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Carlo Catassi

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Carlo Catassi

Carlo Catassi (born April 19, 1953) is an Italian gastroenterologist, epidemiologist and researcher, known for international studies on the epidemiology of celiac disease. Currently, he is the Head of the Department of Pediatrics at the Polytechnic University of the Marches in Ancona, Italy, and a Visiting Scientist at Massachusetts General Hospital in Boston, United States. From 2013 to 2016, he served as the President of the Italian Society of Pediatric Gastroenterology, Hepatology and Nutrition (SIGENP). His research includes contributions to understanding the clinical spectrum of celiac disease and other gluten-related disorders.

Education and career

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Since 1993, he has served as a full-time Professor at the Polytechnic University of the Marches (Università Politecnica Delle Marche) in Ancona, Italy.[1] He also holds the position of Head of the Department of Pediatrics and Director of the Pediatric Residency Program. He is married to Dr. Eleonora Bove, a lawyer. They have a son and a daughter.

Key research activities

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Carlo Catassi has made contributions to the international understanding of celiac disease epidemiology. He was the main author of the first celiac disease screening project for the general population in the US.[citation needed] His study revealed that celiac disease is much more common than previously thought, affecting around 1% of the US population, while often remaining undiagnosed (so-called celiac iceberg). His original findings have been replicated by hundreds of studies performed all over the world. He investigated the prevalence of celiac disease in Europe,[2] North and South America[3][4] and Middle East countries.[5] He and his coworkers found an extremely high prevalence of celiac disease in the Saharawi population of Arab-Berber origin (around 6%) pointing out the importance of specific environmental and genetic factors to the disease pathophysiology.

He has conducted clinical trials aimed at clarifying the minimal amount of gluten needed to trigger the small intestinal damage in patients affected with celiac disease. These milestone studies formed the basis for fixing the maximum gluten contamination (20 ppm)[6] allowed in gluten-free food by regulatory International Agencies like Codex Alimentarius and US-FDA. He is co-author of “Fast Facts: Celiac Disease” with Geoffrey Holmes and Alessio Fasano[7]

In recent years, his research activities have focused on understanding environmental factors affecting the risk of developing celiac disease, particularly weaning patterns and other aspects of infant nutrition, along with understanding other forms of gluten-related disorders, particularly non-celiac gluten sensitivity (NCGS). He has guided the establishment of precise diagnostic criteria of NCGS, now known as Salerno's criteria.[8]

Catassi and his co-workers recently have provided new insights into the age of gluten introduction for infants, along with the finding that breastfeeding does not appear to influence the risk of developing celiac disease in children.[9]

Research studies

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  • Four novel mutations in the lactase gene (LCT) underlying congenital lactase deficiency (CLD).[10]
  • Celiac Disease Seems to Be on the Rise, Mainly in Elderly[11]
  • Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from an Italian central region[12]
  • Age of gluten exposure impacts development of coeliac disease[13]
  • Risk of non-Hodgkin lymphoma in celiac disease.[14]
  • Coeliac disease: a potentially treatable health problem of Saharawi refugee children.[15]

Books

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  • Manuale SIGENP di gastroenterologia ed epatologia pediatrica.[16]
  • Frontiers in celiac disease.[17]
  • The obese child.[18]
  • Celiac disease in the developing world.[19]

