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Cheon Jinwoo

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Cheon Jinwoo
Born1962
NationalitySouth Korean
Alma materYonsei University, University of Illinois at Urbana-Champaign
Known forNanoscience and nanomedicine
Awards2010 Inchon Award (Inchon Memorial Foundation)

2012 Korea’s 100 Most Influential Person for Next 10 Years (DongA Daily News)
2012 POSCO TJ Park Prize (POSCO TJ Park Foundation)

2015 Ho-Am Prize in Science (Ho-Am Foundation)
Scientific career
FieldsInorganic chemistry, materials chemistry, nanoscience, nanocrystals
InstitutionsYonsei University, Institute for Basic Science, Center for Nanomedicine
Theses
Doctoral advisorsGregory S. Girolami
Korean name
Hangul
천진우
Revised RomanizationCheon Jin-u
McCune–ReischauerCh'ŏn Jinu
Websitecheongroup.yonsei.ac.kribs.yonsei.ac.kr

Cheon Jinwoo is the H.G. Underwood Professor at Yonsei University[1] and the Founding Director of the Center for Nanomedicine, Institute for Basic Science (IBS). As a leading chemist in inorganic materials chemistry[2] and nanomedicine[3] Cheon and his research group mainly focus on developing chemical principles for synthesizing complex inorganic materials and nanoprobes/actuators used in imaging and controlling of cellular functions within the deep tissue in living systems.

Throughout his career, he has received numerous prestigious awards, including Inchon Prize (2010), ChungAm Prize (2012), Ho-Am Prize (2015), Clarivate Analytics Highly Cited Researcher in the field of chemistry (2014, 2015, 2016) and cross-field (2018).[4] He is a fellow of the American Chemical Society, Royal Society of Chemistry, and Korean Academy of Science and Technology. In addition to his research, he serves as a senior editor of Accounts of Chemical Research[5] and an editorial advisory board member of several leading journals, including Journal of Materials Chemistry, Nano Letters,[6] Materials Horizons,[7] and C&EN.

Education

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Cheon began his academic journey at Yonsei University in 1981, where he majored in chemistry. He earned both his Bachelor of Science and Master of Science in 1985 and 1987 at Yonsei University, respectively. In 1993, under the guidance of Professor Gregory S. Girolami, he received his Ph.D. in chemistry from the University of Illinois at Urbana-Champaign.

Career

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Following his doctoral studies, he continued his research as a postdoctoral fellow at the University of California Berkeley. For the next three years, he was a staff research associate at UC, Los Angeles (UCLA) before returning to South Korea to work as an assistant and then associate professor at KAIST. His research at KAIST focused on geometrical shape control of nanoparticles[8] and magnetic particles.[9][10] This also marked his first publication on nanocrystals[11] which is a reoccurring interest in his research career and a source of multiple highly cited articles.[12][13][14][15]

He started working at Yonsei University as a full professor in 2002 and later became the Horace G. Underwood Professor in 2008.[16] From 2010 to 2016, Cheon was the director of the National Creative Research Initiative Center for Evolutionary Nanoparticles. In 2015, he became the founding director of IBS Center for Nanomedicine at the Yonsei University (IBS CNM at Yonsei) in Seoul and has been serving as a director since then.

His research at Yonsei on nanoscale phenomena has led to nanomaterial applications in biology, including highly sensitive MRI contrast agents[17][18][19] and nanoscale toolkits for cells. In 2004, he demonstrated the principle of size-dependent MRI contrast effects using nanoparticles which enabled the development of magnetism-engineered iron oxide (MEIO) as an ultra-sensitive nanoparticle MRI contrast agent which might help detect early-stage cancer.[15][20] Cheon also has developed magnetic nanomachines which have various mechanical components in hundreds nanometer scale, allowing remote and precise controlling of nanostructures using magnetic fields.[21] These nanomachines are promising for targeted drug delivery and minimally invasive surgery, enhancing functionality by such mechanical components. From 2021, his work has notably advanced the field of magnetogenetics for wireless control of deep tissue in vivo systems, especially brain activities.[22][23] Magnetogenetics uses mechanical torque or force of magnetic nanoparticles to manipulate neuronal activity with mechanosensitive ion channels (e.g. Piezo1), offering a non-invasive method in meter scale long-distance to control brain function. This innovative approach allows for the precise regulation of neuronal circuits using magnetic fields, providing potential new treatments for neurological disorders and insights into brain function.

