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Not to be confused with Lacing (drugs) § Commonly laced substances.
A drug combination chart designed for harm reduction by TripSit[1]

Polysubstance use or multisubstance use is the use of combinations of psychoactive substances with both legal and illegal substances. This page lists polysubstance combinations that are entheogenic, recreational, or off-label indicated use of pharmaceuticals. For example, the over-the-counter motion sickness combination drug dimenhydrinate (8-chlorotheophylline/diphenhydramine) is occasionally used in higher doses as a deliriant. The prescription medicine Adderall (dextroamphetamine sulfate/amphetamine sulfate/dextroamphetamine saccharate/amphetamine aspartate monohydrate) is also frequently used recreationally. However, using non-prescribed drugs, using non-prescribed dose regimen, can cause polysubstance dependence, or combined drug intoxication which may lead to deaths.

Table

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To avoid an excessively long list, the table below only lists recreational drug combinations that are not patent medicine.

Drug 1 Drug 2 Drug 3 Drug 4 Polysubstance slang,[2][3][4]
or brand name 		Intoxication name Comment
Any dissociative Any dissociative Void flip Void flipping
Any dissociative DMT Dime bar, angel flip Dimension flipping, angel flipping
Any depressant Any stimulant Speedball, powerball, over and under Powerballing, speedballing[5]
Any pharmaceutical Any pharmaceutical Polypharmacy Pharming [citation needed] Polypharmacy is most commonly defined as the use of five or more medications daily by an individual.[6] However, the definition of polypharmacy is still debated and can vary from two to 11 concurrent medications.[6]
Any drug Cannabis Amp joint[7]
Any drug Nicotine Cooler[5]
Any β-Carboline
containing plant (e.g.
Banisteriopsis caapi
or Peganum harmala) 		DMT Ayahuasca, Changa Ayahuasca is drunk. Changa is smoked or vaped.
Any antiretroviral drug Black tar heroin Whoonga, Nyaope [8] Widespread use in South Africa. Whoonga is classically reputed to be a combination of heroin with antiretroviral drugs such as ritonavir and/or efavirenz, often combined with additional drugs such as cannabis or hashish, methamphetamine and/or methaqualone
Any deliriant or diphen­hydramine MDMA Nightmare flip Nightmare flipping
2C-B or the closely related 2C-x LSD or any of the Lysergamides MDMA or any Empathogen-entactogen Ali flip[9][10] Ali flipping[9][10] This combination start as a classic Candyflip and end in a Nexus flip.

The LSD is taken first, followed by the MDMA 4 hours later and then 2C-B is taken 2 hours after the MDMA ( so 6 hours after the LSD ).

MDMA can be replaced by 6-APB, 5-APB, 6-MAPB or 5-MAPB, in this case the Empathogen is taken 2 hours after the LSD, while 2C-B may be replaced by 2C-C, 2C-D or 2C-B-FLY.

This combination's goal is to prolong the empathogenic effects of MDMA and the psychedelic effects of LSD. The idea is to have be able to experience an enhanced "Candyflipping" with a smoother comedown. The whole experience is long-lasting and can be too intense as all of these molecules synergize and potentiate each other.

2C-B MDMA Nexus flip[9][10] Nexus flipping[9][10] The MDMA is often taken first and the 2C-B after the end of the MDMA peak (h+2/h+2.½).[11]

The 2C-B is supposed to help the empathogenic effect of the MDMA last longer.