References

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  1. ^ "CARLO CATASSI Pagina Docente - Presentazione".
  2. ^ Catassi, C.; Fabiani, E.; Rätsch, I. M.; Coppa, G. V.; Giorgi, P. L.; Pierdomenico, R.; Alessandrini, S.; Iwanejko, G.; Domenici, R.; Mei, E.; Miano, A.; Marani, M.; Bottaro, G.; Spina, M.; Dotti, M.; Montanelli, A.; Barbato, M.; Viola, F.; Lazzari, R.; Vallini, M.; Guariso, G.; Plebani, M.; Cataldo, F.; Traverse, G.; Ughi, C.; Chiaravalloti, G.; Baldassarre, M.; Scarcella, P.; Bascietto, F.; Ceglie, L.; Valenti, A.; Paolucci, P.; Caradonna, M.; Bravi, E.; Ventura, A. (1 January 1996). "The coeliac iceberg in Italy. A multicentre antigliadin antibodies screening for coeliac disease in school-age subjects". Acta Paediatrica. 412: 29–35. doi:10.1111/j.1651-2227.1996.tb14244.x. PMID 8783752. S2CID 21109891.
  3. ^ Catassi, Carlo; Kryszak, Deborah; Louis-Jacques, Otto; Duerksen, Donald R.; Hill, Ivor; Crowe, Sheila E.; Brown, Andrew R.; Procaccini, Nicholas J.; Wonderly, Brigid A.; Hartley, Paul; Moreci, James; Bennett, Nathan; Horvath, Karoly; Burk, Margaret; Fasano, Alessio (2007). "Detection of Celiac Disease in Primary Care: A Multicenter Case-Finding Study in North America". The American Journal of Gastroenterology. 102 (7): 1454–1460. doi:10.1111/j.1572-0241.2007.01173.x. PMID 17355413. S2CID 10823009.
  4. ^ Gandolfi, L.; Pratesi, R.; Cordoba, J. C. M.; Tauil, P. L.; Gasparin, M.; Catassi, C. (1 March 2000). "Prevalence of celiac disease among blood donors in Brazil". The American Journal of Gastroenterology. 95 (3): 689–692. doi:10.1111/j.1572-0241.2000.01847.x. PMID 10710058. S2CID 345787.
  5. ^ Rostami, K.; Malekzadeh, R.; Shahbazkhani, B.; Akbari, M.R.; Catassi, C. (1 October 2004). "Coeliac disease in Middle Eastern countries: a challenge for the evolutionary history of this complex disorder?". Digestive and Liver Disease. 36 (10): 694–697. doi:10.1016/j.dld.2004.05.010. PMID 15506671.
  6. ^ Catassi, Carlo; Fabiani, Elisabetta; Iacono, Giuseppe; D'Agate, Cinzia; Francavilla, Ruggiero; Biagi, Federico; Volta, Umberto; Accomando, Salvatore; Picarelli, Antonio; Vitis, Italo De; Pianelli, Giovanna; Gesuita, Rosaria; Carle, Flavia; Mandolesi, Alessandra; Bearzi, Italo; Fasano, Alessio (1 January 2007). "A prospective, double-blind, placebo-controlled trial to establish a safe gluten threshold for patients with celiac disease". The American Journal of Clinical Nutrition. 85 (1): 160–166. doi:10.1093/ajcn/85.1.160. ISSN 0002-9165. PMID 17209192.
  7. ^ Fasano, Geoffrey Holmes, Carlo Catassi, Alessio (2009). Celiac disease (2nd ed.). Abingdon: Health Press. ISBN 978-1-905832-56-9.{{cite book}}: CS1 maint: multiple names: authors list (link)
  8. ^ Catassi, Carlo; Elli, Luca; Bonaz, Bruno; Bouma, Gerd; Carroccio, Antonio; Castillejo, Gemma; Cellier, Christophe; Cristofori, Fernanda; Magistris, Laura de; Dolinsek, Jernej; Dieterich, Walburga; Francavilla, Ruggiero; Hadjivassiliou, Marios; Holtmeier, Wolfgang; Körner, Ute; Leffler, Dan; Lundin, Knut; Mazzarella, Giuseppe; Mulder, Chris; Pellegrini, Nicoletta; Rostami, Kamran; Sanders, David; Skodje, Gry; Schuppan, Detlef; Ullrich, Reiner; Volta, Umberto; Williams, Marianne; Zevallos, Victor; Zopf, Yurdagül; Fasano, Alessio (18 June 2015). "Diagnosis of Non-Celiac Gluten Sensitivity (NCGS): The Salerno Experts' Criteria". Nutrients. 7 (6): 4966–4977. doi:10.3390/nu7064966. PMC 4488826. PMID 26096570.
  9. ^ Lionetti, Elena; Castellaneta, Stefania; Francavilla, Ruggiero; Pulvirenti, Alfredo; Tonutti, Elio; Arnarri, Sergio; Barbato, Maria; Barbera, Cristiana; Barera, Graziano; Bellantoni, Antonelia; Castellano, Emanuela; Guariso, Graziella; Limongelli, Maria Giovanna; Pellegrino, Salvatore; Polloni, Carlo; Ughi, Claudio; Zuin, Giovanna; Fasano, Alessio; Catassi, Carlo (2 October 2014). "Introduction of gluten, HLA status, and the risk of celiac disease in children". New England Journal of Medicine. 371 (14): 1295–1303. doi:10.1056/NEJMoa1400697. hdl:2318/155238. PMID 25271602.
  10. ^ "Four novel mutations in the lactase gene ( LCT ) underlying congenital lactase deficiency (CLD).(Research article)(Report)". BMC Gastroenterology. 22 January 2009. Archived from the original on 18 November 2018.
  11. ^ "Celiac Disease Seems to Be on the Rise, Mainly in Elderly: Study; Blood markers for the disease rose from 1 in every 501 individuals in 1974 to 1 in 219 by 1989.(a study by the Polytechnic University of the Marches and University of Maryland School of Medicine Center for Celiac Research)". 27 September 2010. Archived from the original on 18 November 2018.
  12. ^ "Lack of association between celiac disease and dental enamel hypoplasia in a case-control study from an Italian central region.(Case Study)(Clinical report)". Head & Face Medicine. 30 May 2007. Archived from the original on 18 November 2018.
  13. ^ "Age of gluten exposure impacts development of coeliac disease". Foods Matter. 1 November 2008. Archived from the original on 21 November 2018.
  14. ^ Catassi, Carlo. (1 January 2002). "Tveganje za ne-Hodgkinov limfom pri bolnikih s celiakijo". www.theeuropeanlibrary.org.
  15. ^ M., Rätsch, I.; C., Catassi (2001). "Coeliac disease: a potentially treatable health problem of Saharawi refugee children". Bulletin of the World Health Organization. 79 (6): 541–545. PMC 2566447. PMID 11436476.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  16. ^ Catassi, Carlo (2015). Manuale SIGENP di gastroenterologia ed epatologia pediatrica (in Italian). Il Pensiero Scientifico. p. 512. ISBN 9788849005097.
  17. ^ Fasano, Alessio; Troncone, Riccardo; Branski, D. (2008-01-01). Frontiers in Celiac Disease. Karger Medical and Scientific Publishers. ISBN 9783805585262.
  18. ^ Giorgi, Pier Luigi; Suskind, Robert M.; Catassi, Carlo (1992). The Obese Child. Karger. ISBN 9783805554848.
  19. ^ Lebwohl, Benjamin; Green, Peter H. R. (2012-11-01). Celiac Disease, an Issue of Gastrointestinal Endoscopy Clinics. Elsevier Health Sciences. ISBN 978-1455747351.
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