17] or functional advantage of the decussations.[18][19][20]

Visual map theory

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schematic drawing of the central nervous system, showing schematically how arrow halves are projected on the eyes' retina, crossed by the optic chiasm and mapped correctly to the visual cortex
Cajal's schema of the visual map theory. O=Optic chiasm; C=Visual (and motor) cortex; M, S=Decussating pathways; R, G: Sensory nerves, motor ganglia.
Transformations of the visual field toward the visual map on the primary visual cortex. U=up; D=down; L=left; R=right; F=fovea

The visual map theory was published by the famous neuroscientist and pioneer Santiago Ramón y Cajal (1898). According to this theory, the function of the optic chiasm is to repair the retinal field image on the visual cortex. The pupil in the vertebrates’ eyes inverts the image on the retina, so that the visual periphery projects to the medial side of the retina. By the chiasmatic crossing, the visual periphery is again on the outside, if one assumes that the retinal map is faithfully maintained throughout the optic tract.[21][22][23]

The theory has a number of weaknesses. For example, the visual tracts spiral their way from the thalamic LGN to the visual cortex. (See figure; this path is known as the optic radiation.) As a result, the retinal map shows the visual periphery on the medial side. However, the central objective of the theory was to obtain a precise, faithful visual map with the medial field projecting to the medial sides of the visual cortex.[10]

Axial twist

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Main article: Axial twist theory

Two twist hypotheses have been proposed independently: the axial twist by de Marc Lussanet and Jan Osse[10] and the somatic twist by Marcel Kinsbourne.[24] Both of them propose that the rostral part of the head, including the forebrain, is in fact effectively completely turned around. As a consequence, the left and right in the brain are reversed, but also anterior (frontal) and posterior (back / occipital).[25] Whereas the somatic twist hypothesis focuses purely on the morphological phenomenon of the inversions of the forebrain, the axial twist theory also addresses the development and the evolution.[25]

The scientific method has been used on the axial twist theory to generate empirically testable predictions, all of which were confirmed, albeit in a work by the first author of the theory.[26]

Axial twist theory

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caption
Schema of the developmental twist, according to the axial twist hypothesis. A, B: The early embryo turns onto its left side; B, C: Symmetry is retained by a further left turn in the anterior head region and a compensating right turn in the rest of the body. D, E: Growth of the optic tract leading to the optic chiasma. Colors refer to early embryo: Red=right side, blue=left side, black=dorsal, white=ventral.

The axial twist theory was designed to explain how the pattern of contralateral organization,[10] decussations and chiasmas develops, and why this pattern is so evolutionarily stable,[25] having no known exceptions throughout the 500 million years of vertebrate evolution. According to the theory, the contralateral organization develops as follows: The early embryo is turned onto its left side, such that its left is turned to the yolk and its right is turned away from the yolk. This asymmetric orientation is compensated by asymmetric growth, to regain superficial bilateral symmetry. The anterior head region turns to the left, as shown in the schema. The forebrain is not a superficial structure, but it is so intimately associated with superficial body structures that it turns along with the anterior head. These structures will later form the eyes, nostrils and mouth.[10]

The body behind the head compensates the asymmetric body orientation in the opposite direction, by turning to the right. (See schema.) Due to these oppositely directed compensations of the anterior head and the rest of the body, the animal becomes twisted.[10]

The optic tract grows from the retina to the optic tectum. Because dorsal and ventral are inverted in the anterior head region, the tracts grow at first toward the ventral side, to meet in the midline to form a chiasma. Since the optic tectum lies on the dorsal midbrain, each tract then continues dorsally to the contralateral optic tectum.[10]

The heart and bowels are internal organs with no strong integration in external body structures, so there is no evolutionary pressure to make them turn in a similar way. Rather, these organs retain their original asymmetric orientation in the body.[10]

The axial twist hypothesis predicts that small asymmetries of the face and brain—as well as those found in the opposite direction in the trunk—remain into adulthood.[26]

Comparing inversion, somatic twist and axial twist

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The idea of a somatic twist was inspired by the dorsoventral inversion hypothesis;[27][28] and was proposed by Marcel Kinsbourne.[24]

According to the dorsoventral inversion hypothesis, an ancestral deuterostome turned on its back. As a result, vertebrates have a dorsal nervous system, whereas protostomes have a ventral one.[24] According to the somatic twist hypothesis, not the entire animal turned on its back but just the somatic part—i.e., everything behind the eyes, mouth and nostrils, including the forebrain.[10][25]

The somatic twist hypothesis was proposed as an improvement to the inversion hypothesis, and thus has a much wider explanatory power than its predecessor, but is also more complicated. It not only explains the inversion of the body but additionally the contralateral forebrain. It does not explain, however, how the twist might develop in the vertebrate embryo, nor does it address the possible evolution.