Awards and honors

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Selected recent publications

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  • Lin, Mouhong; Lee, Jung-uk; Kim, Youngjoo; Kim, Gooreum; Jung, Yunmin; Jo, Ala; Park, Mansoo; Lee, Sol; Lah, Jungsu David; Park, Jongseong; Noh, Kunwoo; Lee, Jae-Hyun; Kwak, Minsuk; Lungerich, Dominik; Cheon, Jinwoo (2024-05). "A magnetically powered nanomachine with a DNA clutch". Nature Nanotechnology. 19 (5): 646–651. doi:10.1038/s41565-023-01599-6. ISSN 1748-3395.
  • Kim, W.-S.; Min, S.; Kim, S.K.; Kang, S.; An, S.; Criado-Hidalgo, E.; Davis, H.; Bar-Zion, A.; Malounda, D.; Kim, Y.H.; Lee, J.-H.; Bae, S.H.; Lee, J.G.; Kwak, M.; Cho, S.-W.; Shapiro, M.G.; Cheon, J. “Magneto-acoustic protein nanostructures for non-invasive imaging of tissue mechanics in vivo” Nat. Mater., 2024, 23, 290.
  • Lee, J. U.; Shin, W.; Lim, Y.; Kim, J.; Kim, W. R.; Kim, H.; Lee, J. H.; Cheon, J. "Non-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals" Nat. Mater., 2021, 20, 1029.
  • Shin, T.-H.; Kim, P. K.; Kang, S.; Cheong, J.; Kim, S.; Lim, Y.; Shin, W.; Jung, J.-Y.; Lah, J. D.; Choi, B. W.; Cheon, J. "High-resolution T1 MRI via renally clearable dextran nanoparticles with an iron oxide shell" Nat. Biomed. Eng., 2021, 5, 252.
  • Cheong, J.; Yu, H.; Lee, C. Y.; Lee, J.-u.; Choi, H.-J.; Lee, J.-H.; Lee, H.; Cheon, J. "Fast detection of SARS-CoV-2 RNA via the integration of plasmonic thermocycling and fluorescence detection in a portable device" Nat. Biomed. Eng., 2020, 4, 1159.
  • Lim, Y.; Lee, C.-H.; Jun, C.-H.; Kim, K.; Cheon, J. “Morphology-conserving non-kirkendall anion exchange of metal oxide nanocrystals” J. Am. Chem. Soc. 2020, 142, 9130
  • Choi, J.; Kim, S.; Cheon, J.  et al. "Distance-dependent magnetic resonance tuning as a versatile MRI sensing platform for biological targets" Nat. Mater. 2017, 16, 537.
  • Seo, D.; Southard, K.M.; Cheon, J.; Jun, Y-w. et al. "A Mechanogenetic toolkit for interrogating cell signaling in space and time" Cell, 2016, 165, 1507.
  • Jeong, Sohee; Yoo, Dongwon; Ahn, Minji; Miró, Pere; Heine, Thomas; Cheon, Jinwoo (2015-01-09). "Tandem intercalation strategy for single-layer nanosheets as an effective alternative to conventional exfoliation processes". Nature Communications. 6 (1). Springer Science and Business Media LLC: 5763. Bibcode:2015NatCo...6.5763J. doi:10.1038/ncomms6763. ISSN 2041-1723. PMID 25575047.
  • Lee, Jae-Hyun; Kim, Ji-wook; Levy, Michael; Kao, Albert; Noh, Seung-hyun; Bozovic, Dolores; Cheon, Jinwoo (2014-07-08). "Magnetic Nanoparticles for Ultrafast Mechanical Control of Inner Ear Hair Cells". ACS Nano. 8 (7). American Chemical Society (ACS): 6590–6598. doi:10.1021/nn5020616. ISSN 1936-0851. PMID 25004005.
