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Carmantadine

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Carmantadine
Clinical data
Other namesSCH-15427; NSC-172618
Identifiers
  • 1-(1-adamantyl)azetidine-2-carboxylic acid
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.048.869 Edit this at Wikidata
Chemical and physical data
FormulaC14H21NO2
Molar mass235.327 g·mol−1
3D model (JSmol)
  • C1CN(C1C(=O)O)C23CC4CC(C2)CC(C4)C3
  • InChI=1S/C14H21NO2/c16-13(17)12-1-2-15(12)14-6-9-3-10(7-14)5-11(4-9)8-14/h9-12H,1-8H2,(H,16,17)
  • Key:VPBLOJFGPORKQA-UHFFFAOYSA-N

Carmantadine (INNTooltip International Nonproprietary Name, USANTooltip United States Adopted Name; developmental code name SCH-15427) is an antiparkinsonian agent of the adamantane group that was never marketed.[1][2][3][4] It is structurally related to amantadine and shares some of its pharmacological actions.[2] Another related drug is dopamantine.[2][3][4] Carmantadine was first described by 1972 and is said to have reached early clinical trials.[1][2][3][4]

References

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  1. ^ a b Elks J (2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer US. p. 13. ISBN 978-1-4757-2085-3. Retrieved 13 September 2024.
  2. ^ a b c d Vernier VG, du Pont E (1974). "Chapter 3. Antiparkinsonism Drugs". In Heinzelman RV (ed.). Annual Reports in Medicinal Chemistry. Vol. 9. Elsevier. pp. 19–26. doi:10.1016/s0065-7743(08)61424-4. ISBN 978-0-12-040509-1. Carmantadine (VII, Sch 151427) is structurally related to amantadine33. It shares some of its pharmacological actions, was effective in a head—turning test34 and is in early clinical trials.
  3. ^ a b c Barnett A, Goldstein J, Taber R, Fiedler E (January 1974). "Pharmacology of Dopamantine and Carmantadine, 2 Potential Antiparkinson Agents". Pharmacologist. 16 (2): 205–.
  4. ^ a b c Goldstein J, Barnett A (January 1974). "Antagonism of electrically-induced heart-turning (HT) following intracaudate administration of dopamine (DA), amantadine (AM), apomorphine (APO), dopamantine and carmantadine". Pharmacologist. 16 (2): 206.