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Pancreatic endopeptidase E

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Pancreatic endopeptidase E
Identifiers
EC no.3.4.21.70
CAS no.68073-27-8
Databases
IntEnzIntEnz view
BRENDABRENDA entry
ExPASyNiceZyme view
KEGGKEGG entry
MetaCycmetabolic pathway
PRIAMprofile
PDB structuresRCSB PDB PDBe PDBsum
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PMCarticles
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NCBIproteins

Pancreatic endopeptidase E (EC 3.4.21.70, cholesterol-binding proteinase, proteinase E, cholesterol-binding serine proteinase, pancreatic protease E, pancreatic proteinase E, cholesterol-binding pancreatic proteinase, CBPP, pancreas E proteinase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Preferential cleavage: Ala-. Does not hydrolyse elastin

This enzyme is peptidase of family S1 (trypsin family) from pancreatic juice.

References

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  1. ^ Mallory PA, Travis J (February 1975). "Human pancreatic enzymes: purification and characterization of a nonelastolytic enzyme, protease E. resembling elastase". Biochemistry. 14 (4): 722–30. doi:10.1021/bi00675a012. PMID 234742.
  2. ^ Shen WF, Fletcher TS, Largman C (June 1987). "Primary structure of human pancreatic protease E determined by sequence analysis of the cloned mRNA". Biochemistry. 26 (12): 3447–52. doi:10.1021/bi00386a030. PMID 3477287.
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