  • Han, Jae Hyo; Lee, Sujeong; Yoo, Dongwon; Lee, Jae-Hyun; Jeong, Sohee; Kim, Jin-Gyu; Cheon, Jinwoo (2013-03-04). "Unveiling Chemical Reactivity and Structural Transformation of Two-Dimensional Layered Nanocrystals". Journal of the American Chemical Society. 135 (10). American Chemical Society (ACS): 3736–3739. doi:10.1021/ja309744c. ISSN 0002-7863. PMID 23458758.
  • Cho, Mi Hyeon; Lee, Eun Jung; Son, Mina; Lee, Jae-Hyun; Yoo, Dongwon; Kim, Ji-wook; Park, Seung Woo; Shin, Jeon-Soo; Cheon, Jinwoo (2012-10-07). "A magnetic switch for the control of cell death signalling in in vitro and in vivo systems". Nature Materials. 11 (12). Springer Science and Business Media LLC: 1038–1043. Bibcode:2012NatMa..11.1038C. doi:10.1038/nmat3430. ISSN 1476-1122. PMID 23042417.
  • Jeong, Sohee; Yoo, Dongwon; Jang, Jung-tak; Kim, Minkyoung; Cheon, Jinwoo (2012-10-29). "Well-Defined Colloidal 2-D Layered Transition-Metal Chalcogenide Nanocrystals via Generalized Synthetic Protocols". Journal of the American Chemical Society. 134 (44). American Chemical Society (ACS): 18233–18236. doi:10.1021/ja3089845. ISSN 0002-7863. PMID 23106819.
  • Lee, Jae-Hyun; Jang, Jung-tak; Choi, Jin-sil; Moon, Seung Ho; Noh, Seung-hyun; Kim, Ji-wook; Kim, Jin-Gyu; Kim, Il-Sun; Park, Kook In; Cheon, Jinwoo (2011-06-26). "Exchange-coupled magnetic nanoparticles for efficient heat induction". Nature Nanotechnology. 6 (7). Springer Science and Business Media LLC: 418–422. Bibcode:2011NatNa...6..418L. doi:10.1038/nnano.2011.95. ISSN 1748-3387. PMID 21706024.
  • Cheon, Jinwoo; Lee, Jae-Hyun (2008-12-16). "Synergistically Integrated Nanoparticles as Multimodal Probes for Nanobiotechnology". Accounts of Chemical Research. 41 (12). American Chemical Society (ACS): 1630–1640. doi:10.1021/ar800045c. ISSN 0001-4842. PMID 18698851.
  • Jun, Young-wook; Lee, Jae-Hyun; Cheon, Jinwoo (2008-06-27). "Chemical Design of Nanoparticle Probes for High-Performance Magnetic Resonance Imaging". Angewandte Chemie International Edition. 47 (28). Wiley: 5122–5135. doi:10.1002/anie.200701674. ISSN 1433-7851. PMID 18574805.
  • Lee, Jae-Hyun; Huh, Yong-Min; Jun, Young-wook; Seo, Jung-wook; Jang, Jung-tak; Song, Ho-Taek; Kim, Sungjun; Cho, Eun-Jin; Yoon, Ho-Geun; Suh, Jin-Suck; Cheon, Jinwoo (2006-12-24). "Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging". Nature Medicine. 13 (1). Springer Science and Business Media LLC: 95–99. doi:10.1038/nm1467. ISSN 1078-8956. PMID 17187073. S2CID 29754455.