The axial twist theory was proposed independently. In addition to providing rationale for the inverted body and the contralateral forebrain, it explains why the heart and bowels are asymmetric. It is the only one of the three theories that is supported by evidence from embryological growth.[26]

Evolution

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A remarkable property of the contralateral organization is that it is present in every vertebrate. Even the most distant clades—agnathans—possess an optic chiasma,[2] and even the skull impressions of early vertebrates from the Ordovician show the presence of an optic chiasma:[29] this idea was worked out by Kinsbourne.[24] There is molecular evidence for the inversion hypothesis in almost all groups of deuterostomes.[30][31] It is not known, however, what exactly was the selective pressure that caused the inversion. Twisting and asymmetric development are well known from other deuterostomes—such as Hemichordata, Echinodermata, Cephalochordata and Tunicata. Turning toward the side or upside-down also occurs frequently in these clades (e.g. sea stars which turn their mouth downwards after the larva has briefly settled with the mouth turned up, or the adult lancelet which buries obliquely with its mouth turned up, or many fish which tend to turn around when feeding from the water surface).

Developmental malformations

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In holoprosencephaly, the hemispheres of the cerebrum or part of it are not aligned on the left and right side but only on the frontal and occipital sides of the skull, and the head usually remains very small. According to the axial twist hypothesis, this represents an extreme case of Yakovlevian torque,[32] and may occur when the cerebrum does not turn during early embryology.

Cephalopagus or janiceps twins are conjoined twins who are born with two faces, one on either side of the head. These twins have two brains and two spinal cords, but these are located on the left and the right side of the body.[33] According to the axial twist hypothesis, the two nervous systems could not turn due to the complex configuration of the body and therefore remained on either side.[10]

See also

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References

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  1. ^ a b Mora, Carla; Velásquez, Carlos; Martino, Juan (2019-09-01). "The neural pathway midline crossing theory: a historical analysis of Santiago Rámon y Cajal's contribution on cerebral localization and on contralateral forebrain organization". Neurosurgical Focus. 47 (3): E10. doi:10.3171/2019.6.FOCUS19341. ISSN 1092-0684. PMID 31473669.
  2. ^ a b c d Nieuwenhuys, R.; Donkelaar, H.J.; Nicholson, C.; Smeets, W.J.A.J.; Wicht, H. (1998). The central nervous system of vertebrates. New York: Springer. ISBN 9783642621277.
  3. ^ Muñoz, M.; González, A. (1995). "The trochlear nucleus of the frog Rana ridibunda: Localization, morphology and ultrastructure of identified motoneurons". Brain Res. Bull. 36 (5): 433–441. doi:10.1016/0361-9230(94)00233-Q. PMID 7536105.
  4. ^ Burgess, Robert W.; Jucius, Thomas J.; Ackerman, Susan L. (206). "Motor axon guidance of the mammalian Trochlear and Phrenic nerves: Dependence on the Netrin receptor Unc5c and modifier loci". J. Neurosci. 26 (21): 5756–5766. doi:10.1523/JNEUROSCI.0736-06.2006. PMC 6675264. PMID 16723533.
  5. ^ Luiten, P.G.M. (1981). "Two visual pathways to the telencephalon in the nurse shark (Ginglymostoma cirratum). I. retinal projections". J. Comp. Neurol. 96 (4): 531–538. doi:10.1002/cne.901960402. PMID 7204669. S2CID 36572723.
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  7. ^ Flinker, Adeen; Korzeniewska, Anna; Shestyuk, Avgusta Y.; Franaszczuk, Piotr J.; Dronkers, Nina F.; Knight, Robert T.; Crone, Nathan E. (2015). "Redefining the role of Broca's area in speech". Proc. Natl. Acad. Sci. USA. 112 (9): 2871–2875. doi:10.1073/pnas.1414491112. PMC 4352780. PMID 25730850.
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  16. ^ Braitenberg, Valentino (1984). Vehicles-experiments in synthetic psychology. Cambridge, MA: MIT Press.
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  24. ^ a b c d Kinsbourne, M. (2013). "Somatic twist: a model for the evolution of decussation". Neuropsychology. 27 (5): 511–515. doi:10.1037/a0033662. PMID 24040928. S2CID 11646580.
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  26. ^ a b c de Lussanet, M.H.E. (2019). "Opposite asymmetries of face and trunk and of kissing and hugging, as predicted by the axial twist hypothesis". PeerJ. 7: e7096. doi:10.7717/peerj.7096. PMC 6557252. PMID 31211022.
  27. ^ Dixon, A. Francis (1907). "Why are the great motor and sensory tracts of the central nervous system crossed?". The Dublin Journal of Medical Science. 124 (1): 1–4. doi:10.1007/BF02972358. S2CID 76086581.
  28. ^ Kinsbourne, M. (1978). Asymmetrical function of the brain. Cambridge: Cambridge University Press. p. 5.
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  30. ^ Nübler-Jung, Katharina; Arendt, Detlev (1996). "Enteropneusts and chordate evolution". Current Biology. 6 (4): 352–353. Bibcode:1996CBio....6..352N. doi:10.1016/S0960-9822(02)00491-8. PMID 8723329. S2CID 8964529.
  31. ^ Arendt, Detlev; Nübler-Jung, Katharina (1994). "Inversion of dorsoventral axis?". Nature. 371 (6492): 26. Bibcode:1994Natur.371...26A. doi:10.1038/371026a0. PMID 8072524. S2CID 33780610.
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