2C-B DXM Nexuswalk[12] Nexuswalk Nexus (slang for 2C-B) + Robowalk (slang for walking on DXM), similar to Nexusflipping
2C-B LSD Gnome flip
2C-E LSD MDMA Haychmaich flip[5] Haychmaich flipping
2C-P 2C-E Meskini Trip Meskini Tripping
2C-E MDMA or any Empathogen-entactogen 2C-B or the closely related 2C-x Elias flip[5] Elias flipping The Elias Flipping inspired by the Ali Flip with the use of 2C-E instead of LSD.
2C-E LSD or closely related Lysergamides MDMA or any Empathogen 2C-B or closely related 2C-x Alias Flip Alias flipping The Alias flip is a very powerful mix between an Elias flip and an Ali flip. The idea is to take substances in this order to maximize the duration of 2C-E with the LSD taken one hour after 2C-E.
Alcohol Benzodiazepine Time flip Time flipping
Alcohol Caffeine Caffeinated alcoholic drink
Alcohol Cannabis Tincture of cannabis. Herb and Al. Judgement Day Cross fading, twisting, getting twisted[13] Called Judgement Day in Ghana when cannabis is added to the drink
Alcohol Cocaine Snow-cone Snow-coning Ethanol is metabolized into cocaethylene[14]
Alcohol MDMA Tipsy flip Tipsy flipping It may be dangerous
Alcohol Nicotine Nicotini A nicotini is any alcoholic drink which includes nicotine as an ingredient. Nicotine replacement therapy products such as mouth spray may be used.
Amphetamine Barbiturates Inbetweens[15]Bam
Amphetamine Cannabis LSD Hippie heart attack [citation needed]
Amphetamine Cocaine Snow seals
Amphetamine Heroin Bombido[15]
Amphetamine Xanax Orange Dream Blossom Cloud Rush The combination is crushed together and insufflated
Belladonna Hashish Alamout black hash[5] Mixed
Caffeine Cannabis Hippie-speedball[16][17] Hippie-speedballing
Caffeine Diphen­hydramine Sleep walk Sleepwalking
Caffeine Meth­amphetamine Ya ba, biker's coffee, kamikaze
Cacao bean Magic mushroom Aztec use of entheogens. Conventional defatted cocoa solids dissolved in fat may be used instead of whole beans.
CBD THC Low to moderate doses of CBD might reduce some of the paranoia, anxiety,[18] and reduction of hippocampal volumes that the current high potency THC marijuana (in the last decades, THC content increased and CBD content decreased) can cause, if the CBD substitutes a part of the THC dose.[19][20][21] Low doses of Kanna might also help counteract the anxiety.[22][23]
Cannabis Cocoa solids Cannabis-infused brownie Cannabis edible
Cannabis Crack cocaine Crack weed (less known: Buddha, caviar, champagne, chronic, cocktail, dirty joint, fry daddy, gimmie, gremmies, juice joint, lace, oolies, p dog, primo, thirty eight, torpedo, turbo, wollie, yeola)[24] Cocoa puffs, splitting
Cannabis Crack cocaine Heroin Major Pronin, El Diablo
Cannabis Crack cocaine PCP Jim Jones
Cannabis Damiana Damiana and other herbs can be used as a tobacco alternative for rolling joints.[25]
Cannabis DXM Nicotine Candy blunt
Cannabis Heroin or opium A-bomb, Atom bomb, stuff[5]
Cannabis MDMA Stoner flip Stoner flipping
Cannabis Ketamine Stoner Kitty
Cannabis Ketamine Cocaine Simmered Getting Simmered
Cannabis Nicotine Blunt, joint, spliff, Jonko A rolled cannabis cigarette usually made with rolling paper. A blunt is a cigar hollowed out and filled with cannabis. It is rolled with the tobacco-leaf "wrapper" from an inexpensive cigar. Blunts take their name from Phillies Blunt brand cigars.
Cannabis Opium Demetra
Cannabis PCP Wet (less known: Bionic, clickums, donk, illies, leak, love leaf, lovelies, parsley, supergrass, superweed, wet, zoom) Illing Wet is cannabis dipped in PCP [26]
Cannabis PCP Nicotine Wet blunt, dust blunt, dusted blunt, Kendrick Lamar blunt Illing
Cocaine Heroin Snowball. Other names: Belushi, bombita, murder one, whiz bang Snowballing
Cocaine Heroin LSD Frisco special[5]
Cocaine Heroin Nicotine Flamethrower, primos Cigarette laced with cocaine and heroin
Cocaine Ketamine CK1, Calvin Klein, Cable, Party bag, Coquette While CK1, Calvin Klein and Cable are all names for using both substances; a Party bag is in specific reference to when the substances are mixed in a single bag prior to use.
Cocaine Ketamine MDMA Ketamollicaine
Cocaine LSD MDMA Candy-flip on a string Candy-flipping on a string High risk on health
Cocaine MDMA Sugar flip Sugar flipping
Cocaine Morphine C & M
Cocaine PCP Space, whack
Cocaine Wine Coca wine Ethanol is metabolized into cocaethylene
Cocaine Quetiapine Q-ball
Codeine Glutethimide Pancakes and syrups Combination of glutethimide and codeine cough syrup
Codeine Promethazine Lean, purple drank, oil
Crack cocaine Fentanyl Dirty fentanyl, takeover [citation needed]
Crack cocaine Heroin Chocolate rock, dragon rock, eightball, moonrock, smoking gun, tar
Crack cocaine LSD Cracid, outerlimits Cracid is a portmanteau of crack cocaine and acid [citation needed]
Crack cocaine Meth­amphetamine Fire, twisters
Crack cocaine Nicotine Coolie, crimmie, woolas A cigarette laced with crack [citation needed]
Crack cocaine Nicotine PCP Ozone PCP and crack cigarette [citation needed]
Crack cocaine PCP Missile base, P-funk, space base, spaceball, space cadet, space dust, tragic magic Missile basing, space basing
Diphen­hydramine DXM OTC flip, counterflipping OTC flipping, robowalking on a string
DMT LSD Cosmo flip, Meadow flip Cosmo flipping, meadow flipping
DMT LSD Psilocybin or psilocybin mushroom Super flip Super flipping Take LSD and shrooms then at the come up smoke DMT
DMT MAOIs Pharmahuasca
DMT Psilocybin or psilocybin mushroom Terence flip Terence flipping
DMT Nitrous oxide Dimension flip Dimension flipping Nitrous oxide can, allegedly, briefly multiply the effects of psychedelics like DMT or NB-DMT[27]
DMT Alcohol Spyder, Spyder spin Spyder spinning
DXM LSD LSDXM
DXM MDMA Robo flip Robo flipping
DXM Psilocybin or psilocybin mushroom Cherry-bomb Cherry-bombing
Fentanyl Heroin Birria, chiva loca, Facebook Facebook is mixed in a pill form [citation needed]
Fentanyl
(and/or heroin) 		Xylazine Tranq, Tranq dope "Tranq" is sometimes used to refer to xylazine by itself, but as a drug of abuse it is invariably combined with heroin or fentanyl
GHB MDMA Gamma flip Gamma flipping
GHB Meth­amphetamine Cherry meth
Hashish Crack cocaine Double zero
Hashish LSD Royal temple ball The hashish is mixed with LSD and rolled into a ball intended for oral use, because LSD cannot be smoked.
Hashish Opium Black hash, black Russian
Heroin Meth­amphetamine Goofball
Heroin Morphine New Jack swing
Heroin PCP Alien sex fiend[5]
Ketamine LSD Dolphin flip Dolphin flipping
Ketamine MDMA Kitty flip,[28] MK-ultra Kitty flipping
Ketamine Psilocybin or Psilocybin mushrooms Funky flip, chonk Funky flipping, chonking Fungus and K: one confirmed option is to ingest a low (0.75g) dose of psilocybin, wait 45 minutes, snort half a moderate dose of powdered ketamine, wait 10 minutes, snort the other half
LSD Caffeine Hoffmann[29] Flip Hoffmann flipping Dose the LSD (amount of your choice). After 30 minutes drink 250ml of coffee and keep your usual coffee drinking habit throughout the day.