References

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  1. ^ 한, 림원 (17 January 2018). "천진우 이학부 정회원(연세대 교수), 언더우드 특훈교수로 선정". Science and Academy Today (in Korean). Retrieved 3 July 2019.
  2. ^ a b "Angewandte News - TJ Park Science Award for Jinwoo Cheon". Angewandte Chemie International Edition. 52: 2157. 2013. doi:10.1002/anie.201210065. Retrieved 2 July 2019.
  3. ^ a b Underhill, James (29 June 2018). "International alumni awards". Illinois Alumni Association (in Korean). Retrieved 3 July 2019.
  4. ^ "IBS Places First Among Korean Institutions by Featuring 9 Scientists in List of Highly Cited Researchers". Institute for Basic Science. 4 December 2018. Retrieved 12 February 2019.
  5. ^ "Editorial Board". ACS Publications. American Chemical Society. Retrieved 3 July 2019.
  6. ^ Han, Jae Hyo; Lee, Sujeong; Cheon, Jinwoo (4 December 2012). "Synthesis and structural transformations of colloidal 2D layered metal chalcogenide nanocrystals". Chemical Society Reviews. 42 (7): 2581–2591. doi:10.1039/C2CS35386E. PMID 23212120. Retrieved 3 July 2019.
  7. ^ Keltie, Sam (24 June 2013). "Announcing new appointments to the Materials Horizons Advisory Board". Materials Horizons Blog. Royal Society of Chemistry. Retrieved 3 July 2019.
  8. ^ Hong, Young-Kyu; Kim, Hanchul; Lee, Geunseop; Kim, Wondong; Park, Jong-Il; Cheon, Jinwoo; Koo, Ja-Yong (30 January 2002). "Controlled two-dimensional distribution of nanoparticles by spin-coating method". Applied Physics Letters. 80 (844): 844–846. Bibcode:2002ApPhL..80..844H. doi:10.1063/1.1445811. Retrieved 4 July 2019.
  9. ^ Park, Jong-Il; Cheon, Jinwoo (20 June 2001). "Synthesis of "solid solution" and "core-shell" type cobalt− platinum magnetic nanoparticles via transmetalation reactions". Journal of the American Chemical Society. 24 (123): 5743–5746. doi:10.1021/ja0156340. PMID 11403607. Retrieved 4 July 2019.
  10. ^ Jun, Young-wook; Jung, Yoon-young; Cheon, Jinwoo (30 January 2002). "Architectural control of magnetic semiconductor nanocrystals". Journal of the American Chemical Society. 124 (4): 615–619. doi:10.1021/ja016887w. PMID 11804492. Retrieved 4 July 2019.
  11. ^ Jun, Young-wook; Choi, Chang-Shik; Cheon, Jinwoo (2001). "Size and shape controlled ZnTe nanocrystals with quantum confinement effect". Chem. Commun. (1): 101–102. doi:10.1039/B008376N. Retrieved 4 July 2019.
  12. ^ Jun, Young-wook; Huh, Yong-Min; Choi, Jin-sil; Lee, Jae-Hyun; Song, Ho-Taek; Kim, Sungjun; Yoon, Sarah; Kim, Kyung-Sup; Shin, Jeon-Soo; Suh, Jin-Suck; Cheon, Jinwoo (27 April 2005). "Nanoscale Size Effect of Magnetic Nanocrystals and Their Utilization for Cancer Diagnosis via Magnetic Resonance Imaging". Journal of the American Chemical Society. 127 (16): 5732–5733. doi:10.1021/ja0422155. PMID 15839639. Retrieved 4 July 2019.
  13. ^ Jun, Young-wook; Choi, Jin-sil; Cheon, Jinwoo (2006). "Shape Control of Semiconductor and Metal Oxide Nanocrystals through Nonhydrolytic Colloidal Routes". Angewandte Chemie International Edition. 45 (21): 3414–3439. doi:10.1002/anie.200503821. PMID 16642516. Retrieved 4 July 2019.