(Albert Hofmann x James Hoffmann)

LSD Ketamine MDMA Holy Trident, Martin Luther King flip, Galaxy flip Holy Tridenting, Martin Luther King flipping, Galaxy Flipping
LSD MDMA Candy flip[9][10] Candy flipping[30][9][10] Generally, the MDMA is taken approximately 4 hours after the LSD ingestion.
LSD MDMA Psilocybin or psilocybin mushroom Jedi flip,[28] twilight flip Jedi flipping, twilight flipping
LSD MDMA Mushrooms Ketamine Quantum Flip Quantum Flipping Similar to Jedi flipping, but with a heavy dissociative effect induced by ketamine. The substances are taken in the order of LSD, Mushrooms, MDMA, then ketamine. Each substance should be taken at the peak of the previous substance to maximize the synergistic effects. Ketamine can be re-dosed as needed to extend the trip. The result is a highly visual and euphoric experience with periods of deep dissociation.
LSD Mescaline Stella trip
LSD Nitrous oxide Gasid Nitrous oxide can, allegedly, briefly multiply the effects of psychedelics like LSD.[27]
LSD PCP Black acid
LSD MDMA Ketamine Swalap Flip Swalaped
LSD Psilocybin or psilocybin mushroom God's flesh, Soul Bomb, Alice,[5] Wizard flip Wizard flipping
LSD Dissociatives, especially long-lasting ones such as DMXE and/or DCK. MDMA Pixie flip Pixie flipping
LSD Dissociatives, especially long-lasting ones such as DMXE and/or DCK. MDMA DMT Behind the curtain, portal flip Climbing behind the curtain, portal flipping DMT is taken last.
LSD Metocin (4-HO-MET) Neon Bomb, Diamond Bomb Neon Bombing, Diamond Bombing Metocin is taken last, usually around onset of LSD. Similar to a Soul Bomb, but because of the lower headspace and body high and higher visual effects of Metocin, the trip is more visual and stimulating.
MDMA Mescaline or psychoactive cactus Love flip, love trip Love flipping
MDMA Methadone Chocolate flip Chocolate flipping
MDMA Meth­amphetamine Trailer flip Trailer flipping
MDMA DMT Shaman flip, time flip Shaman flipping, time flipping
MDMA Nitrous oxide Nox
MDMA Opiates Poppy flip Poppy flipping
MDMA PCP Domex, elephant flip Elephant flipping
MDMA Psilocybin or psilocybin mushroom Hippie flip Hippie flipping[30]
MDMA or any Empathogen-entactogen 5-MeO-MiPT 2C-B or the closely related 2C-x Selma Flipping Selma Flip Keep the doses low, as 5-MeO-MiPT and Empathogen-entactogen can cause a Serotonin Syndrome at high doses, it's a Nexus Flip enhanced by 5-MeO-MiPT for psychedelic, entactogenic & erotic effects.
MDMA Viagra (or other PDE5 inhibitors such as Cialis or Levitra) Sextacy
MDMA Xanax Zen flip Zen flipping
MDMA Ketamine Mushrooms Obama Flip Obama Flipping
Meth­amphetamine Secobarbital, or other barbiturates Poor man's speedball
Methamphetamine Alpha-PVP Cartel meth So-called "cartel meth" is primarily composed of cutting agents such as isopropylbenzylamine and/or dimethylsulfone with a small proportion of methamphetamine plus the potent stimulant Alpha-PVP
Methaqualone Cannabis White pipe[31][32] Ingested by smoking. Popular in South Africa, elsewhere in Africa, and in India.[32]
Nicotine PCP Chipping, fry cigarette
Pentazocine Tripelannamine T's and blues
Venlafaxine Mirtazepine California rocket fuel None of the drugs are illegal and the combination is used for medical purposes.