  14. ^ Huh, Yong-min; Jun, Young-wook; Song, Ho-taek; Kim, Sungjun; Choi, Jin-sil; Lee, Jae-Hyun; Yoon, Sarah; Kim, Kyung-sup; Shin, Jeon-soo; Suh, Jin-suck; Cheon, Jinwoo (16 August 2005). "In vivo magnetic resonance detection of cancer by using multifunctional magnetic nanocrystals". Journal of the American Chemical Society. 127 (35): 12387–12391. doi:10.1021/ja052337c. PMID 16131220. Retrieved 4 July 2019.
  15. ^ a b Cheon, Jinwoo; Kang, Nam-Jung; Lee, Sang-Min; Lee, Jae-Hyun; Yoon, Ji-Hyun; Oh, Sang Jun (25 February 2004). "Shape evolution of single-crystalline iron oxide nanocrystals". Journal of the American Chemical Society. 126 (7): 1950–1951. doi:10.1021/ja038722o. PMID 14971924. Retrieved 4 July 2019.
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  17. ^ Jang, Jung-tak; Nah, Hyunsoo; Lee, Jae-Hyun; Moon, Seung Ho; Kim, Min Gyu; Cheon, Jinwoo (2 February 2009). "Critical enhancements of MRI contrast and hyperthermic effects by dopant-controlled magnetic nanoparticles". Angewandte Chemie. 121 (7): 1260–1264. Bibcode:2009AngCh.121.1260J. doi:10.1002/ange.200805149. Retrieved 4 July 2019.
  18. ^ Shin, Tae-Hyun; Choi, Jin-sil; Yun, Seokhwan; Kim, Il-Sun; Song, Ho-Taek; Kim, Youngmee; Park, Kook In; Cheon, Jinwoo (2014). "T1 and T2 Dual-Mode MRI Contrast Agent for Enhancing Accuracy by Engineered Nanomaterials". ACS Nano. 8 (4): 3393–3401. doi:10.1021/nn405977t. PMID 24673493. Retrieved 4 July 2019.
  19. ^ United States Pending US20160000942A1, Jin Woo Cheon & Tae Hyun Shin, "Mri contrast agent including t1 contrast material coated on surface of nanoparticle support" 
  20. ^ Hanaoka, Kenjiro (7 February 2007). "Hot off the Press: Ultra-sensitive magnetic nanoparticles for magnetic resonance imaging". Molecular BioSystems. 3: 169–171. doi:10.1039/b701393k. Retrieved 4 July 2019.
  21. ^ Lin, Mouhong; Lee, Jung-uk; Kim, Youngjoo; Kim, Gooreum; Jung, Yunmin; Jo, Ala; Park, Mansoo; Lee, Sol; Lah, Jungsu David; Park, Jongseong; Noh, Kunwoo; Lee, Jae-Hyun; Kwak, Minsuk; Lungerich, Dominik; Cheon, Jinwoo (May 2024). "A magnetically powered nanomachine with a DNA clutch". Nature Nanotechnology. 19 (5): 646–651. doi:10.1038/s41565-023-01599-6. ISSN 1748-3395.
  22. ^ Lee, Jung-uk; Shin, Wookjin; Lim, Yongjun; Kim, Jungsil; Kim, Woon Ryoung; Kim, Heehun; Lee, Jae-Hyun; Cheon, Jinwoo (July 2021). "Non-contact long-range magnetic stimulation of mechanosensitive ion channels in freely moving animals". Nature Materials. 20 (7): 1029–1036. doi:10.1038/s41563-020-00896-y. ISSN 1476-4660.
  23. ^ Choi, Seo-Hyun; Shin, Jihye; Park, Chanhyun; Lee, Jung-uk; Lee, Jaegyeong; Ambo, Yuko; Shin, Wookjin; Yu, Ri; Kim, Ju-Young; Lah, Jungsu David; Shin, Donghun; Kim, Gooreum; Noh, Kunwoo; Koh, Wuhyun; Lee, C. Justin (September 2024). "In vivo magnetogenetics for cell-type-specific targeting and modulation of brain circuits". Nature Nanotechnology. 19 (9): 1333–1343. doi:10.1038/s41565-024-01694-2. ISSN 1748-3395.
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