See also

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References

[edit]
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  2. ^ "Erowid Drug Slang & Terminology Vault : A - B". erowid.org.
  3. ^ Copping, Jasper (8 November 2009). "Drug slang: what police must learn A to B".
  4. ^ "Slang Terms and Code Words: A Reference for Law Enforcement Personnel". GovInfo. Retrieved 2024-07-06.
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  6. ^ a b Masnoon, Nashwa; Shakib, Sepehr; Kalisch-Ellett, Lisa; Caughey, Gillian E. (October 2017). "What is polypharmacy? A systematic review of definitions". BMC Geriatrics. 17 (1): 230. doi:10.1186/s12877-017-0621-2. ISSN 1471-2318. PMC 5635569. PMID 29017448.
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  19. ^ Stuyt, Elizabeth (2018). "The Problem with the Current High Potency THC Marijuana from the Perspective of an Addiction Psychiatrist". Missouri Medicine. 115 (6): 482–486. ISSN 0026-6620. PMC 6312155. PMID 30643324.
  20. ^ ElSohly, Mahmoud A.; Mehmedic, Zlatko; Foster, Susan; Gon, Chandrani; Chandra, Suman; Church, James C. (2016-04-01). "Changes in Cannabis Potency over the Last Two Decades (1995-2014) - Analysis of Current Data in the United States". Biological Psychiatry. 79 (7): 613–619. doi:10.1016/j.biopsych.2016.01.004. ISSN 0006-3223. PMC 4987131. PMID 26903403.
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  24. ^ Tom Dalzell (2009), The Routledge Dictionary of Modern American Slang and Unconventional English, Routledge, ISBN 978-0-415-37182-7
  25. ^ Ewe, Koh (2021-04-19). "TikTokers Are Smoking Flowers As Weed Alternatives". www.vice.com. Retrieved 2021-12-24.
  26. ^ Holland, Julie A.; Nelson, Lewis; Ravikumar, P. R.; Elwood, William N. (22 February 2017). "Embalming Fluid-Soaked Marijuana: New High or New Guise for PCP?". Journal of Psychoactive Drugs. 30 (2): 215–219. doi:10.1080/02791072.1998.10399693. PMID 9692385. Retrieved 30 July 2021 – via Erowid.org.
  27. ^ a b "Nitrous Oxide". Drug Science. Retrieved 2024-10-03.
  28. ^ a b Nolan, James (8 February 2019). "'Kitty flipping' and the Psychonaut Obsession with Mixing Drugs". VICE.com. Retrieved 16 July 2020.
  29. ^ "James Hoffmann". YouTube. Retrieved 2024-06-07.
  30. ^ a b Zeifman, Richard J.; Kettner, Hannes; Pagni, Broc A.; Mallard, Austin; Roberts, Daniel E.; Erritzoe, David; Ross, Stephen; Carhart-Harris, Robin L. (2023-08-22). "Co-use of MDMA with psilocybin/LSD may buffer against challenging experiences and enhance positive experiences". Scientific Reports. 13 (1): 13645. doi:10.1038/s41598-023-40856-5. ISSN 2045-2322. PMC 10444769. PMID 37608057.
  31. ^ "Mandrax". DrugAware. Reality Media. 2003. Retrieved 2009-08-13.
  32. ^ a b McCarthy G, Myers B, Siegfried N (April 2005). "Treatment for methaqualone dependence in adults". The Cochrane Database of Systematic Reviews (2): CD004146. doi:10.1002/14651858.CD004146.pub2. PMID 15846700.
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